Results 131 to 140 of about 174,919 (258)

The multiscale mechanics of axon durotaxis [PDF]

arXiv
During neurodevelopment, neuronal axons navigate through the extracellular environment, guided by various cues to establish connections with distant target cells. Among other factors, axon trajectories are influenced by heterogeneities in environmental stiffness, a process known as durotaxis, the guidance by substrate stiffness gradients.
arxiv  

Acute changes in the axonal cytoskeleton after mild stretching of the rat brachial plexus [PDF]

, 2003
Kenshi Kikukawa, Kohji Fukunaga, Teiji Kato, Makio Yamaga, Eishichi Miyamoto, Katsumasa Takagi   +5 more
openalex   +1 more source

KIF9 Ameliorates Neuropathology and Cognitive Dysfunction by Promoting Macroautophagy in a Mouse Model of Alzheimer's Disease

Aging Cell, EarlyView.
KIF9 is downregulated in AD, accompanied by dysfunction in macroautophagy. Genetic upregulation of KIF9 enhances macroautophagy by promoting KLC1‐mediated anterograde transport of lysosomes, which effectively reduces Aβ deposition and alleviates cognitive impairments in AD.
Maoju Wang, Song Guo, Lilin Yi, Zhaolun Li, Xiuyu Shi, YePeng Fan, Man Luo, Yan He, Weihong Song, Yehong Du, Zhifang Dong   +10 more
wiley   +1 more source

Neurofilament light chain in the assessment of patients with multiple sclerosis

Arquivos de Neuro-Psiquiatria
Multiple sclerosis (MS) is an autoimmune, inflammatory, and degenerative disease of the central nervous system. Axonal degeneration is triggered by inflammation and is the pathological substrate of progressive disability in patients with MS.
Renan Barros DOMINGUES, Gustavo Bruniera Peres FERNANDES, Fernando Brunale Vilela de Moura LEITE, Carlos SENNE   +3 more
doaj   +1 more source

Modelling axon growing using CTRW [PDF]

arXiv, 2015
The main goal of this study is to propose a mathematical model describing paths of the axon growth cones and differences in the behavior of normal and mutant axons. We introduce a probabilistic model for axon growing, such that each family of axons is described as an ensemble of trajectories of a continuous time random walk (CTRW) model under different
arxiv  

Age‐Associated Decline in Autophagy Pathways in the Retinal Pigment Epithelium and Protective Effects of Topical Trehalose in Light‐Induced Outer Retinal Degeneration in Mice

Aging Cell, EarlyView.
Transcriptomic analyses reveal an age‐related decline in autophagy pathways in RPE/choroid. These pathways remain unchanged in early AMD but become bidirectionally dysregulated in later stages, along with increased RPE loss. Pre‐treatment with trehalose eyedrops enhances RPE autophagy flux and prevents light‐induced outer retinal degeneration in mice ...
Katherine Cox, Gongyu Shi, Neve Read, Mohamed T. Patel, Kepeng Ou, Zijia Liu, Jiahui Wu, Suci Cendanawati, Jenna Le Brun Powell, Pola Goldberg Oppenheimer, Lisa J. Hill, Lindsay B. Nicholson, Andrew D. Dick, Jian Liu   +13 more
wiley   +1 more source

Influence of a GSK3β phosphorylation site within the proximal C-terminus of Neurofilament-H on neurofilament dynamics

Biology Open, 2017
Phosphorylation of the C-terminal tail of the heavy neurofilament subunit (NF-H) impacts neurofilament (NF) axonal transport and residence within axons by fostering NF-NF associations that compete with transport.
Rishel Brenna Vohnoutka, Edward F. Boumil, Yuguan Liu, Atsuko Uchida, Harish C. Pant, Thomas B. Shea   +5 more
doaj   +1 more source

Erratum to: Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones [PDF]

, 2015
Michael Piper, Aih Cheun Lee, Francisca P. G. van Horck, Heather McNeilly, Trina Bo Lu, William A. Harris, Christine E. Holt   +6 more
openalex   +1 more source

Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Are Elevated in Bipolar Depression: Evidence for Neuroprogression and Astrogliosis

Bipolar Disorders, EarlyView.
ABSTRACT Background Recent advances now allow detection of brain‐specific proteins in blood, including neurofilament light chain (NfL), a marker of axonal pathology, and glial fibrillary acidic protein (GFAP), indicative of astrocytic activation. Given the evidence of astroglial pathology and neuronal dysfunction in bipolar disorder, and ongoing ...
Matthew J. Y. Kang, Dhamidhu Eratne, Olivia Dean, Michael Berk, Adam J. Walker, Cassandra Wannan, Charles B. Malpas, Claudia Cicognola, Shorena Janelidze, Oskar Hansson, Jasleen Grewal, Philip B. Mitchell, Malcolm Hopwood, Christos Pantelis, Alexander F. Santillo, Dennis Velakoulis   +15 more
wiley   +1 more source

Disruption of the MAP1B-related Protein FUTSCH Leads to Changes in the Neuronal Cytoskeleton, Axonal Transport Defects, and Progressive Neurodegeneration inDrosophila [PDF]

, 2005
Alexandre Bettencourt da Cruz, Martin Schwärzel, Sabine Schulze, Mahtab Niyyati, Martin Heisenberg, Doris Kretzschmar   +5 more
openalex   +1 more source