Results 141 to 150 of about 174,919 (258)
Neurobiology of Disease, 2015 Nerve injury can lead to axonal regeneration, axonal degeneration, and/or neuronal cell death. Remarkably, the MAP3K dual leucine zipper kinase, DLK, promotes each of these responses, suggesting that DLK is a sensor of axon injury.
Vera Valakh +4 more
doaj
Electron tomography of paranodal septate-like junctions and the associated axonal and glial cytoskeletons in the central nervous system [PDF]
, 2010 Andrea Nans +3 more
openalex +1 more source
BDNF controls phosphorylation and transcriptional networks governing cytoskeleton organization and axonal regeneration [PDF]
, 2023 Jose Norberto S. Vargas +19 more
openalex +1 more source
Molecular Autism, 2019 Background Although neuronal extracellular sensing is emerging as crucial for brain wiring and therefore plasticity, little is known about these processes in neurodevelopmental disorders.
Ilaria Tonazzini +5 more
doaj +1 more source
The effects of cyclical simulation on the axon hillock diameter of murine intracortical neurons [PDF]
arXiv, 2018 Changes to the axon hillock in frequently firing neurons are known to be important predictors of early disease states. Studying this phenomenon is critical to understanding the first insult implicated in multiple neuro-degenerative disorders. To study these changes we used cyclical stimulations using micro-electrodes to the axon hillock of mouse ...
arxiv
ERNEST COST action overview on the (patho)physiology of GPCRs and orphan GPCRs in the nervous system
British Journal of Pharmacology, EarlyView.G protein‐coupled receptors (GPCRs) are a large family of cell surface receptors that play a critical role in nervous system function by transmitting signals between cells and their environment. They are involved in many, if not all, nervous system processes, and their dysfunction has been linked to various neurological disorders representing important
Necla Birgül Iyison +15 more
wiley +1 more source
The Dual Roles of Lamin A/C in Macrophage Mechanotransduction
Cell Proliferation, EarlyView.Compressive force can inhibit the expression of lamin A/C, SUN1 and SUN2 in macrophages. Lamin A deficiency may participate in mechanotransduction within macrophages through two distinct mechanisms. ABSTRACT Cellular mechanotransduction is a complex physiological process that integrates alterations in the external environment with cellular behaviours ...
Yao Wang +5 more
wiley +1 more source
In vitro models of valproic acid to assess neurodevelopmental toxicity: A scoping review
Epilepsia, EarlyView.Abstract Valproic acid (VPA) is a first‐line antiseizure medication (ASM) that is highly efficacious for treating generalized and focal epilepsy disorders. Unfortunately, due to its strong association with teratogenic effects culminating in fetal valproate spectrum disorder (FVSD), which may include neurocognitive and neurobehavioral deficits, the drug
Daniel Sandvik +5 more
wiley +1 more source
Epilepsia, EarlyView.Abstract Objective Mild malformations of cortical development with oligodendroglial hyperplasia in epilepsy (MOGHE) are brain lesions associated with focal epilepsy and characterized by increased oligodendroglial density, heterotopic neurons, and hypomyelination in the white matter.
Isabella C. Galvão +10 more
wiley +1 more source