Results 151 to 160 of about 174,919 (258)

A genome‐wide association study for recurrent laryngeal neuropathy in the Thoroughbred horse identifies a candidate gene that regulates myelin structure

Equine Veterinary Journal, EarlyView.
Abstract Background Equine recurrent laryngeal neuropathy (RLN) is an economically important upper respiratory tract (URT) disease with a genetic contribution to risk, but genetic variants independent of height have not been identified for Thoroughbreds.
Charlotte L. McGivney, Beatrice A. McGivney, Gabriella Farries, Katie F. Gough, Haige Han, Amy R. Holtby, David E. MacHugh, Lisa Michelle Katz, Emmeline W. Hill   +8 more
wiley   +1 more source

Activating AMPK improves pathological phenotypes due to mtDNA depletion

The FEBS Journal, EarlyView.
In a cellular model of mitochondrial disease characterized by progressive mitochondrial DNA (mtDNA) depletion, we found that advancing mitochondrial dysfunction triggers the early and specific activation of the mitochondria‐associated pool of AMP‐activated protein kinase (AMPK), a master regulator of energy homeostasis.
Gustavo Carvalho, Tran V. H. Nguyen, Bruno Repolês, Josefin M. E. Forslund, W. M. Ruchitha Rukmal Wijethunga, Farahnaz Ranjbarian, Isabela C. Mendes, Choco Michael Gorospe, Namrata Chaudhari, Micol Falabella, Mara Doimo, Sjoerd Wanrooij, Robert D. S. Pitceathly, Anders Hofer, Paulina H. Wanrooij   +14 more
wiley   +1 more source

Dual role for pannexin 1 at synapses: regulating functional and morphological plasticity

The Journal of Physiology, EarlyView.
Abstract figure legend Pannexin 1 (PANX1) regulation of dendritic spines. The postnatal decrease in PANX1 expression could release key spine cytoskeleton‐regulating proteins enabling spine stabilization. Does the physiological decrease in neuronal PANX1 levels across brain development underlie dendritic spine maturation?
Adriana Casillas Martinez, Leigh E. Wicki‐Stordeur, Annika V. Ariano, Leigh Anne Swayne   +3 more
wiley   +1 more source

Exploring neuronal mechanisms of osteosarcopenia in older adults

The Journal of Physiology, EarlyView.
Abstract figure legend The mechanosensitive osteocytic network within the bone matrix acts as a receptor and plays a crucial role in the functional adaptation of bone to mechanical loading. Through mechanotransduction, osteocytes convert mechanical impulses into electrical signals, which are transmitted via afferent nerves to sympathetic preganglionic ...
Ilhan Karacan, Kemal Sıtkı Türker
wiley   +1 more source

The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

The Journal of Physiology, EarlyView.
Abstract figure legend The synaptic vesicle cluster acts as a master regulator of synaptic structure and function, through various involvements in processes that range from synaptic initiation to plasticity and synaptic loss. Abstract The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter ...
Sofiia Reshetniak, Cristian A. Bogaciu, Stefan Bonn, Nils Brose, Benjamin H. Cooper, Elisa D'Este, Michael Fauth, Rubén Fernández‐Busnadiego, Maksims Fiosins, André Fischer, Svilen V. Georgiev, Stefan Jakobs, Stefan Klumpp, Sarah Köster, Felix Lange, Noa Lipstein, Victor Macarrón‐Palacios, Dragomir Milovanovic, Tobias Moser, Marcus Müller, Felipe Opazo, Tiago F. Outeiro, Constantin Pape, Viola Priesemann, Peter Rehling, Tim Salditt, Oliver Schlüter, Nadja Simeth, Claudia Steinem, Tatjana Tchumatchenko, Christian Tetzlaff, Marilyn Tirard, Henning Urlaub, Carolin Wichmann, Fred Wolf, Silvio O. Rizzoli   +35 more
wiley   +1 more source

Membrane trafficking of synaptic adhesion molecules

The Journal of Physiology, EarlyView.
Abstract figure legend Synaptic cellular adhesion molecules are surface transmembrane receptors that have been shown to internalize via endocytosis, and possibly also recycle, in a process that has been linked to the function and the turnover of the synaptic contact site.
Cristian A. Bogaciu, Silvio O. Rizzoli
wiley   +1 more source

A Diffusion MRI model for axonal damage quantification based on axial diffusivity reduction in axons: a Monte Carlo simulation study [PDF]

arXiv
Axonal damage is the primary pathological correlate of long-term impairment in multiple sclerosis (MS). Previous work has demonstrated a strong, quantitative relationship between decrease in axial diffusivity and axonal damage. In the present work, we develop an extension of diffusion basis spectrum imaging (DBSI) which can be used to quantify the ...
arxiv  

Volitional exercise elicits physiological and molecular improvements in the severe D2.mdx mouse model of Duchenne muscular dystrophy

The Journal of Physiology, EarlyView.
Abstract figure legend This study investigated the effects of volitional exercise on muscle health in the more severe D2.mdx model of Duchenne muscular dystrophy (DMD). We showed that 8–10 weeks of a relatively high volume of voluntary wheel running (VWR) in D2.mdx animals augmented select muscle mass and normalized ex vivo muscle force compared to ...
Stephanie R. Mattina, Sean Y. Ng, Andrew I. Mikhail, Derek W. Stouth, Cora E. Jornacion, Irena A. Rebalka, Thomas J. Hawke, Vladimir Ljubicic   +7 more
wiley   +1 more source

The Fragile X Messenger Ribonucleoprotein 1 Regulates the Morphology and Maturation of Human and Rat Oligodendrocytes

Glia, Volume 73, Issue 6, Page 1203-1220, June 2025.
Main Points Loss of FMRP impairs human and rat oligodendrocyte (OL) morphology in vitro. FMRP‐deficient OLs show impaired maturation when engrafted in hypomyelinated mice. Rat Fmr1 knockout OLs show a delay in myelin sheath formation in vivo. ABSTRACT The Fragile X Messenger Ribonucleoprotein (FMRP) is an RNA binding protein that regulates the ...
Vidya Ramesh, Eleni Tsoukala, Ioanna Kougianou, Zrinko Kozic, Karen Burr, Biju Viswanath, David Hampton, David Story, Bharath Kumar Reddy, Rakhi Pal, Owen Dando, Peter C. Kind, Sumantra Chattarji, Bhuvaneish T. Selvaraj, Siddharthan Chandran, Lida Zoupi   +15 more
wiley   +1 more source

Considerations and recommendations from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 3—Ex vivo imaging: Data processing, comparisons with microscopy, and tractography

Magnetic Resonance in Medicine, Volume 93, Issue 6, Page 2561-2582, June 2025.
Abstract Preclinical diffusion MRI (dMRI) has proven value in methods development and validation, characterizing the biological basis of diffusion phenomena, and comparative anatomy. While dMRI enables in vivo non‐invasive characterization of tissue, ex vivo dMRI is increasingly being used to probe tissue microstructure and brain connectivity.
Kurt G. Schilling, Amy F. D. Howard, Francesco Grussu, Andrada Ianus, Brian Hansen, Rachel L. C. Barrett, Manisha Aggarwal, Stijn Michielse, Fatima Nasrallah, Warda Syeda, Nian Wang, Jelle Veraart, Alard Roebroeck, Andrew F. Bagdasarian, Cornelius Eichner, Farshid Sepehrband, Jan Zimmermann, Lucas Soustelle, Christien Bowman, Benjamin C. Tendler, Andreea Hertanu, Ben Jeurissen, Marleen Verhoye, Lucio Frydman, Yohan van de Looij, David Hike, Jeff F. Dunn, Karla Miller, Bennett A. Landman, Noam Shemesh, Adam Anderson, Emilie McKinnon, Shawna Farquharson, Flavio Dell'Acqua, Carlo Pierpaoli, Ivana Drobnjak, Alexander Leemans, Kevin D. Harkins, Maxime Descoteaux, Duan Xu, Hao Huang, Mathieu D. Santin, Samuel C. Grant, Andre Obenaus, Gene S. Kim, Dan Wu, Denis Le Bihan, Stephen J. Blackband, Luisa Ciobanu, Els Fieremans, Ruiliang Bai, Trygve B. Leergaard, Jiangyang Zhang, Tim B. Dyrby, G. Allan Johnson, Julien Cohen‐Adad, Matthew D. Budde, Ileana O. Jelescu   +57 more
wiley   +1 more source