Whirlin, a cytoskeletal scaffolding protein, stabilizes the paranodal region and axonal cytoskeleton in myelinated axons. [PDF]
BMC Neurosci, 2013 BackgroundMyelinated axons are organized into distinct subcellular and molecular regions. Without proper organization, electrical nerve conduction is delayed, resulting in detrimental physiological outcomes.
Green JA +4 more
europepmc +6 more sources
Spectrins in Axonal Cytoskeletons: Dynamics Revealed by Extensions and Fluctuations [PDF]
The Journal of Chemical Physics, 2013 The macroscopic properties, the properties of individual components and how those components interact with each other are three important aspects of a composited structure. An understanding of the interplay between them is essential in the study of complex systems.
Lipeng Lai, Jianshu Cao
arxiv +9 more sources
Distribution pattern of axonal cytoskeleton proteins in the human optic nerve head.
Neural Regen Res, 2015 Glaucoma is one of the leading causes of blindness in the developed world. It is a progressive optic neuropathy where structural loss of retinal ganglion cell (RGC) axons corresponds with functional visual field defect.
Kang MH, Yu DY.
europepmc +3 more sources
The transport and assembly of the axonal cytoskeleton. [PDF]
The Journal of cell biology, 1989 ERV~ cells display a number of unusual properties which are generally viewed as adaptations to their extreme length and regional specialization. The dense and highly organized neurofilament (NF) ~ and microtubule (MT) arrays which serve to support nerve axons provide one example; another is the phenomenon of axonal transport, by which macromolecules ...
Peter J. Hollenbeck
semanticscholar +5 more sources
Formation of Compact Myelin Is Required for Maturation of the Axonal Cytoskeleton [PDF]
The Journal of Neuroscience, 1999 Although traditional roles ascribed to myelinating glial cells are structural and supportive, the importance of compact myelin for proper functioning of the nervous system can be inferred from mutations in myelin proteins and neuropathologies associated with loss of myelin.
Scott T. Brady +6 more
semanticscholar +8 more sources
Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions [PDF]
Journal of Neuroinflammation, 2006 Background Multiple sclerosis (MS) is a central nervous system-specific autoimmune, demyelinating and neurodegenerative disease. Infiltration of lesions by autoaggressive, myelin-specific CD4+Th1 cells correlates with clinical manifestations of disease ...
Cai Juan +3 more
doaj +3 more sources
Stable polymers of the axonal cytoskeleton: the axoplasmic ghost. [PDF]
The Journal of cell biology, 1982 We have examined the monomer-polymer equilibria which form the cytoskeletal polymers in squid axoplasm by extracting protein at low concentrations of monomer. The solution conditions inside the axon were matched as closely as possible by the extraction buffer (buffer P) to preserve the types of protein associations that occur in axoplasm.
James R. Morris, Raymond J. Lasek
semanticscholar +4 more sources
A Distal Axonal Cytoskeleton Forms an Intra-Axonal Boundary that Controls Axon Initial Segment Assembly [PDF]
Cell, 2012 AnkyrinG (ankG) is highly enriched in neurons at axon initial segments (AISs) where it clusters Na(+) and K(+) channels and maintains neuronal polarity. How ankG becomes concentrated at the AIS is unknown. Here, we show that as neurons break symmetry, they assemble a distal axonal submembranous cytoskeleton, comprised of ankyrinB (ankB), αII-spectrin ...
Mauricio R. Galiano +8 more
semanticscholar +6 more sources
Cytoskeleton and Membrane Organization at Axon Branches [PDF]
Frontiers in Cell and Developmental Biology, 2021 Axon branching is a critical process ensuring a high degree of interconnectivity for neural network formation. As branching occurs at sites distant from the soma, it is necessary that axons have a local system to dynamically control and regulate axonal ...
Satish Bodakuntla +4 more
doaj +3 more sources
The formin DAAM is required for coordination of the actin and microtubule cytoskeleton in axonal growth cones [PDF]
Journal of Cell Science, 2017 Directed axonal growth depends on correct coordination of the actin and microtubule cytoskeleton in the growth cone. However, despite the relatively large number of proteins implicated in actin−microtubule crosstalk, the mechanisms whereby actin ...
Szilárd Szikora +10 more
semanticscholar +4 more sources