Results 211 to 220 of about 174,919 (258)
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Abnormalities of the axonal cytoskeleton in giant axonal neuropathy
Journal of Neurocytology, 1988Intermediate filaments accumulate abnormally in a variety of cell types in individuals with human inherited giant axonal neuropathy (GAN). A characteristic feature of this disorder is the occurrence of focal axonal enlargements filled with accumulations of neurofilaments.
P. K. Thomas +3 more
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The role of axonal cytoskeleton in diabetic neuropathy.
Neurochemical research, 1997The neuropathy associated with diabetes includes well documented impairment of axonal transport, a reduction in axon calibre and a reduced capacity for nerve regeneration. All of those aspects of nerve function rely on the integrity of the axonal cytoskeleton.
W. Mclean
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Neurotoxic probes of the axonal cytoskeleton
Trends in Neurosciences, 1983Abstract Neurofibrillary changes, characterized by accumulations of neurofilaments within the neuronal perikaryon or axon, occur in a variety of human and experimental disorders. The pathogenesis of one model, β,β′-iminodipropionitrile (IDPN) toxicity, is partially understood. IDPN produces a distinctive alteration in which microtubules are segregated
Paul N. Hoffman +2 more
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Axonal degeneration and disorders of the axonal cytoskeleton
1995Abstract This chapter discusses cytoskeletal changes in axonal degeneration. It begins with a review of the organization of the normal axonal cytoskeleton, followed by a summary of the current understanding of Wallerian degeneration. It then considers the slowly evolving axonal degenerations in which alterations in neurofilament content ...
Edwin B. George +3 more
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Post-Acute Alterations in the Axonal Cytoskeleton after Traumatic Axonal Injury
Journal of Neurotrauma, 2003All previous analyses of axonal responses to traumatic axonal injury (TAI) have described the ultrastructure of changes in the cytoskeleton and axolemma within 6 h of injury. In the present study we tested the hypothesis that there are, in addition, ultrastructural pathological changes up to 1 week after injury.
Aisha Domleo +4 more
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Effects of PMP22 duplication and deletions on the axonal cytoskeleton
Annals of Neurology, 1999Axonal loss in Charcot-Marie-Tooth type 1A (CMT1A) is an important feature correlated with the functional disability in affected individuals. It is not known, however, how the most common genetic defect in Schwann cells (PMP22 duplication) causes the CMT1A phenotype and results in axonal loss.
Lei Chen +2 more
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Axonal cytoskeleton changes in experimental optic neuritis
Brain Research, 1999Axonal loss and degeneration in multiple sclerosis (MS) and experimental allergic encephalomyelitis (EAE) have been suggested by brain imaging, pathological and axonal transport studies. Further elucidation of the processes and mechanisms of axonal degeneration in demyelinating diseases is therefore of potential importance in order to alleviate the ...
L. F. Kastrukoff +7 more
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Neuropathology and Applied Neurobiology, 1989 Progressive axonopathy: an inherited neuropathy of Boxer dogs.
Ian R. Griffiths +2 more
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Calcium-Activated Protease and the Regulation of the Axonal Cytoskeleton
1984The synthesis, assembly, and intracellular dissemination of a prominent and elaborate cytoskeleton are basic properties of neurons that enable these cells to establish and maintain a highly asymmetric cell form. Variations in size and shape among different neurons are determined by the quantity and quality of their cytoskeletal components.
William W. Schlaepfer +1 more
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Organization of axonal cytoskeletons in squid giant axons
Neuroscience Research Supplements, 1990 Gen Matsumoto, Shöichiro Tsukita
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