Results 21 to 30 of about 25,196 (259)
Adenomatous polyposis coli regulates axon arborization and cytoskeleton organization via its N-terminus. [PDF]
PLoS ONE, 2011 Conditional deletion of APC leads to marked disruption of cortical development and to excessive axonal branching of cortical neurons. However, little is known about the cell biological basis of this neuronal morphological regulation.
Youjun Chen +3 more
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Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach
Biomolecules, 2021 Existent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilaments ...
Md Ishak Khan +3 more
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The Role of Spastin in Axon Biology
Frontiers in Cell and Developmental Biology, 2022 Neurons are highly polarized cells with elaborate shapes that allow them to perform their function. In neurons, microtubule organization—length, density, and dynamics—are essential for the establishment of polarity, growth, and transport. A mounting body
Ana Catarina Costa +2 more
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Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury
Mediators of Inflammation, 2023 Axonal regeneration has been the research focus in the field of clinical treatment for spinal cord injury (SCI). The growth and extension of neuronal axons is a dynamic biological process mediated by the cytoskeleton, and microtubule plays an important ...
Baoguo Liu, Sumei Liu, Dejun Sun
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CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway
eLife, 2021 Neurodevelopmental axonal pathfinding plays a central role in correct brain wiring and subsequent cognitive abilities. Within the growth cone, various intracellular effectors transduce axonal guidance signals by remodeling the cytoskeleton. Semaphorin-3E
Benoît Boulan +12 more
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Cytoskeleton dynamics in axon regeneration
Current Opinion in Neurobiology, 2018 Recent years have seen cytoskeleton dynamics emerging as a key player in axon regeneration. The cytoskeleton, in particular microtubules and actin, ensures the growth of neuronal processes and maintains the singular, highly polarized shape of neurons. Following injury, adult central axons are tipped by a dystrophic structure, the retraction bulb, which
Blanquie, Oriane, Bradke, Frank
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Cytoskeleton: Axons Earn Their Stripes [PDF]
Current Biology, 2013 Axons must be supported by a strong and flexible cytoskeleton. New 'super-resolution' imaging of the submembranous axonal cytoskeleton reveals that it is organized in a periodic, ladder-like structure with alternating rings of actin linked together by intervening complexes of spectrin.
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Mitochondria Coordinate Sites of Axon Branching through Localized Intra-axonal Protein Synthesis
Cell Reports, 2013 The branching of axons is a fundamental aspect of nervous system development and neuroplasticity. We report that branching of sensory axons in the presence of nerve growth factor (NGF) occurs at sites populated by stalled mitochondria.
Mirela Spillane +4 more
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Axonal plasticity in response to active forces generated through magnetic nano-pulling
Cell Reports, 2023 Summary: Mechanical force is crucial in guiding axon outgrowth before and after synapse formation. This process is referred to as “stretch growth.” However, how neurons transduce mechanical input into signaling pathways remains poorly understood. Another
Alessandro Falconieri +12 more
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Neural Plasticity, 2015 Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and ...
Minghui Tan +7 more
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