Herpes simplex virus-1 utilizes the host actin cytoskeleton for its release from axonal growth cones
PLoS Pathogens, 2022 Herpes simplex virus type 1 (HSV-1) has evolved mechanisms to exploit the host cytoskeleton during entry, replication and exit from cells. In this study, we determined the role of actin and the molecular motor proteins, myosin II and myosin V, in the ...
Kevin Danastas +5 more
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Differential requirement of F-actin and microtubule cytoskeleton in cue-induced local protein synthesis in axonal growth cones [PDF]
Neural Development, 2015 Local protein synthesis (LPS) via receptor-mediated signaling plays a role in the directional responses of axons to extrinsic cues. An intact cytoskeleton is critical to enact these responses, but it is not known whether the two major cytoskeletal ...
Michael Piper +6 more
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Erratum: The nano-architecture of the axonal cytoskeleton [PDF]
Nature Reviews Neuroscience, 2017 Nature Reviews Neuroscience 18, 713–726 (2017) In Box 1 of this article, the sentence “Actin filaments are approximately 8 nm in diameter, are composed of heterodimers of α-actin and β-actin (known as G-actin) and require ATP for polymerization” should have read “Actin filaments are approximately 8 nm in diameter, are composed of actin monomers (known ...
Christophe Leterrier +2 more
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The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma [PDF]
Acta Neuropathologica, 2011 The neurodegenerative disease glaucoma is characterised by the progressive death of retinal ganglion cells (RGCs) and structural damage to the optic nerve (ON).
Glyn Chidlow +3 more
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Netrin-1 stimulated axon growth requires the polyglutamylase TTLL1 [PDF]
Frontiers in NeuroscienceIntroductionIn the developing brain, neurons extend an axonal process through a complex and changing environment to form synaptic connections with the correct targets in response to extracellular cues.
Kyle R. Northington +2 more
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Modulation of the axonal microtubule cytoskeleton by myelinating Schwann cells [PDF]
The Journal of Neuroscience, 1994 The Trembler PNS myelin-deficient mutant mouse offers a unique model for the study of axon-glial interactions. Previous work in our laboratory on Trembler mouse sciatic nerve established that myelinating Schwann cells exert a profound effect on the underlying neuronal cytoskeleton.
LL Kirkpatrick, ST Brady
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Axonal transport of cytoskeleton and cytoskeleton regulatory cargo proteins in neurodegenerative disorders [PDF]
OA Anatomy, 2013 Introduction Axonal transport, an essential means of organelle and molecule transportation along the nerve fibre from and towards the cell body, is instrumental for neuronal viability and function. Defective axonal transport has been linked to a number of neurodegenerative diseases such as: Alzheimer’s, Parkinson’s, Huntington’s, motor neuron disorder,
JK Juranek
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Abnormalities in the axonal cytoskeleton induced by a connexin32 mutation in nerve xenografts [PDF]
Journal of Neuroscience Research, 1998 The X‐linked form of Charcot‐Marie‐Tooth neuropathy is associated with mutations in the connexin32 (Cx32) gene. The functional role of Cx32 in Schwann cells and the relationship of these mutations to the progressive axonal loss and distal limb weakness ...
Zarife Sahenk, Lei Chen
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Molecular Dissection of DAAM Function during Axon Growth in Drosophila Embryonic Neurons
Cells, 2022 Axonal growth is mediated by coordinated changes of the actin and microtubule (MT) cytoskeleton. Ample evidence suggests that members of the formin protein family are involved in the coordination of these cytoskeletal rearrangements, but the molecular ...
István Földi +7 more
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Active elasticity drives the formation of periodic beading in damaged axons [PDF]
Physical Review E 104.2 (2021): 024417, 2021 In several pathological conditions, such as coronavirus infections, multiple sclerosis, Alzheimer's and Parkinson's diseases, the physiological shape of axons is altered and a periodic sequence of bulges appears. Experimental evidences suggest that such morphological changes are caused by the disruption of the microtubules composing the cytoskeleton of
arxiv +1 more source