Results 31 to 40 of about 46,319 (290)

Wnt Signalling Promotes Actin Dynamics during Axon Remodelling through the Actin-Binding Protein Eps8. [PDF]

PLoS ONE, 2015
Upon arrival at their synaptic targets, axons slow down their growth and extensively remodel before the assembly of presynaptic boutons. Wnt proteins are target-derived secreted factors that promote axonal remodelling and synaptic assembly.
Eleanna Stamatakou, Monica Hoyos-Flight, Patricia C Salinas   +2 more
doaj   +1 more source

Unraveling axonal mechanisms of traumatic brain injury

Acta Neuropathologica Communications, 2022
Axonal swellings (AS) are one of the neuropathological hallmark of axonal injury in several disorders from trauma to neurodegeneration. Current evidence proposes a role of perturbed Ca2+ homeostasis in AS formation, involving impaired axonal transport ...
Victorio M. Pozo Devoto, Valentina Lacovich, Monica Feole, Pratiksha Bhat, Jaroslav Chovan, Maria Čarna, Isaac G. Onyango, Neda Dragišić, Martina Sűsserová, Martin E. Barrios-Llerena, Gorazd B. Stokin   +10 more
doaj   +1 more source

Adenomatous polyposis coli regulates axon arborization and cytoskeleton organization via its N-terminus. [PDF]

PLoS ONE, 2011
Conditional deletion of APC leads to marked disruption of cortical development and to excessive axonal branching of cortical neurons. However, little is known about the cell biological basis of this neuronal morphological regulation.
Youjun Chen, Xu Tian, Woo-Yang Kim, William D Snider   +3 more
doaj   +1 more source

Viscoelastic Response of Neurofilaments: An Atomistic Simulation Approach

Biomolecules, 2021
Existent literature has limitations regarding the mechanical behavior of axonal cytoskeletal components in a high strain rate scenario, which is mainly due to limitations regarding the structure of some components such as tau protein and neurofilaments ...
Md Ishak Khan, Fuad Hasan, Khandakar Abu Hasan Al Mahmud, Ashfaq Adnan   +3 more
doaj   +1 more source

The Role of Spastin in Axon Biology

Frontiers in Cell and Developmental Biology, 2022
Neurons are highly polarized cells with elaborate shapes that allow them to perform their function. In neurons, microtubule organization—length, density, and dynamics—are essential for the establishment of polarity, growth, and transport. A mounting body
Ana Catarina Costa, Ana Catarina Costa, Monica Mendes Sousa   +2 more
doaj   +1 more source

Morphology and Nanomechanics of Sensory Neurons Growth Cones following Peripheral Nerve Injury [PDF]

, 2012
A prior peripheral nerve injury in vivo, promotes a rapid elongated mode of sensory neurons neurite regrowth in vitro. This in vitro model of conditioned axotomy allows analysis of the cellular and molecular mechanisms leading to an improved neurite re ...
A Nilsson, A Vinckier, AB Huber, AB Mathur, AL Weisenhorn, AR Bausch, Attila-Gergely Végh, B Geiger, C Hilaire, ChC Dupont-Gillain, Csilla Gergely, DM Suter, DS Smith, E Evans, E Spedden, EW Dent, F Charron, Frédérique Scamps, H-J Butt, HA McNally, HA McNally, HJ Song, HS Xiao, I Mechaly, Igor Sokolov, IN Sneddon, J Dai, J Laishram, J Sleep, JL Goldberg, K Tanaka, KD Costa, L Lankford K, M Mustata, M Radmacher, M Radmacher, Marta Martin, MG Hertz, MJ Rosenbluth, Olivier Lucas, Ouafa Benzina, OV Chumakova, PN Hoffman, R García, R Lal, S Andre, S Pieraut, S Pieraut, SS Hannila, T Araki, T Tojima, TC Dickson, Thierry Cloitre, TS Lanero, V Heinrich, Vivien Szabo, Y Xiong, ZL Chen   +57 more
core   +21 more sources

Low-Dose Taxol Promotes Neuronal Axons Extension and Functional Recovery after Spinal Cord Injury

Mediators of Inflammation, 2023
Axonal regeneration has been the research focus in the field of clinical treatment for spinal cord injury (SCI). The growth and extension of neuronal axons is a dynamic biological process mediated by the cytoskeleton, and microtubule plays an important ...
Baoguo Liu, Sumei Liu, Dejun Sun
doaj   +1 more source

CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway

eLife, 2021
Neurodevelopmental axonal pathfinding plays a central role in correct brain wiring and subsequent cognitive abilities. Within the growth cone, various intracellular effectors transduce axonal guidance signals by remodeling the cytoskeleton. Semaphorin-3E
Benoît Boulan, Charlotte Ravanello, Amandine Peyrel, Christophe Bosc, Christian Delphin, Florence Appaix, Eric Denarier, Alexandra Kraut, Muriel Jacquier-Sarlin, Alyson Fournier, Annie Andrieux, Sylvie Gory-Fauré, Jean-Christophe Deloulme   +12 more
doaj   +1 more source

Estimation of electric field impact in deep brain stimulation from axon diameter distribution in the human brain [PDF]

Biomedical Physics & Engineering Express 2021, 2021
Background: Finite element method (FEM) simulations of the electric field magnitude (EF) are commonly used to estimate the affected tissue surrounding the active contact of deep brain stimulation (DBS) leads. Previous studies have found that DBS starts to noticeably activate axons at approximately 0.2 V/mm, corresponding to activation of 3.4 $\mu$m ...
arxiv   +1 more source

NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy [PDF]

, 2013
Alzheimer’s disease (AD) is a devastating neurodegenerative disease causing irreversible cognitive decline in the elderly. There is no disease-modifying therapy for this condition and the mechanisms underpinning neuronal dysfunction and neurodegeneration
Cowan, C.M., Mudher, A., Quraishe, S.
core   +1 more source