Results 31 to 40 of about 25,196 (259)
PLoS ONE, 2015 Upon arrival at their synaptic targets, axons slow down their growth and extensively remodel before the assembly of presynaptic boutons. Wnt proteins are target-derived secreted factors that promote axonal remodelling and synaptic assembly.
Eleanna Stamatakou +2 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: To investigate the mechanism that enables oxidative stress and cytoskeleton protein carbonylation to contribute to axonal dysfunction in traumatic brain injury (TBI).
Xiejun Zhang +8 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2018 In the adult nervous system axon caliber varies widely amongst different tracts. When considering a given axon, its diameter can further fluctuate in space and time, according to processes including the distribution of organelles and activity-dependent ...
Ana Rita Costa +4 more
doaj +1 more source
eLife, 2020 Neurons have a membrane periodic skeleton (MPS) composed of actin rings interconnected by spectrin. Here, combining chemical and genetic gain- and loss-of-function assays, we show that in rat hippocampal neurons the MPS is an actomyosin network that ...
Ana Rita Costa +17 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2017 Neurons are highly specialized cells of the nervous system that receive, process and transmit electrical signals critical for normal brain function.
Andrew D. Nelson +2 more
doaj +1 more source
The axonal actin-spectrin lattice acts as a tension buffering shock absorber
eLife, 2020 Axons span extreme distances and are subject to significant stretch deformations during limb movements or sudden head movements, especially during impacts.
Sushil Dubey +6 more
doaj +1 more source
Reversible Axonal Dystrophy by Calcium Modulation in Frataxin-Deficient Sensory Neurons of YG8R Mice
Frontiers in Molecular Neuroscience, 2017 Friedreich’s ataxia (FRDA) is a peripheral neuropathy involving a loss of proprioceptive sensory neurons. Studies of biopsies from patients suggest that axonal dysfunction precedes the death of proprioceptive neurons in a dying-back process.
Belén Mollá +22 more
doaj +1 more source
Role of calpains in the injury-induced dysfunction and degeneration of the mammalian axon
Neurobiology of Disease, 2013 Axonal injury and degeneration, whether primary or secondary, contribute to the morbidity and mortality seen in many acquired and inherited central nervous system (CNS) and peripheral nervous system (PNS) disorders, such as traumatic brain injury, spinal
Marek Ma
doaj +1 more source
Biology Open, 2014 Neurofilaments (NFs) are thought to provide structural support to mature axons via crosslinking of cytoskeletal elements mediated by the C-terminal region of the high molecular weight NF subunit (NF-H).
Sangmook Lee, Thomas B. Shea
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source