Results 41 to 50 of about 174,919 (258)
CRMP4-mediated fornix development involves Semaphorin-3E signaling pathway
eLife, 2021 Neurodevelopmental axonal pathfinding plays a central role in correct brain wiring and subsequent cognitive abilities. Within the growth cone, various intracellular effectors transduce axonal guidance signals by remodeling the cytoskeleton. Semaphorin-3E
Benoît Boulan +12 more
doaj +1 more source
Estimation of electric field impact in deep brain stimulation from axon diameter distribution in the human brain [PDF]
Biomedical Physics & Engineering Express 2021, 2021 Background: Finite element method (FEM) simulations of the electric field magnitude (EF) are commonly used to estimate the affected tissue surrounding the active contact of deep brain stimulation (DBS) leads. Previous studies have found that DBS starts to noticeably activate axons at approximately 0.2 V/mm, corresponding to activation of 3.4 $\mu$m ...
arxiv +1 more source
Cytoskeleton: Axons Earn Their Stripes [PDF]
Current Biology, 2013 Axons must be supported by a strong and flexible cytoskeleton. New 'super-resolution' imaging of the submembranous axonal cytoskeleton reveals that it is organized in a periodic, ladder-like structure with alternating rings of actin linked together by intervening complexes of spectrin.
openaire +3 more sources
Cytoskeleton dynamics in axon regeneration
Current Opinion in Neurobiology, 2018 Recent years have seen cytoskeleton dynamics emerging as a key player in axon regeneration. The cytoskeleton, in particular microtubules and actin, ensures the growth of neuronal processes and maintains the singular, highly polarized shape of neurons. Following injury, adult central axons are tipped by a dystrophic structure, the retraction bulb, which
Blanquie, Oriane, Bradke, Frank
openaire +3 more sources
Structure and evolution of neuronal wiring receptors and ligands
Developmental Dynamics, Volume 252, Issue 1, Page 27-60, January 2023., 2023 Abstract One of the fundamental properties of a neuronal circuit is the map of its connections. The cellular and developmental processes that allow for the growth of axons and dendrites, selection of synaptic targets, and formation of functional synapses use neuronal surface receptors and their interactions with other surface receptors, secreted ...
Elena Cortés +2 more
wiley +1 more source
Mitochondria Coordinate Sites of Axon Branching through Localized Intra-axonal Protein Synthesis
Cell Reports, 2013 The branching of axons is a fundamental aspect of nervous system development and neuroplasticity. We report that branching of sensory axons in the presence of nerve growth factor (NGF) occurs at sites populated by stalled mitochondria.
Mirela Spillane +4 more
doaj +1 more source
Neural Plasticity, 2015 Cytoskeleton dynamics are critical phenomena that underpin many fundamental cellular processes. Collapsin response mediator proteins (CRMPs) are highly expressed in the developing nervous system, mediating growth cone guidance, neuronal polarity, and ...
Minghui Tan +7 more
doaj +1 more source
Retinal regions shape human and murine Müller cell proteome profile and functionality
Glia, Volume 71, Issue 2, Page 391-414, February 2023., 2023 Main Points We defined Müller cells heterogeneity in the macular and peripheral human retina. Signaling pathways shaping this glial heterogeneity include proteins important for interaction with vesicular secretion, extracellular matrix and cell adhesion.
Lew Kaplan +15 more
wiley +1 more source
The axonal actin-spectrin lattice acts as a tension buffering shock absorber
eLife, 2020 Axons span extreme distances and are subject to significant stretch deformations during limb movements or sudden head movements, especially during impacts.
Sushil Dubey +6 more
doaj +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: To investigate the mechanism that enables oxidative stress and cytoskeleton protein carbonylation to contribute to axonal dysfunction in traumatic brain injury (TBI).
Xiejun Zhang +8 more
doaj +1 more source