Results 71 to 80 of about 174,919 (258)

Magnetic Field‐Assisted Conductive Nerve Guidance Conduit Enabling Peripheral Nerve Regeneration with Wireless Electrical Stimulation

Advanced Functional Materials, EarlyView.
This study introduces a conductive nerve guidance conduit integrated with wireless electrical stimulation through alternating magnetic fields, which induces currents and creates a supportive microenvironment for nerve regeneration. In vivo studies show that this approach significantly enhanced myelin restoration, gastrocnemius muscle regeneration ...
Shiheng Liu, Li‐Fang Zhu, Ming‐Wei Chang, Chao Li, Tingyu Wang, Rong Wang, Xinghao Yan, Baolin Wang   +7 more
wiley   +1 more source

The role of the cytoskeleton in volume regulation and beading transitions in PC12 neurites [PDF]

, 2010
We present investigations on volume regulation and beading shape transitions in PC12 neurites conducted using a flow-chamber technique. By disrupting the cell cytoskeleton with specific drugs we investigate the role of its individual components in the volume regulation response.
arxiv   +1 more source

Biomimetic Design of Biocompatible Neural Probes for Deep Brain Signal Monitoring and Stimulation: Super Static Interface for Immune Response‐Enhanced Contact

Advanced Functional Materials, EarlyView.
Ultrathin, flexible neural probes are developed with an innovative, biomimetic design incorporating brain tissue‐compatible materials. The material system employs biomolecule‐based encapsulation agents to mitigate inflammatory responses, as demonstrated through comprehensive in vitro and in vivo studies.
Jeonghwa Jeong, Gyeonghwa Heo, Young Woo Kwon, Seon Yeong Chae, Min Jae Kim, Ki Jun Yu, Hwa Kyoung Shin, Suck Won Hong   +7 more
wiley   +1 more source

Mutations in MYO9B are associated with Charcot–Marie–Tooth disease type 2 neuropathies and isolated optic atrophy

European Journal of Neurology, Volume 30, Issue 2, Page 511-526, February 2023., 2023
Abstract Background and purpose Charcot–Marie–Tooth disease (CMT) is a heterogeneous group of disorders caused by mutations in at least 100 genes. However, approximately 60% of cases with axonal neuropathies (CMT2) still remain without a genetic diagnosis. We aimed at identifying novel disease genes responsible for CMT2.
Silvia Cipriani, Marta Guerrero‐Valero, Stefano Tozza, Edward Zhao, Veith Vollmer, Danique Beijer, Matt Danzi, Cristina Rivellini, Dejan Lazarevic, Giovanni Battista Pipitone, Bianca Rose Grosz, Costanza Lamperti, Stefania Bianchi Marzoli, Paola Carrera, Marcella Devoto, Chiara Pisciotta, Davide Pareyson, Marina Kennerson, Stefano C. Previtali, Stephan Zuchner, Steven S. Scherer, Fiore Manganelli, Martin Bähler, Alessandra Bolino   +23 more
wiley   +1 more source

Tau interferes with axonal neurite stabilization and cytoskeletal composition independently of its ability to associate with microtubules

Biology Open, 2020
Tau impacts overall axonal transport particularly when overexpressed by interfering with translocation of kinesin along microtubules (MTs) and/or as a cargo of kinesin by outcompeting other kinesin cargo.
Edward F. Boumil, Rishel B. Vohnoutka, Sangmook Lee, Thomas B. Shea   +3 more
doaj   +1 more source

Mechanical Surface Waves Accompany Action Potential Propagation [PDF]

, 2014
Many studies have shown that a mechanical displacement of the axonal membrane accompanies the electrical pulse defining the Action Potential (AP). Despite a large and diverse body of experimental evidence, there is no theoretical consensus either for the physical basis of this mechanical wave nor its interdependence with the electrical signal.
arxiv   +1 more source

A model of fasciculation and sorting in mixed populations of axons [PDF]

Phys. Rev. E 84, 021908 (2011), 2010
We extend a recently proposed model (Chaudhuri et al., EPL 87, 20003 (2009)) aiming to describe the formation of fascicles of axons during neural development. The growing axons are represented as paths of interacting directed random walkers in two spatial dimensions.
arxiv   +1 more source

Sustained Release of Proteins Using Region‐Specific Tunable Degradability in Hydrogels through 3D Photopatterning and Complimentary Labile Bond Chemistry

Advanced Functional Materials, EarlyView.
A series of ultraviolet‐ and near‐infrared radiation sensitive photoactivatable hydrogels are developed that can be controlled spatiotemporally down to µm precisions using one‐ and two‐photon uncaging. The latent hydroxylamine‐, hydrazine‐, and amine uncaged moieties are used to photopattern a series of diverse proteins displaying complimentary ...
Tove Kivijärvi, Carmine P. Cerrato, Taha Behroozi Kohlan, Paul O’Callaghan, Johan Kreuger, Marie Arsenian‐Henriksson, Anna Finne‐Wistrand   +6 more
wiley   +1 more source

Rescuing axons from degeneration does not affect retinal ganglion cell death

Brazilian Journal of Medical and Biological Research, 2016
After a traumatic injury to the central nervous system, the distal stumps of axons undergo Wallerian degeneration (WD), an event that comprises cytoskeleton and myelin breakdown, astrocytic gliosis, and overexpression of proteins that inhibit axonal ...
S. de Lima, B.S. Mietto, C. Paula, T. Muniz, A.M.B. Martinez, P.F. Gardino   +5 more
doaj   +1 more source

Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton. [PDF]

PLoS ONE, 2012
Axon injury and degeneration is a common consequence of diverse neurological conditions including multiple sclerosis, traumatic brain injury and spinal cord injury. The molecular events underlying axon degeneration are poorly understood.
Patrick Garland, Lucy J Broom, Shmma Quraishe, Paul D Dalton, Paul Skipp, Tracey A Newman, V Hugh Perry   +6 more
doaj   +1 more source