Results 71 to 80 of about 25,196 (259)

Progress of Research on Diffuse Axonal Injury after Traumatic Brain Injury

Neural Plasticity, 2016
The current work reviews the concept, pathological mechanism, and process of diagnosing of DAI. The pathological mechanism underlying DAI is complicated, including axonal breakage caused by axonal retraction balls, discontinued protein transport along ...
Junwei Ma, Kai Zhang, Zhimin Wang, Gang Chen   +3 more
doaj   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Tau protein and adult hippocampal neurogenesis

Frontiers in Neuroscience, 2012
Tau protein is a microtubule associated protein found in the axonal compartment that stabilizes neuronal microtubules under normal physiological conditions.
Almudena eFuster-Matanzo, Almudena eFuster-Matanzo, María eLlorens-Martín, María eLlorens-Martín, Jerónimo eJurado-Arjona, Jerónimo eJurado-Arjona, Jesus eAvila, Jesus eAvila, Félix eHernández, Félix eHernández   +9 more
doaj   +1 more source

A Conjugation Delivery System of Macrophages and Platelet Pharmacytes Promotes Regeneration After Spinal Cord Injury

Advanced Science, EarlyView.
A macrophage–platelet conjugation system (M‐P‐NPs@PPARγ) targets injure tissue to co‐deliver platelet mitochondria and PPARγ‐encoding NPs. This strategy boosts the macrophage energy supply and restores lipid homeostasis, leading to synergistically enhanced efferocytosis and tissue repair Abstract Mitochondrial dysfunction occurs in macrophages with ...
Haoli Wang, Hao Hu, Yijun Li, Lintao Hu, Chenhui Gu, Yiwei Zhu, Jing Huang, Na Li, Shuqi Jiang, Shouyan Zu, Jiachen Xu, Yining Wang, Ke Yang, Pengfei Chen, Liqing Shangguan, Yongcheng Wang, Shunwu Fan, Xianfeng Lin, Qingqing Wang   +18 more
wiley   +1 more source

Watery and dark axons in Wallerian degeneration of the opossum's optic nerve: different patterns of cytoskeletal breakdown?

Anais da Academia Brasileira de Ciências, 2001
In this paper we report a qualitative morphological analysis of Wallerian degeneration in a marsupial. Right optic nerves of opossums Didelphis marsupialis were crushed with a fine forceps and after 24, 48, 72, 96 and 168 hours the animals were ...
MARCELO S. NARCISO, JAN NORA HOKOÇ, ANA M. B. MARTINEZ   +2 more
doaj   +1 more source

Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function

Acta Neuropathologica Communications, 2020
Protein inclusions containing the RNA-binding protein TDP-43 are a pathological hallmark of amyotrophic lateral sclerosis and other neurodegenerative disorders.
Michael Briese, Lena Saal-Bauernschubert, Patrick Lüningschrör, Mehri Moradi, Benjamin Dombert, Verena Surrey, Silke Appenzeller, Chunchu Deng, Sibylle Jablonka, Michael Sendtner   +9 more
doaj   +1 more source

Coincident Fluorescence‐Burst Analysis of Actin Cargo Molecules in Secreted Single Diffusing Extracellular Vesicles From Human Induced Pluripotent Stem Cells

Advanced Science, EarlyView.
This study presents a two‐color FCCS and coincident‐burst analysis platform to quantify actin cargo in dual‐labeled EVs secreted from hiPSCs. The approach tracks secretion dynamics, confirms actin loading, and measures EV size and cargo number, offering insights into cytoskeletal disruption and neuronal differentiation relevant to neurodegenerative ...
Dang Du Nguyen, Aleksandr Barulin, Won Jong Yu, Jong‐Chan Park, Inki Kim   +4 more
wiley   +1 more source

Damage to Myelin and Oligodendrocytes: A Role in Chronic Outcomes Following Traumatic Brain Injury?

Brain Sciences, 2013
There is increasing evidence in the experimental and clinical traumatic brain injury (TBI) literature that loss of central myelinated nerve fibers continues over the chronic post-traumatic phase after injury.
William L. Maxwell
doaj   +1 more source

Label‐Free Molecular Characterization of Protein Aggregates in Differentiated Astrocytes

Advanced Science, EarlyView.
Mid‐infrared photothermal microscopy enables label‐free structural, molecular, and functional imaging of protein aggregates in astrocyte cells. The processes of astrocytes differentiated on a nanomaterial interface are characterized by α‐helical signatures combined with enhanced interfacial thermal resistance properties, while the cell soma of non ...
Panagis D. Samolis, Chiara Lazzarini, Rahmetullah Durgun, Barbara Barile, Giorgia Conte, Tamara Posati, Marco Caprini, Grazia Paola Nicchia, Valentina Benfenati, Michelle Y. Sander   +9 more
wiley   +1 more source

Osmotic Tension Asymmetry Drives Electrotactic Migration via PDLIM7‐Polarized Microfilament Coordination in Breast Cancer Cells

Advanced Science, EarlyView.
This study establishes an electric field‐induced directional migration model using fluorescence tension probes to visualize microfilament forces and intracellular osmotic pressure dynamics in the electrotactic migration of breast cancer cells. This model delineates how electromechanical interactions among membrane potential, ion channels, OP, traction ...
Ling Zhu, Zihui Zheng, Wang Li, Chenyi Shou, Ying Zhao, Lijun Zhang, Xiaoli Shi, Yunfeng Hu, Huanhuan Zhao, Huiwen Wu, Jun Guo   +10 more
wiley   +1 more source