Results 81 to 90 of about 174,919 (258)

Engineering the Future of Restorative Clinical Peripheral Nerve Surgery

Advanced Healthcare Materials, EarlyView.
What if damaged nerves could regenerate more effectively? This review unveils cutting‐edge strategies to restore nerve function, from biomaterial scaffolds and bioactive molecules to living engineered tissues. By accelerating axonal regrowth, preserving Schwann cells, and enhancing connectivity, these approaches are reshaping nerve repair—offering new ...
Justin C. Burrell, Zarina S. Ali, Eric L. Zager, Joseph M. Rosen, Mykhailo M. Tatarchuk, D. Kacy Cullen   +5 more
wiley   +1 more source

Microtubule-dependent ribosome localization in C. elegans neurons

eLife, 2017
Subcellular localization of ribosomes defines the location and capacity for protein synthesis. Methods for in vivo visualizing ribosomes in multicellular organisms are desirable in mechanistic investigations of the cell biology of ribosome dynamics. Here,
Kentaro Noma, Alexandr Goncharov, Mark H Ellisman, Yishi Jin   +3 more
doaj   +1 more source

Time-dependent effects of focal retinal ischemia on axonal cytoskeleton proteins.

Investigative Ophthalmology and Visual Science, 2010
PURPOSE To examine the time-dependent effects of focal axonal ischemia on the retinal ganglion cell (RGC) cytoskeleton. METHODS Eight pigs were used. Small retinal arteriolar branches were occluded by argon laser to induce focal ischemic insults that ...
Chandrakumar Balaratnasingam, W. Morgan, L. Bass, M. Kang, S. Cringle, Dao-Yi Yu   +5 more
semanticscholar   +1 more source

Functional Biomaterials Derived from Protein Liquid–Liquid Phase Separation and Liquid‐to‐Solid Transition

Advanced Materials, EarlyView.
Protein can undergo liquid–liquid phase separation and liquid‐to‐solid transition to form liquid condensates and solid aggregates. These phase transitions can be influenced by post‐translational modifications, mutations, and various environmental factors.
Tianchen Li, Dea Ilhamsyah, Benedict Tai, Yi Shen   +3 more
wiley   +1 more source

Omics Approach to Axonal Dysfunction of Motor Neurons in Amyotrophic Lateral Sclerosis (ALS)

Frontiers in Neuroscience, 2020
Amyotrophic lateral sclerosis (ALS) is an intractable adult-onset neurodegenerative disease that leads to the loss of upper and lower motor neurons (MNs). The long axons of MNs become damaged during the early stages of ALS.
Naoki Suzuki, Naoki Suzuki, Tetsuya Akiyama, Hitoshi Warita, Masashi Aoki   +4 more
doaj   +1 more source

Axon Membrane Skeleton Structure is Optimized for Coordinated Sodium Propagation [PDF]

PLOS Computational Biology, 13, Issue 2, e1005407, (2017), 2016
Axons transmit action potentials with high fidelity and minimal jitter. This unique capability is likely the result of the spatiotemporal arrangement of sodium channels along the axon. Super-resolution microscopy recently revealed that the axon membrane skeleton is structured as a series of actin rings connected by spectrin filaments that are held ...
arxiv   +1 more source

Advancements in Carbon‐Based Piezoelectric Materials: Mechanism, Classification, and Applications in Energy Science

Advanced Materials, EarlyView.
Carbon‐based piezoelectric materials are systematically categorized based on their structural and functional properties. The mechanisms of stress‐induced charge transfer are elucidated, and their applications are explored across three key domains: piezoelectric catalysis for energy conversion and environmental remediation, piezoelectric biomedical ...
Mude Zhu, Qingyou Liu, Wai‐Yeung Wong, Linli Xu   +3 more
wiley   +1 more source

Viscoelastic damage evaluation of the axon

Frontiers in Bioengineering and Biotechnology, 2022
In this manuscript, we have studied the microstructure of the axonal cytoskeleton and adopted a bottom-up approach to evaluate the mechanical responses of axons.
Fuad Hasan, KAH Al Mahmud, Md. Ishak Khan, Ashfaq Adnan   +3 more
doaj   +1 more source

Chemical AI in the Limelight: The Contribution of Photochromic Materials and Oscillatory Chemical Reactions

Advanced Optical Materials, EarlyView.
Photochromic compounds are versatile ingredients for the development of Chemical AI. When they are embedded in a tight microenvironment, they become Markov blankets. They are also valuable for processing Boolean and Fuzzy logic. They contribute to neuromorphic engineering in wetware based on opto‐chemical signals exchanged with oscillatory chemical ...
Pier Luigi Gentili
wiley   +1 more source

Analysis of the hypothalamic oxytocin system and oxytocin receptor‐expressing astrocytes in a mouse model of Prader–Willi syndrome

Journal of Neuroendocrinology, Volume 34, Issue 12, December 2022., 2022
If and how genetic disorders such as Prader‐Willi (PWS) or Schaaf‐Yang (SYS) syndromes affect oxytocinergic signaling is not well studied. In this study we used our established and well‐characterised Magel2 KO mouse model and analysed the number of oxytocin (OT) cells and OT receptor‐expressing (OTR) astrocytes.
Ferdinand Althammer, Moritz Claudius Wimmer, Quirin Krabichler, Stephanie Küppers, Jonas Schimmer, Henning Fröhlich, Laura Dötsch, Tim Gruber, Selina Wunsch, Tim Schubert, Matthew K. Kirchner, Javier E. Stern, Alexandre Charlet, Valery Grinevich, Christian P. Schaaf   +14 more
wiley   +1 more source