Results 181 to 190 of about 122,498 (328)

Carboxypeptidase H in the hypothalamo-neurohypophysial system: evidence for processing and activation of a prohormone-processing enzyme during axonal transport [PDF]

, 1990
VY Hook, H. Affolter, Miklós Palkovits
openalex   +1 more source

Post‐Translational Modified Neoantigens in Autoimmune Diseases: Challenges of Immune Tolerance

Advanced Science, EarlyView.
Autoimmune diseases have a high incidence and disability rate. The pathogenesis of autoimmune diseases involves the interaction among genetic factors, environmental factors, and immune disorders. The post‐translational modified neoantigens are the key nodal of these three factors. And these post‐translational modified neoantigens, after being presented
Yue Zhai, Kefei Wu, Qi Lin, Zhenzhen Cao, Yankun Jia, Ping Zhu   +5 more
wiley   +1 more source

hnRNP R regulates mitochondrial movement and membrane potential in axons of motoneurons

Neurobiology of Disease
Axonal mitochondria defects are early events in the pathogenesis of motoneuron disorders such as spinal muscular atrophy and amyotrophic lateral sclerosis.
Sophia Dithmar, Abdolhossein Zare, Saeede Salehi, Michael Briese, Michael Sendtner   +4 more
doaj  

Zn2+ decoration of microtubules arrests axonal transport and displaces tau, doublecortin, and MAP2C. [PDF]

J Cell Biol, 2023
Minckley TF, Salvagio LA, Fudge DH, Verhey K, Markus SM, Qin Y.   +5 more
europepmc   +1 more source

Functional Analysis of Dynactin and Cytoplasmic Dynein in Slow Axonal Transport [PDF]

, 1996
James F. Dillman, Lewis P. Dabney, Sher Karki, Bryce M. Paschal, Erika L.F. Holzbaur, K. Kevin Pfister   +5 more
openalex   +1 more source

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

Advanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu, Shengyu Jin, Xin Fu, Chong Xie, Yi Chen, Liangtang Chang, Yongheng Fan, Donghua He, Xiaoqi Hong, Xi Shen, Xiaoli Zheng, Qiyue Wang, Dao Shi, Fangyuan Li, Daishun Ling, Yangtai Guan, Neng Gong, Xiaoping Tong   +17 more
wiley   +1 more source

Amino Acid‐Sensing Neurons in the Anterior Piriform Cortex Control Brown Adipose Tissue Thermogenesis

Advanced Science, EarlyView.
This study identifies a class of amino acid‐sensing neurons, APCCRH neurons, which regulate BAT thermogenesis. Leucine deficiency alters intrinsic excitability through GCN2 signaling pathway, activating APCCRH neurons, which in turn regulate BAT thermogenesis via projections to the lateral hypothalamus.
Peixiang Luo, Kexin Tong, Yeting Gan, Min Tang, Yuguo Niu, Kan Liu, Shihong Ni, Shangming Wu, Xiaoxue Jiang, Haizhou Jiang, Fei Xiao, Shanghai Chen, Wei Lv, Xiaoying Li, Feixiang Yuan, Feifan Guo   +15 more
wiley   +1 more source

Small Extracellular Vesicles Orchestrate Cisplatin‐Induced Ototoxicity: Potential Biomarker and Targets Discovery

Advanced Science, EarlyView.
Cisplatin causes reactive oxygen species accumulation, leading to apoptosis and inflammation in cochlear hair cells. Small extracellular vesicles primarily derived from the damaged hair cells likely contribute to cisplatin‐induced ototoxicity, carrying a variety of microRNAs and proteins.
Jingru Ai, Shasha Zhang, Mingchen Dai, Pei Jiang, Jingyuan Huang, Hairong Xiao, Yanqin Lin, Xujun Tang, Wei Tong, Jun He, Qiuyue Mao, Yintao Wang, Zixuan Ye, Tian Wang, Renjie Chai   +14 more
wiley   +1 more source

Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport. [PDF]

Cells, 2023
König S, Schmidt N, Bechberger K, Morris S, Priego M, Zaky H, Song Y, Pielage J, Brunholz S, Brady ST, Kins S, Morfini G.   +11 more
europepmc   +1 more source

Sensory neurons selectively upregulate synthesis and transport of the beta III-tubulin protein during axonal regeneration [PDF]

, 1995
P. F. Moskowitz, MM Oblinger
openalex   +1 more source