Results 191 to 200 of about 68,755 (290)

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport. [PDF]

Cells, 2023
König S, Schmidt N, Bechberger K, Morris S, Priego M, Zaky H, Song Y, Pielage J, Brunholz S, Brady ST, Kins S, Morfini G.   +11 more
europepmc   +1 more source

Enhanced axonal transport: A novel form of “plasticity” after primate and rodent spinal cord injury

, 2017
J. H. Brock, E Rosenzweig, Hong Yang, Mark H. Tuszynski   +3 more
openalex   +2 more sources

Axonal transport and transcellular transfer of nucleosides and polyamines in intact and regenerating optic nerves of goldfish: speculation on the axonal regulation of periaxonal cell metabolism [PDF]

, 1982
N. A. Ingoglia, Sharma Sc, J Pilchman, K Baranowski, J. A. Sturman   +4 more
openalex   +1 more source

Unraveling the Morphological and Functional Maturation Mechanisms Underlying Human Neural Development Using iPSCs‐Derived Neuronal Model

Advanced Science, EarlyView.
Using human induced pluripotent stem cells (hiPSCs)‐derived neuronal model, Tian and colleagues reveal that voltage‐gated calcium channels Cav1.2 and Cav1.3, and their mediated calcium ion influx, are essential for early morphogenesis of human neuronal development, while ECEL1 underlies human neuronal functional developmental maturation through CALM3 ...
Yue Tian, Yi‐Chun Ou, Zi‐Xian Zhang, Jie Cai, Si‐Qing Cai, Guo‐Gang Xing   +5 more
wiley   +1 more source

Axonal transport of CHMP2b is regulated by kinesin-binding protein and disrupted by CHMP2b^intron5. [PDF]

Life Sci Alliance
Kirwan KR, Puerta-Alvarado V, Waites CL.
europepmc   +1 more source

The novel cargo Alcadein induces vesicle association of kinesin‐1 motor components and activates axonal transport [PDF]

, 2007
Yoichi Araki, Takanori Kawano, Hidenori Taru, Yuhki Saito, Sachiyo Wada, Kanako Miyamoto, Hisako Kobayashi, Hiroyuki Ishikawa, Yu Ohsugi, Tohru Yamamoto, Kenji Matsuno, Masataka Kinjo, Toshiharu Suzuki   +12 more
openalex   +1 more source

Alpinetin Nanoparticles Alleviate Optic Nerve Injury Induced by Acute Glaucoma via LRP1‐PPARγ Mediated Regulation of Microglial Lipid Metabolism

Advanced Science, EarlyView.
Microglial lipid metabolic dysfunction drives neurodegeneration in glaucoma. We found loss of LRP1 causes lipid accumulation and inflammation. We developed alpinetin‐loaded nanoparticles (AlpNPs) that bind LRP1, activate the PPARγ‐LXRα‐ABCA1 pathway to restore lipid homeostasis, promote an anti‐inflammatory phenotype, and protect retinal ganglion cells,
Miao Wei, Yujia Huo, Jingchang Yuan, Xiao Fan, Xiaochen Wang, Sisi Tan, Xi Gao, Ruotong Ouyang, Hong Li   +8 more
wiley   +1 more source

Deregulation of PKN1 activity disrupts neurofilament organisation and axonal transport [PDF]

, 2008
Catherine Manser, Alison Stevenson, Steven J. Banner, Jennifer Davies, Elizabeth L. Tudor, Yoshitaka Ono, P. Nigel Leigh, Declan M. McLoughlin, Christopher E. Shaw, Christopher C.J. Miller   +9 more
openalex   +1 more source

Identification and Mechanisms of Osteocyte Subsets Involved in the Pathological Progression of Osteoporosis

Advanced Science, EarlyView.
Osteocyte heterogeneity in bone remains poorly understood. This study identifies six distinct osteocyte subsets in mice, revealing a key subpopulation (BHR‐Ocys) that drives bone loss in osteoporosis. BHR‐Ocys promote osteoclast‐mediated resorption via a novel Sema5a‐Plxna1 signaling axis.
Zengxin Jiang, Biyu Rui, Xuecheng He, Jiajun Wang, Xiangdong Wu, Rui Shao, Xue Meng, Xiaochun Peng, Hengfeng Yuan   +8 more
wiley   +1 more source