Results 191 to 200 of about 271,417 (354)

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice [PDF]

open access: yes, 2019
Axonal degeneration (AxD) following nerve injury, chemotherapy, and in several neurological disorders is an active process driven by SARM1, an injury-activated NADase.
DiAntonio, Aaron   +8 more
core   +1 more source

Efficient and Realistic Brain Simulation: A Review and Design Guide for Memristor‐Based Approaches

open access: yesAdvanced Materials Technologies, EarlyView.
Memristor‐based emulation of Hodgkin‐Huxley neuron models is investigated, by defining the ideal device characteristics needed for accurate ion‐channel representation and reviewing existing works targeting memristive replication of biological realistic neural behavior.
Lennart Paul Liong Landsmeer   +5 more
wiley   +1 more source

A Diffusion MRI model for axonal damage quantification based on axial diffusivity reduction in axons: a Monte Carlo simulation study [PDF]

open access: yesarXiv
Axonal damage is the primary pathological correlate of long-term impairment in multiple sclerosis (MS). Previous work has demonstrated a strong, quantitative relationship between decrease in axial diffusivity and axonal damage. In the present work, we develop an extension of diffusion basis spectrum imaging (DBSI) which can be used to quantify the ...
arxiv  

Axon-axon and axon-target interactions underlying somatosensory circuit assembly in Drosophila

open access: yes, 2019
Sensory axons from functionally related neurons often project to similar regions in the central nervous system (CNS). Various cell-cell interactions and activity-dependent mechanisms contribute to the formation of these arrangements, but it remains unclear how they ultimately influence circuit wiring and function. I examined mechanisms of somatosensory
openaire   +3 more sources

Finding the axon

open access: yesThe Journal of Cell Biology, 2003
If you've seen one microtubule, you've seen them all. Not true, according to Nakata and Hirokawa, who demonstrate on page 1045 that a unique set of micro- tubules is crucial for protein targeting in neurons. Figure Vesicles move into the axon on a unique set of microtubules (green).
openaire   +2 more sources

Photoactive Monolayer MoS2 for Spiking Neural Networks Enabled Machine Vision Applications

open access: yesAdvanced Materials Technologies, EarlyView.
Molybdenum disulfide (MoS2) optoelectronic devices are implemented as Leaky Integrate‐and‐Fire (LIF) neurons in spiking neural networks (SNNs), where light‐induced photocurrent dynamics represent potentiation (τd) and depression (τd), emulating neuronal membrane potential.
Thiha Aung   +5 more
wiley   +1 more source

Microfluidic Spinning of PEDOT:PSS Microfibers for Nerve Guidance Conduits

open access: yesAdvanced Materials Technologies, EarlyView.
This publication explores the fabrication of microfluidically spun PEDOT:PSS microfibers for conductive nerve guidance conduits (NGCs). It details the spinning process, fiber characterization, and biocompatibility assessment. The study highlights the fibers' mechanical and electrical properties, non‐cytotoxicity, and potential for nerve regeneration or
Matthias Geiger   +8 more
wiley   +1 more source

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