Results 171 to 180 of about 224,860 (308)

The E3 Ubiquitin Ligase RLIM Safeguards Oligodendrocyte Development and Myelination by Targeting SLC7A11 for Polyubiquitination to Regulate Ferroptotic Resistance

Advanced Science, EarlyView.
RLIM‐mediated SLC7A11 polyubiquitination is required for SPTBN2‐mediated trafficking and membrane localization of SLC7A11, which enables oligodendrocyte precursor cells to be resistant to ferroptosis and safeguards oligodendrocyte lineage progression and thus myelination.
Yuwei Li, Haijun Zhang, Jieya Zhou, Shiyu Yang, Jingmei Cha, Gaofeng Yan, Shuhua Zhao, Bingyu Mao, Pengcheng Ma   +8 more
wiley   +1 more source

An axon-intrinsic loop restricts nerve regeneration through axonal protein synthesis. [PDF]

Sci Adv
Buchanan CN, Lee J, Matoo S, Headen JA, Honoree MC, Conway M, Thompson LF, Smith TP, McKay A, Tosadori C, Dalla Costa I, Lopez De Leon M, Thames E, Perrone-Bizzozero N, Kalinski AL, Welshhans K, Vaughn LS, Twiss JL.   +17 more
europepmc   +1 more source

Whole‐Genome Sequencing Pilot of the Central Asian Genomic Diversity Project Reveals Distinct Histories, Adaptation, and Introgression

Advanced Science, EarlyView.
As a pilot phase of the Central Asian Genomic Diversity Project, whole‐genome sequencing of 166 individuals from 20 Central Asian and Afghan Hazara populations reveals fine‐scale substructure shaped by repeated trans‐Eurasian migration and admixture. Integrated analyses uncover post‐admixture adaptation, archaic introgression, and medically relevant ...
Mengge Wang, Shuhan Duan, Qiuxia Sun, Renkuan Tang, Lintao Luo, Jie Zhong, Zhaxylyk Sabitov, CAGDP Consortium†, Lan‐Hai Wei, Chao Liu, Maxat Zhabagin, Guanglin He   +11 more
wiley   +1 more source

Evaluation of the Retinal Nerve Fiber Layer and Ganglion Cell Layer After Laser-Assisted in situ Keratomileusis, Femtosecond-Laser in-situ Keratomileusis, and Small Incision Lenticule Extraction Using Optical Coherence Tomography

Clinical Ophthalmology
Yasmine Maher Shaaban,1,2,* Tamer Abdel Fattah Badran1,3,* 1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Ain Shams Specialized Hospital, Cairo, 11588, Egypt; 3Eye Subspeciality Center (ESC), Cairo, 11402,
Shaaban YM, Badran TAF
doaj  

A Plant Photoregulator‐Inspired S‐Type Heterojunction System for Diabetic Keratopathy via Tri‐Modal Light‐Driven Immunometabolic Reprogramming, Tissue Repair, and Antibacterial Activity

Advanced Science, EarlyView.
To address the multifaceted imbalance in diabetic keratopathy, a light‐responsive biomimetic platform (WCNx‐Rh2) is developed and integrates glucose degradation, immune modulation, and antibacterial defense through a designed heterojunction and screened immunomodulator. WCNx‐Rh2 reduces AGEs/ROS and inflammatory signaling, reprogramming dendritic cells
Mengzhen Zhao, Zhibin Zhou, Yuxuan Wei, Xiangfan Huang, Zhiyong Zhou, Jiaheng Chen, Haoxin Cheng, Xiaotian Hu, Xiaolei Wang   +8 more
wiley   +1 more source

Peripheral Neuropathy in Metabolic Stress. [PDF]

Int J Mol Sci
Fu K, Yang J, Cao Y.
europepmc   +1 more source

Calcium-Dependent Cytoskeletal Collapse and Recovery of Axons After Partial Laser Ablation. [PDF]

J Neurochem
Mishra A, Joshi P, Ashraf MA, Pullarkat P.   +3 more
europepmc   +1 more source

Introducing Borsantrazole: A Trifunctional Boron‐Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice

Advanced Science, EarlyView.
Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Nitesh Sanghai, Rhonda Kelley, Ying Lao, M. Immanuel Reyes Madlangsakay, Prasanta Paul, M. Alejandra Llanes‐Cuesta, Jun‐Feng Wang, René P. Zahedi, Jiming Kong, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Painful neuromas exhibit axonal phenotypic shift via nociceptive and mechanosensitive marker up-regulation. [PDF]

PNAS Nexus
Tereshenko V, Raasveld FV, Hwang CD, Hussey MR, Johnston B, Valerio IL, Austen WG, Wainger BJ, Renthal W, Eberlin KR.   +9 more
europepmc   +1 more source

Label‐Free Myelin Fingerprinting: An Adult Human Post‐Mortem Brain Slice Platform via Coherent Anti‐Stokes Raman Spectroscopy

Advanced Science, EarlyView.
A serum‐free, air–liquid interface organotypic slice culture model preserves human post‐mortem corpus callosum tissue, successfully recovering from slicing trauma to reflect the donor's underlying disease state. Pairing label‐free Coherent anti‐Stokes Raman scattering (CARS) microscopy with k‐means clustering enables objective, high‐resolution ...
Kasra Roya‐Kouchaki, Jeroen P. Korterik, Femke Tjebbes, Geert J. Schenk, Herman L. Offerhaus, Antonio Luchicchi   +5 more
wiley   +1 more source