Results 221 to 230 of about 30,406 (272)

Designed Biomaterial‐Enhanced Cell Transplantation for Neural Tissue Engineering

Aggregate, EarlyView.
Biomaterials offer a promising solution for cell transplantation in the central nervous system by creating a protective environment that enhances cell survival, integration, and functional recovery in preclinical models of neurological disorders. ABSTRACT Cell transplantation therapy in the central nervous system is hindered by limited survival and ...
Yun Tang, Alice Le Friec, Menglin Chen, Di Sun   +3 more
wiley   +1 more source

The pH Dependency of Relative Ion Permeabilities in the Crayfish Giant Axon

, 1969
Alfred Strickholm, B. Gunnar Wallin, Peter Shrager   +2 more
openalex   +1 more source

3D Rotary Wet‐Spinning (RoWS) Biofabrication Directly Affects Proteomic Signature and Myogenic Maturation in Muscle Pericyte–Derived Human Myo‐Substitute

Aggregate, EarlyView.
Here we present a high‐resolution mass spectrometry‐based proteomics study, unravelling the molecular signatures evoked on human skeletal muscle‐derived pericytes after 3D rotary wet‐spinning (RoWS) biofabrication deposition. The presented work characterises for the very first time the molecular routes that are activated/inhibited in the 2D or 3D ...
Alessio Reggio, Claudia Fuoco, Francesca De Paolis, Rebecca Deodati, Stefano Testa, Nehar Celikkin, Marina Volpi, Sergio Bernardini, Ersilia Fornetti, Jacopo Baldi, Roberto Biagini, Dror Seliktar, Carmine Cirillo, Wojciech Swieszkowski, Paolo Grumati, Stefano Cannata, Marco Costantini, Cesare Gargioli   +17 more
wiley   +1 more source

Expanding the Tyrosine Kinase Domain of CSF1R? A Case Report From an Adult‐Onset Leukoencephalopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Adult‐onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP), also termed hereditary diffuse leukoencephalopathy with spheroids‐1 (HDLS1), results from mutations in the CSF1R gene and leads to progressive leukoencephalopathy.
Piervito Lopriore, Gianmichele Migaleddu, Pei‐Chien Tsai, Antonella Fogli, Maria Adelaide Caligo, Gabriele Siciliano, Mirco Cosottini, Yi‐Chung Lee, Yi‐Chu Liao, Michelangelo Mancuso, Roberto Ceravolo, Daniela Frosini   +11 more
wiley   +1 more source

Sodium and Potassium Ion Effluxes from Squid Axons under Voltage Clamp Conditions

, 1962
L. J. Mullins, William J. Adelman, R. A. Sjodin   +2 more
openalex   +1 more source

The tau isoform 1N4R confers vulnerability of MAPT knockout human iPSC‐derived neurons to amyloid beta and phosphorylated tau‐induced neuronal dysfunction

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION Human tau protein, composed of six brain‐specific isoforms, is a major driver of Alzheimer's disease (AD). The role of its isoforms however remains unclear and human AD models are scarce. METHODS We generated human MAPT– (tau–) knockout (KO) induced pluripotent stem cells (iPSC) using CRISPR/Cas9, differentiated these into ...
Sarah Buchholz, Mohamed Aghyad Al Kabbani, Michael Bell‐Simons, Lena Kluge, Cagla Cagmak, Jennifer Klimek, Natja Haag, Lukas C. Iohan, Audrey Coulon, Marcos R. Costa, Devrim Kilinc, Hans Zempel   +11 more
wiley   +1 more source

An Approach to the Physical Basis of Negative Conductance in the Squid Axon

, 1969
D. Agin
openalex   +1 more source

Effects of Qingyangshen glycosides on neuroplasticity in a mouse model of social defeat

Animal Models and Experimental Medicine, EarlyView.
Summary of the experimental effects of qingyangshen glycosides on neuroplasticity in mice model of social defeat. Abstract Background Qingyangshen (Cynanchum otophyllum C.K. Schneid) is a folk drug for treating depression and other mental disorders induced by social defeat stress.
Jingru Wang, Weishi Chen, Qiang Zhu, Yao Liu, Zheng Kang, Dingding Liu, Guirong Zeng   +6 more
wiley   +1 more source

Exploring the co‐morbid relationship between Alzheimer's disease and lung cancer in the 5xFAD transgenic mouse model

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of inverse comorbidities of Alzheimer's disease and lung cancer. Abstract Background Alzheimer's disease (AD) and lung cancer are leading causes of mortality among the older population. Epidemiological evidence suggests an antagonistic relationship between them, whereby patients with AD exhibit a reduced risk of developing cancer and ...
Mingfeng Li, Xinghan Wu, Lin Jiang, Min Liu, Gong Yanju, Xiaomeng Li, Fan Tian, Fan Ye, Jinlong Wang, Siyuan Wang, Chuan Qin, Ling Zhang   +11 more
wiley   +1 more source

Effect of in vivo reprogramming of astrocytes combined with exercise training on neurorepair in rats with spinal cord injury

Animal Models and Experimental Medicine, EarlyView.
Exercise and astrocyte reprogramming synergize to enhance motor function and reduce glial scarring after spinal cord injury, with combined therapies surpassing individual effects. Abstract Background The inability of damaged neurons to regenerate and of axons to establish new functional connections leads to permanent functional deficits after spinal ...
Zuliyaer Talifu, Xin Xu, Huayong Du, Zehui Li, Xiaoxin Wang, Chunjia Zhang, Yunzhu Pan, Han Ke, Wubo Liu, Feng Gao, Degang Yang, Yingli Jing, Yan Yu, Liangjie Du, Jianjun Li   +14 more
wiley   +1 more source