Results 241 to 250 of about 228,091 (312)

AAV-delivered TurboRFP enables streamlined tracing and analysis of corticospinal tract sprouting. [PDF]

Cell Rep Methods
Hernaiz-Llorens M, Londoño CJ, Wang E, Cai F, Saikia JM, Chavez-Martinez CL, Kim HJ, Agba CK, Zheng B.   +8 more
europepmc   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

H4K12 Lactylation Regulates NDUFS7 to Drive Microglia Reverse Electron Transport in Spinal Cord Injury

Advanced Science, EarlyView.
Lactate accumulation after SCI promotes H4K12la lactylation, which upregulates NDUFS7, triggering mitochondrial RET and ROS, enforcing pro‐inflammatory microglial polarization. MM@mPTC, a biomimetic nanotherapeutic, degrades LDHA in activated microglia, reducing H4K12la lactylation and blocking RET, thus curbing ROS, fostering a reparative phenotype ...
Chenglong Hong, Zhichen Jiang, Zhouwei Wu, Chenyu Wu, Jiang Liu, Kaijie Guo, Yihui Liang, Shaobo Xu, Yuchen Jin, Yong Xiao, Lei Guo, Hui Xu, Sunren Sheng, Chenggui Wang   +13 more
wiley   +1 more source

Reply to Panfoli et al.: From O₂ consumption in myelin to gap junctional ATP delivery in axons: An energy link needing further scrutiny. [PDF]

Proc Natl Acad Sci U S A
Witschas K, Ghysels A, Leybaert L.
europepmc   +1 more source

The Cytoplasmic MicroRNA‐Production Complex Regulates MicroRNA Sorting to Extracellular Vesicles During Synaptogenesis

Advanced Science, EarlyView.
The mechanisms of microRNA cargo sorting to extracellular vesicles, important mediators of cell communication, are not fully understood. This study reveals that the microRNA‐production machinery acts as a ‘hub’ for the sorting of microRNAs to extracellular vesicles, a process regulated by dynamic organelle interactions.
Yuzhou Zeng, Selina Luhmann, Aditi Saha, Marta Orlando, Haider Sami, Timo Glatter, Anna Antoniou   +6 more
wiley   +1 more source

Neurofilament Light Chain (Nfl) Level in Serum as a Suitable In Vivo Biomaker for Axonal Damage in a Murine Viral Model of Multiple Sclerosis. [PDF]

J Cell Mol Med
Segna A, Wannemacher R, Rohn K, Sippel V, Steiner MA, Lühder F, Flügel A, Baumgärtner W, Hülskötter K.   +8 more
europepmc   +1 more source

Pathology of general proprioception in a canine disease model of amyotrophic lateral sclerosis. [PDF]

J Neurol Sci
Morgan-Jack BR, Katz ML, Kick GR, Johnson GC, Delgado K, Makinen M, Coates JR.   +6 more
europepmc   +1 more source

Olfactory Ensheathing Cell Transplantation Combined With Electrical Epidural Stimulation as a Long-Term Treatment for Severe Spinal Cord Injury in Female Fischer 344 Rats. [PDF]

Eur J Neurosci
Ingraham Dixie KL, Tierno AM, Thornton MA, Mekonnen MA, Dale EA, Zhong H, Edgerton VR, Phelps PE.   +7 more
europepmc   +1 more source

Neocortical pyramidal cells with axon-carrying basal dendrites: a prominent feature regulated by activity. [PDF]

Brain Struct Funct
Bietz D, Ceylan B, Räk A, Köhler I, Wahle P.   +4 more
europepmc   +1 more source