Results 321 to 330 of about 448,604 (375)

Mislocalization of KCNQ2 Channels as a Pathogenic Mechanism in KCNQ2 Developmental and Epileptic Encephalopathy. [PDF]

J Neurosci
Springer K, Soh H, Paz Zavala R, Varghese N, Lutz C, Zuberi AR, Jackson AC, Tzingounis AV.   +7 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

KHSRP-mediated decay of axonally localized prenyl-Cdc42 mRNA slows nerve regeneration. [PDF]

PLoS Genet
Zdradzinski MD, Vaughn LS, Matoo S, Trumbull K, Smith TP, Noblitt D, Buchanan CN, Loomis A, Thames E, Lee SJ, Perrone-Bizzozero N, Lu Q, Larsen JM, Twiss JL.   +13 more
europepmc   +1 more source

A Blood‐Brain Barrier‐Penetrant Ag(III) Corrole Compound Rescues Alzheimer's Disease Pathology by Targeting Aβ42‐Induced Oxidative Stress

Advanced Science, EarlyView.
The newly designed metallo‐corrole (Mor‐Cor)Ag(III) with a morpholino group exhibited promising therapeutic potential for Alzheimer's disease. It significantly reduces reactive oxygen species (ROS), decreases GFAP expression, increases neurite length, and decreases cell death compared to other similar metallo‐corroles. Abstract Alzheimer's disease (AD)
Arup Tarai, Tuhina Mitra, Tanmoy Pain, Jyotiprakash Mallick, Rwiddhi Chakraborty, Kallam Tejaswi, Swagata Ghatak, Sanjib Kar   +7 more
wiley   +1 more source

Acute Intermittent Hypoxia Exerts Beneficial Effects and Promotes Repair in Male Mice in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. [PDF]

Glia
Tokarska N, Roberts J, Koralage SR, Naniong JMA, Johnston JM, Wei Z, Verge VMK.   +6 more
europepmc   +1 more source

Endoplasmic reticulum in the axon: Insights into structural dynamics and implications in neurodegeneration

Thuy D.T. Vu, Hyun Sung
openalex   +1 more source

Targeting and anchoring the mechanosensitive ion channel Piezo to facilitate its inhibition of axon regeneration. [PDF]

PLoS Genet
Wang Q, Miles L, Wang S, Ryll LM, Noristani HN, Schauer E, Monahan Vargas EJ, Powell J, O'Rourke-Ibach SJ, Akizu N, Wildonger J, Li S, Song Y.   +12 more
europepmc   +1 more source

Microstructure.jl: A Julia package for probabilistic microstructure model fitting with diffusion MRI. [PDF]

Imaging Neurosci (Camb)
Gong T, Yendiki A.
europepmc   +1 more source