Results 331 to 340 of about 436,100 (389)

A Study of Skeletal Stem Cell Dynamics and Its Potential Applications in the Design of a Titanium Implant for Senile Osteoporosis

Advanced Science, EarlyView.
Senescent mesenchymal stromal cells (MSCs) drive age‐related osteoporosis (A‐OP) via adipogenic bias. Resveratrol, selected from transcriptome‐identified core genes, is delivered locally using GelMA‐chitosan hydrogel‐functionalised titanium implants. In A‐OP microenvironments, the hydrogel enables the sustained release of resveratrol, which reverses ...
Wuzhe Fan, Tao Zheng, Mingsong Mao, Pengfei Gao, Yulu Yang, Rong Wang, Yao Yang, Yangpeng Zuo, Tiantian Yuan, Ruqing Bai, Weihu Yang, Xingchen Yan, Kaiyong Cai   +12 more
wiley   +1 more source

Single intracerebroventricular TNFR2 agonist injection impacts remyelination in the cuprizone model. [PDF]

J Mol Med (Berl)
Pegoretti V, Boerema A, Kats K, Dafauce Garcia JM, Fischer R, Kontermann RE, Pfizenmaier K, Laman JD, Eisel ULM, Baron W.   +9 more
europepmc   +1 more source

Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

Advanced Science, EarlyView.
The study reveals that astrocytic ET‐1 system is solely activated by thrombin following SCI via RhoA/NF‐κB and MAPKs/NF‐κB signal pathway. The release of astrocytic ET‐1 drives microglia polarization toward M1 phenotype through YAP signaling via ETA and ETB receptors.
Bingqiang He, Si Xu, Mengdi Li, Hui Li, Shaolan Li, Li Niu, Honghua Song, Rixin Cai, Yue Zhou, Zhilong Cao, Yingjie Wang, Yongjun Wang   +11 more
wiley   +1 more source

Investigation of early axonal phenotypes in an iPSC-derived ALS cellular model using a microfluidic device. [PDF]

Front Cell Neurosci
Otomo A, Nishijima K, Murakami Y, Ishikawa M, Yudahira H, Shimakura K, Okano H, Aoki M, Kimura H, Hadano S.   +9 more
europepmc   +1 more source

Early embryogenesis in CHDFIDD mouse model reveals facial clefts and altered cranial neurogenesis

Disease Models & Mechanisms
Marek Hampl, Nela Jandová, Denisa Lusková, Monika Nováková, Tereza Szotkowská, Štěpán Čada, Jan Procházka, Jiri Kohoutek, Marcela Buchtová   +8 more
doaj   +1 more source

Bioactive Silk Sericin/Bioceramic Nerve Guidance Conduit for Effective Repair of Long‐Gap Transected Peripheral Nerve Injury through Regulating Schwann Cells

Advanced Science, EarlyView.
This study identifies akermanite among six bioceramics and reveals its ability to enhance Schwann cell's proliferation, migration, and secretion. When combined with silk sericin, the composite conduit synergistically enhances Schwann cell‐mediated regenerative processes.
Qiangfei Su, Jian Wang, Yu Song, Zhaowenbin Zhang, Bo Cai, Xiakeerzhati Xiaohalati, Jingwei Liu, Haozhe Li, Zheng Wang, Jiang Chang, Lin Wang   +10 more
wiley   +1 more source

Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nerves. [PDF]

iScience
Dingwall CB, Sasaki Y, Strickland A, Wu T, Summers DW, Bloom AJ, DiAntonio A, Milbrandt J.   +7 more
europepmc   +1 more source

Bioprinted Organoids: An Innovative Engine in Biomedicine

Advanced Science, EarlyView.
Bioprinted organoids refer to either the printing of stem cells into tissue shape and subsequent differentiate into organoids, or assembling induced organoids as bioinks to replicate native organ. It enables the creation of miniaturized organs with complex architectures and physiological functions, potentially enhancing reproducibility, throughput, and
Zhengwei Li, Kai Li, Cheng Zhang, Yingying Zhao, Yiyuan Guo, Jia He, Shiyuan Chang, Xinyi Fang, Kaizheng Liu, Pingping Zhu, Zhenzhen Chen, Changshun Ruan   +11 more
wiley   +1 more source

Transcranial Optogenetic Stimulation Promotes Corticospinal Tract Axon Regeneration to Repair Spinal Cord Injury by Activating the JAK2/STAT3 Pathway. [PDF]

Neurospine
Ma YH, Chen HY, Wei QS, Peng LZ, Zhang KJ, Deng QW, Wang LJ, Liu Z, Lai BQ, Ding Y, Li G, Jiang B, Lan Y, Zeng X, Zeng YS.   +14 more
europepmc   +1 more source

Morphometric analysis of peripheral nerves in people with spinal cord injury. [PDF]

Sci Rep
Messina A, Galea MP.
europepmc   +1 more source