Results 341 to 350 of about 431,675 (382)
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Axonal transport of lipid in goldfish optic axons
Neurochemical Research, 1978After injection of labeled glycerol, choline, or serine into the eye of goldfish, labeled lipids were axonally transported along the optic nerve to the optic tectum. Although the different precursors were presumably incorporated into somewhat different lipid populations, all three were approximately equally effective in labeling the lipids transported ...
Bernice Grafstein +3 more
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Degeneration and regeneration of axons in the lesioned spinal cord.
Physiological Reviews, 1996For many decades, the inability of lesioned central neurons to regrow was accepted almost as a "law of nature", and on the clinical level, spinal cord and brain lesions were seen as being irreversible.
M. Schwab, D. Bartholdi
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Abnormalities of the axonal cytoskeleton in giant axonal neuropathy
Journal of Neurocytology, 1988Intermediate filaments accumulate abnormally in a variety of cell types in individuals with human inherited giant axonal neuropathy (GAN). A characteristic feature of this disorder is the occurrence of focal axonal enlargements filled with accumulations of neurofilaments.
P. K. Thomas +3 more
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Persistence of Axonal Transport in Isolated Axons of the Mouse
European Journal of Neuroscience, 1993AbstractWe have examined the hypothesis, for the case of mouse axons, that isolating an axon from its cell body will lead to a rapid failure of fast axonal transport as anterogradely moving organelles vacate the axon in a proximo‐distal direction, and retrogradely moving organelles vacate it in the opposite direction.
Mark A. Bisby, R. S. Smith
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Experimental Neurology, 2001
Injury to axons in the CNS leads to little regenerative repair and loss of function. Conversely, injury to axons in the PNS results in vigorous regrowth of severed axons, usually with restoration of function. This difference is generally attributed to a CNS environment that either cannot support or actively inhibits regeneration and/or a failure of CNS
Farid A.K.M. Ahmed +2 more
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Injury to axons in the CNS leads to little regenerative repair and loss of function. Conversely, injury to axons in the PNS results in vigorous regrowth of severed axons, usually with restoration of function. This difference is generally attributed to a CNS environment that either cannot support or actively inhibits regeneration and/or a failure of CNS
Farid A.K.M. Ahmed +2 more
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Biological Reviews, 1996
Axons damaged in a peripheral nerve are often able to regenerate from the site of injury along the degenerate distal segment of the nerve to reform functional synapses. Schwann cells play a central role in this process. However, in the adult mammalian central nervous system, from which Schwann cells are absent, axonal regeneration does not progress to ...
J E, Brecknell, J W, Fawcett
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Axons damaged in a peripheral nerve are often able to regenerate from the site of injury along the degenerate distal segment of the nerve to reform functional synapses. Schwann cells play a central role in this process. However, in the adult mammalian central nervous system, from which Schwann cells are absent, axonal regeneration does not progress to ...
J E, Brecknell, J W, Fawcett
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Axonal oscillations in developing mammalian nerve axons
Physical Review E, 2005We study neuronal spike propagation in a developing myelinated axon in various stages of its development through detailed computational modeling. Recently, a form of bursting (axonal bursting), has been reported in axons in developing nerves in the absence of potassium channels.
Peter Jung, Shangyou Zeng
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Axon-to-axon transmission in tullidora (buckthorn) neuropathy
Experimental Neurology, 1984Oral administration of ether extracts of the tullidora ( Karwinskia humboldtiana ) fruit, which contains an identified neurotoxin, produced flaccid hind limb paralysis in cats after a latency of 4 to 7 weeks. Acute experiments were conducted after the paralysis was evident. Spinal roots of lumbar and sacral segments were transected as close as possible
Arturo Hernández-Cruz +1 more
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Science Signaling, 2023
Demyelination by microglia reduces the likelihood of axonal degeneration in a model of cytotoxic T cell–driven myelin perturbation.
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Demyelination by microglia reduces the likelihood of axonal degeneration in a model of cytotoxic T cell–driven myelin perturbation.
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Axonal degeneration and disorders of the axonal cytoskeleton
1995Abstract This chapter discusses cytoskeletal changes in axonal degeneration. It begins with a review of the organization of the normal axonal cytoskeleton, followed by a summary of the current understanding of Wallerian degeneration. It then considers the slowly evolving axonal degenerations in which alterations in neurofilament content ...
Edwin B. George +3 more
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