Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton. [PDF]
PLoS ONE, 2012 Axon injury and degeneration is a common consequence of diverse neurological conditions including multiple sclerosis, traumatic brain injury and spinal cord injury. The molecular events underlying axon degeneration are poorly understood.
Patrick Garland +6 more
doaj +7 more sources
Axonal maintenance, glia, exosomes, and heat shock proteins [version 1; referees: 3 approved] [PDF]
F1000Research, 2016 Of all cellular specializations, the axon is especially distinctive because it is a narrow cylinder of specialized cytoplasm called axoplasm with a length that may be orders of magnitude greater than the diameter of the cell body from which it originates.
Michael Tytell +2 more
doaj +4 more sources
Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport [PDF]
Cells, 2023 The amyloid precursor protein (APP) is a key molecular component of Alzheimer’s disease (AD) pathogenesis. Proteolytic APP processing generates various cleavage products, including extracellular amyloid beta (Aβ) and the cytoplasmic APP intracellular ...
Svenja König +11 more
doaj +2 more sources
Purification of mouse axoplasmic proteins from dorsal root ganglia nerves for proteomics analysis [PDF]
STAR Protocols, 2022 Summary: The study of neuronal signaling ex vivo requires the identification of the proteins that are represented within the neuronal axoplasm. Here, we describe a detailed protocol to isolate the axoplasm of peripheral and central axonal branches of ...
Guiping Kong +4 more
doaj +2 more sources
Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. [PDF]
PLoS ONE, 2013 Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefined ...
Gerardo A Morfini +19 more
doaj +8 more sources
ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation [PDF]
Scientific Reports, 2017 Mutations in Fused in Sarcoma/Translocated in Liposarcoma (FUS) cause familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive axonal degeneration mainly affecting motor neurons.
Reddy Ranjith K. Sama +11 more
doaj +3 more sources
On mathematical modeling of the propagation of a wave ensemble within an individual axon [PDF]
Frontiers in Cellular Neuroscience, 2023 The long history of studying the propagation of an action potential has revealed that an electrical signal is accompanied by mechanical and thermal effects. All these effects together generate an ensemble of waves. The consistent models of such a complex
Tanel Peets +3 more
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Resistivity of axoplasm. I. Resistivity of extruded squid axoplasm. [PDF]
The Journal of general physiology, 1975 Six methods have given squid axoplasm resistivities of from 1.0 to 6.9 times seawater (X SW), so another was tried. A 100-mum platinized electrode was to be inserted from each end of an axion in iso-osmotic sucrose and impedance between them measured vs. separation.
Kenneth S. Cole
openalex +4 more sources
Mitochondria delay action potential propagation [PDF]
Communications BiologyThe internal resistance of axons to ionic current flow determines action potential conduction velocity. Although mitochondria support axonal function, axons have been modeled as organelle-free cables, and mitochondrial impact on conduction velocity ...
Ann M. Castelfranco, Pepe Alcami
doaj +2 more sources
The Amyloid Precursor Protein of Alzheimer's Disease Clusters at the Organelle/Microtubule Interface on Organelles that Bind Microtubules in an ATP Dependent Manner. [PDF]
PLoS ONE, 2016 The amyloid precursor protein (APP) is a causal agent in the pathogenesis of Alzheimer's disease and is a transmembrane protein that associates with membrane-limited organelles.
James W Stevenson +6 more
doaj +5 more sources