Results 1 to 10 of about 7,418 (226)

Soluble axoplasm enriched from injured CNS axons reveals the early modulation of the actin cytoskeleton. [PDF]

PLoS ONE, 2012
Axon injury and degeneration is a common consequence of diverse neurological conditions including multiple sclerosis, traumatic brain injury and spinal cord injury. The molecular events underlying axon degeneration are poorly understood.
Patrick Garland, Lucy J Broom, Shmma Quraishe, Paul D Dalton, Paul Skipp, Tracey A Newman, V Hugh Perry   +6 more
doaj   +7 more sources

Axon-Autonomous Effects of the Amyloid Precursor Protein Intracellular Domain (AICD) on Kinase Signaling and Fast Axonal Transport [PDF]

Cells, 2023
The amyloid precursor protein (APP) is a key molecular component of Alzheimer’s disease (AD) pathogenesis. Proteolytic APP processing generates various cleavage products, including extracellular amyloid beta (Aβ) and the cytoplasmic APP intracellular ...
Svenja König, Nadine Schmidt, Karin Bechberger, Sarah Morris, Mercedes Priego, Hannah Zaky, Yuyu Song, Jan Pielage, Silke Brunholz, Scott T. Brady, Stefan Kins, Gerardo Morfini   +11 more
doaj   +2 more sources

Inhibition of fast axonal transport by pathogenic SOD1 involves activation of p38 MAP kinase. [PDF]

PLoS ONE, 2013
Dying-back degeneration of motor neuron axons represents an established feature of familial amyotrophic lateral sclerosis (FALS) associated with superoxide dismutase 1 (SOD1) mutations, but axon-autonomous effects of pathogenic SOD1 remained undefined ...
Gerardo A Morfini, Daryl A Bosco, Hannah Brown, Rodolfo Gatto, Agnieszka Kaminska, Yuyu Song, Linda Molla, Lisa Baker, M Natalia Marangoni, Sarah Berth, Ehsan Tavassoli, Carolina Bagnato, Ashutosh Tiwari, Lawrence J Hayward, Gustavo F Pigino, D Martin Watterson, Chun-Fang Huang, Gary Banker, Robert H Brown, Scott T Brady   +19 more
doaj   +8 more sources

Purification of mouse axoplasmic proteins from dorsal root ganglia nerves for proteomics analysis [PDF]

STAR Protocols, 2022
Summary: The study of neuronal signaling ex vivo requires the identification of the proteins that are represented within the neuronal axoplasm. Here, we describe a detailed protocol to isolate the axoplasm of peripheral and central axonal branches of ...
Guiping Kong, Luming Zhou, Anja Freiwald, Kirill Shkura, Simone Di Giovanni   +4 more
doaj   +2 more sources

On mathematical modeling of the propagation of a wave ensemble within an individual axon [PDF]

Frontiers in Cellular Neuroscience, 2023
The long history of studying the propagation of an action potential has revealed that an electrical signal is accompanied by mechanical and thermal effects. All these effects together generate an ensemble of waves. The consistent models of such a complex
Tanel Peets, Kert Tamm, Jüri Engelbrecht, Jüri Engelbrecht   +3 more
doaj   +2 more sources

Resistivity of axoplasm. I. Resistivity of extruded squid axoplasm. [PDF]

The Journal of general physiology, 1975
Six methods have given squid axoplasm resistivities of from 1.0 to 6.9 times seawater (X SW), so another was tried. A 100-mum platinized electrode was to be inserted from each end of an axion in iso-osmotic sucrose and impedance between them measured vs. separation.
Kenneth S. Cole
openalex   +5 more sources

Properties Live Axoplasm [PDF]

Single Cell Biology, 2015
The purpose of fundamental science, in my opinion, consists not only in making new discoveries about the natural world and life but also to explain the potential mechanisms of the processes that we describe. What is particularly stimulating is scientific work in which the scientist manages to discover and provide proof of something unbelievable, that ...

openalex   +2 more sources

Axoplasm isolation from peripheral nerve [PDF]

Developmental Neurobiology, 2009
AbstractLocalized changes in the composition of axonal cytoplasm (axoplasm) are critical for many biological processes, including axon guidance, responses to injury, neurite outgrowth, and axon‐glia interactions. Biochemical and molecular studies of these mechanisms have been heavily focused on in vitro systems because of the difficulty of obtaining ...
Ida Rishal, Izhak Michaelevski, Meir Rozenbaum, Vera Shinder, Katalin F. Medzihradszky, Alma L. Burlingame, Mike Fainzilber   +6 more
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Uptake and release of 45Ca by Myxicola axoplasm. [PDF]

The Journal of general physiology, 1981
The binding and release of 45Ca by axoplasm isolated from Myxicola giant axons were examined. Two distinct components of binding were observed, one requiring ATP and one not requiring ATP. The ATP-dependent binding was largely prevented by the addition of mitochondrial inhibitors, whereas the ATP-independent component was unaffected by these inhibitors.
R. F. Abercrombie, Leona M. Masukawa, R. A. Sjodin, D. R. Livengood   +3 more
openalex   +5 more sources

On mechanisms of electromechanophysiological interactions between the components of signals in axons [PDF]

Proceedings of the Estonian Academy of Sciences, 2020
Recent studies have revealed the complex structure of nerve signals in axons. There is experimental evidence that the propagation of an electrical signal (action potential) is accompanied by mechanical and thermal effects.
Jüri Engelbrecht, Kert Tamm, Tanel Peets   +2 more
doaj   +1 more source