Axoplasm Isolation from Rat Sciatic Nerve [PDF]
Journal of Visualized Experiments, 2010 Isolation of pure axonal cytoplasm (axoplasm) from peripheral nerve is crucial for biochemical studies of many biological processes. In this article, we demonstrate and describe a protocol for axoplasm isolation from adult rat sciatic nerve based on the following steps: (1) dissection of nerve fascicles and separation of connective tissue; (2 ...
Ida Rishal +2 more
openalex +4 more sources
Distinct small non-coding RNA landscape in the axons and released extracellular vesicles of developing primary cortical neurons and the axoplasm of adult nerves. [PDF]
RNA Biol, 2021 Mesquita-Ribeiro R +8 more
europepmc +4 more sources
Interrelationship Between Intraepithelial Nerve Endings and Epithelial Cells in the Rat Epiglottis Revealed by Array Tomography With Scanning Electron Microscopy. [PDF]
J Comp NeurolTwo types of intraepithelial nerve endings were observed in the epiglottis, i.e., thin nerve fibers/endings with varicosities and terminal swelling and ramified nerve ending consisted of a branched parent axon and large terminal parts. Both nerve endings were closely attached with epithelial cells.
Yamamoto Y +4 more
europepmc +2 more sources
On mechanisms of electromechanophysiological interactions between the components of signals in axons; pp. 81–96 [PDF]
Proceedings of the Estonian Academy of Sciences, 2020 Recent studies have revealed the complex structure of nerve signals in axons. There is experimental evidence that the propagation of an electrical signal (action potential) is accompanied by mechanical and thermal effects.
Jüri Engelbrecht +2 more
doaj +1 more source
Brain Sciences, 2021 The objective of this pioneering study was to assess potentially neuroprotective properties of topiramate (TPM), a broad spectrum and newer-generation antiepileptic used against damage to synaptic endings of the temporal lobe neocortex in experimental ...
Piotr Sobaniec +3 more
doaj +1 more source
Acta Chimica Slovenica, 2021 Local anesthetics are one of the most widely used drug classes in clinical practice. Like many other biological molecules, their properties are altered depending on their protonation status, which is dependent on the pH of the environment. We studied the
Hana Kavčič +4 more
doaj +1 more source
Synaptic actions of amyotrophic-lateral-sclerosis-associated G85R-SOD1 in the squid giant synapse [PDF]
, 2020 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Song, Y.
Song, Yuyu
core +1 more source
Nuclear Alpha-Synuclein in Parkinson's Disease and the Malignant Transformation in Melanoma. [PDF]
Neurol Res IntBackground: Alpha‐synuclein (ASyn), a marker of Parkinson’s disease (PD) and other neurodegenerative processes, plays pivotal roles in neuronal nuclei and synapses. ASyn and its phosphorylated form at Serine 129 (p‐ASyn) are involved in DNA protection and repair, processes altered in aging, neurodegeneration, and cancer.
Jimenez-Capdeville ME +5 more
europepmc +2 more sources
The Dying Forward Hypothesis of ALS: Tracing Its History
Brain Sciences, 2021 The site of origin of amyotrophic lateral sclerosis (ALS), although unsettled, is increasingly recognized as being cortico-fugal, which is a dying-forward process primarily starting in the corticomotoneuronal system.
Andrew Eisen
doaj +1 more source
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2. [PDF]
PLoS ONE, 2017 Prion diseases include a number of progressive neuropathies involving conformational changes in cellular prion protein (PrPc) that may be fatal sporadic, familial or infectious.
Emiliano Zamponi +13 more
doaj +1 more source