Axonal maintenance, glia, exosomes, and heat shock proteins [version 1; referees: 3 approved] [PDF]
F1000Research, 2016 Of all cellular specializations, the axon is especially distinctive because it is a narrow cylinder of specialized cytoplasm called axoplasm with a length that may be orders of magnitude greater than the diameter of the cell body from which it originates.
Michael Tytell +2 more
doaj +4 more sources
The Amyloid Precursor Protein of Alzheimer's Disease Clusters at the Organelle/Microtubule Interface on Organelles that Bind Microtubules in an ATP Dependent Manner. [PDF]
PLoS ONE, 2016 The amyloid precursor protein (APP) is a causal agent in the pathogenesis of Alzheimer's disease and is a transmembrane protein that associates with membrane-limited organelles.
James W Stevenson +6 more
doaj +5 more sources
ALS-linked FUS exerts a gain of toxic function involving aberrant p38 MAPK activation [PDF]
Scientific Reports, 2017 Mutations in Fused in Sarcoma/Translocated in Liposarcoma (FUS) cause familial forms of amyotrophic lateral sclerosis (ALS), a neurodegenerative disease characterized by progressive axonal degeneration mainly affecting motor neurons.
Reddy Ranjith K. Sama +11 more
doaj +3 more sources
Nuclear Alpha-Synuclein in Parkinson's Disease and the Malignant Transformation in Melanoma. [PDF]
Neurol Res IntBackground: Alpha‐synuclein (ASyn), a marker of Parkinson’s disease (PD) and other neurodegenerative processes, plays pivotal roles in neuronal nuclei and synapses. ASyn and its phosphorylated form at Serine 129 (p‐ASyn) are involved in DNA protection and repair, processes altered in aging, neurodegeneration, and cancer.
Jimenez-Capdeville ME +5 more
europepmc +2 more sources
Effectiveness of Shacklock's Neural Mobilization for Acute and Sub-Acute Lumbar Disc Prolapsed: A Randomized Controlled Trial. [PDF]
Health Sci RepABSTRACT Background and Aims Lumbar disc prolapse (LDP) is a more severe health issue worldwide. Shacklock's neural mobilization is a useful technique for treating prolapsed discs. The study aimed to examine the effectiveness of Shacklock's neural mobilization for acute and subacute LDP.
Nahid ZBS +8 more
europepmc +2 more sources
Brain Sciences, 2021 The objective of this pioneering study was to assess potentially neuroprotective properties of topiramate (TPM), a broad spectrum and newer-generation antiepileptic used against damage to synaptic endings of the temporal lobe neocortex in experimental ...
Piotr Sobaniec +3 more
doaj +1 more source
Acta Chimica Slovenica, 2021 Local anesthetics are one of the most widely used drug classes in clinical practice. Like many other biological molecules, their properties are altered depending on their protonation status, which is dependent on the pH of the environment. We studied the
Hana Kavčič +4 more
doaj +1 more source
Synaptic actions of amyotrophic-lateral-sclerosis-associated G85R-SOD1 in the squid giant synapse [PDF]
, 2020 © The Author(s), 2020. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Song, Y.
Song, Yuyu
core +1 more source
The Dying Forward Hypothesis of ALS: Tracing Its History
Brain Sciences, 2021 The site of origin of amyotrophic lateral sclerosis (ALS), although unsettled, is increasingly recognized as being cortico-fugal, which is a dying-forward process primarily starting in the corticomotoneuronal system.
Andrew Eisen
doaj +1 more source
Prion protein inhibits fast axonal transport through a mechanism involving casein kinase 2. [PDF]
PLoS ONE, 2017 Prion diseases include a number of progressive neuropathies involving conformational changes in cellular prion protein (PrPc) that may be fatal sporadic, familial or infectious.
Emiliano Zamponi +13 more
doaj +1 more source