Results 21 to 30 of about 7,418 (226)

Three‐dimensional architecture of the subepithelial corpuscular nerve ending in the rat epiglottis reconstructed by array tomography with scanning electron microscopy

Journal of Comparative Neurology, Volume 531, Issue 17, Page 1846-1866, December 2023., 2023
Laryngeal laminar nerve endings were reconstructed from serial ultrathin sections. Several terminal parts of the endings entered into the epithelial layer and attached to the basal epithelial cells, suggesting the interaction between epithelial cells. Secretory vesicles in the nerve endings may release glutamate to maintain continuous discharge during ...
Yoshio Yamamoto, Kuniaki Sasaki, Misaki Komuro, Takuya Yokoyama, Sayed Sharif Abdali, Nobuaki Nakamuta   +5 more
wiley   +1 more source

Review on electrically conductive smart nerve guide conduit for peripheral nerve regeneration

Journal of Biomedical Materials Research Part A, Volume 111, Issue 12, Page 1916-1950, December 2023., 2023
Electroactive smart nerve guide conduit for injured peripheral nerve regeneration Abstract At present, peripheral nerve injuries (PNIs) are one of the leading causes of substantial impairment around the globe. Complete recovery of nerve function after an injury is challenging.
Mustafijur Rahman, Tanvir Mahady Dip, Rajiv Padhye, Shadi Houshyar   +3 more
wiley   +1 more source

Mechanisms for the maintenance and eventual degradation of neurofilament proteins in the distal segments of severed goldfish Mauthner axons [PDF]

, 1996
Cellular mechanisms that might affect the degradation of neurofilament proteins (NFPs) were examined in the distal segments of severed goldfish Mauthner axons (M-axons), which do not degenerate for more than 2 months after severance.
Archer, Cullen, Bittner, George D., Nguyen, Tri, Raabe, Tim D.   +3 more
core   +1 more source

Increased activity of IRE1 improves the clinical presentation of EAE

The FASEB Journal, Volume 37, Issue 12, December 2023., 2023
Enhancing the physiological activation of IRE1α reduces the symptoms of experimental autoimmune encephalomyelitis (EAE) in mice. The IRE1α (C148S) mutant is characterized by increased and prolonged activation of IRE1α relative to the wild‐type IRE1α. Animals carrying this mutation exhibit improved clinical scores when challenged with EAE, presenting ...
Valerie Bracchi‐Ricard, Kayla Nguyen, Daniela Ricci, Brian Gaudette, Jorge Henao‐Mejia, Roberta Brambilla, Tetyana Martynyuk, Tali Gidalevitz, David Allman, John R. Bethea, Yair Argon   +10 more
wiley   +1 more source

Extent and mechanism of sealing in transected giant axons of squid and earthworms [PDF]

, 1994
Transected axons are often assumed to seal at their cut ends by the formation of continuous membrane barriers that allow for the restoration of function in the axonal stumps.
Ballinger, Martis L., Bittner, George D., Fishman, Harvey M., Krause, Todd L.   +3 more
core   +1 more source

α‐Synuclein induces deficiency in clathrin‐mediated endocytosis through inhibiting synaptojanin1 expression

Journal of Neurochemistry, Volume 167, Issue 3, Page 461-484, November 2023., 2023
α‐Synuclein (α‐syn) over‐expression defected clathrin‐mediated endocytosis (CME) via down‐regulating synaptojanin1 (SYNJ1) and related protein expression. SYNJ1 is the key protein in alleviating disrupted synaptic function caused by α‐syn through interfering with vesicle recycling.
Dong‐Yan Song, Lin Yuan, Na Cui, Cong Feng, Lanxia Meng, Xin‐He Wang, Man Xiang, Di Liu, Chun Wang, Zhentao Zhang, Jia‐Yi Li, Wen Li   +11 more
wiley   +1 more source

Reduced axonal diameter of peripheral nerve fibres in a mouse model of Rett syndrome [PDF]

, 2017
Rett syndrome (RTT) is a neurological disorder characterized by motor and cognitive impairment, autonomic dysfunction and a loss of purposeful hand skills.
Bahey, Noha G., Bailey, Mark E.S., Cobb, Stuart R., Edgar, Julia M., Gadalla, Kamal K.E., McGonigal, Rhona   +5 more
core   +1 more source

Alleviating early demyelination in ischaemia/reperfusion by inhibiting sphingosine‐1‐phosphate receptor 2 could protect visual function from impairment

Brain Pathology, Volume 33, Issue 5, September 2023., 2023
In this study, we observed that demyelination is an important pathological change in retinal I/R injury and investigated that S1PR2‐specific inhibitor JTE‐013 could alleviate the demyelination, optic neuropathy, and visual impairment caused by retinal I/R injury.
Jingfei Xue, Jicheng Lin, Zhe Liu, Qi Zhang, Jiahui Tang, Jiaxu Han, Siting Wu, Canying Liu, Ling Zhao, Yiqing Li, Yehong Zhuo   +10 more
wiley   +1 more source

Human organ donor-derived vagus nerve biopsies allow for well-preserved ultrastructure and high-resolution mapping of myelinated and unmyelinated fibers

Scientific Reports, 2021
The vagus nerve provides motor, sensory, and autonomic innervation of multiple organs, and electrical vagus nerve stimulation (VNS) provides an adjunctive treatment option for e.g. medication-refractory epilepsy and treatment-resistant depression.
Leif A. Havton, Natalia P. Biscola, Esther Stern, Plamen V. Mihaylov, Chandrashekhar A. Kubal, John M. Wo, Anita Gupta, Elizabeth Baronowsky, Matthew P. Ward, Deborah M. Jaffey, Terry L. Powley   +10 more
doaj   +1 more source

Defined Tau Phosphospecies Differentially Inhibit Fast Axonal Transport Through Activation of Two Independent Signaling Pathways

Frontiers in Molecular Neuroscience, 2021
Tau protein is subject to phosphorylation by multiple kinases at more than 80 different sites. Some of these sites are associated with tau pathology and neurodegeneration, but other sites are modified in normal tau as well as in pathological tau ...
Sarah L. Morris, Sarah L. Morris, Ming-Ying Tsai, Sarah Aloe, Karin Bechberger, Svenja König, Gerardo Morfini, Gerardo Morfini, Scott T. Brady, Scott T. Brady   +9 more
doaj   +1 more source