Results 31 to 40 of about 7,370 (219)
Regulation of Axonal Transport by Protein Kinases [PDF]
, 2015 The intracellular transport of organelles, proteins, lipids, and RNA along the axon is essential for neuronal function and survival. This process, called axonal transport, is mediated by two classes of ATP-dependent motors, kinesins, and cytoplasmic ...
Gibbs, KL, Greensmith, L, Schiavo, G
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Folia Morphologica, 2022 BACKGROUND: The sciatic nerve is a peripheral nerve and is more vulnerable to compression with subsequent short- or long-term neuronal dysfunction. The current study was designed to elucidate the possible ameliorative effect of L-carnitine and sildenafil
O. I. Zedan, M. A. Bashandy
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Increased expression of matrix metalloproteinase-9 in patients with temporal lobe epilepsy [PDF]
, 2014 Aim: The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited.
Acar, Feridun +3 more
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Folia Neuropathologica, 2019 The present study aimed at exploring a potentially neuroprotective effect of topiramate (TPM), one of the most commonly used newer-generation, broad-spectrum, antiepileptic drugs against ultrastructural damage of hippocampal synaptic endings in the ...
Joanna Łotowska +5 more
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Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. [PDF]
, 2010 Many mutations confer one or more toxic function(s) on copper/zinc superoxide dismutase 1 (SOD1) that impair motor neuron viability and cause familial amyotrophic lateral sclerosis (FALS).
A Durazo +64 more
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Regulation of retinal axon growth by secreted Vax1 homeodomain protein
eLife, 2014 Retinal ganglion cell (RGC) axons of binocular animals cross the midline at the optic chiasm (OC) to grow toward their synaptic targets in the contralateral brain. Ventral anterior homeobox 1 (Vax1) plays an essential role in the development of the OC by
Namsuk Kim +9 more
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Modelling selective activation of small myelinated nerve fibres using a monopolar point electrode [PDF]
, 1995 The aim of this study is to investigate theoretically the possibility for activation of small myelinated nerve fibres without activating larger ones when stimulating a nerve fibre bundle using a monopolar point electrode.
Debruyne, F.M.J. +4 more
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Glutamatergic Reinnervation and Assembly of Glutamatergic Synapses in Adult Rat Skeletal Muscle Occurs at Cholinergic Endplates [PDF]
, 2009 After denervation of adult rat abdominal muscles, the postsynaptic apparatus of neuromuscular junctions (NMJs) retains its original architecture and clustering of acetylcholine receptors (AChRs).
A. BARBON +14 more
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Slow axoplasmic transport under scrutiny [PDF]
Biological Research, 2011 The origin of axoplasmic proteins is central for the biology of axons. For over fifty years axons have been considered unable to synthesize proteins and that cell bodies supply them with proteins by a slow transport mechanism. To allow for prolonged transport times, proteins were assumed to be stable, i.e., not degraded in axons. These are now textbook
Court, Felipe A, Álvarez, Jaime
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Mitochondrial Transport and Turnover in the Pathogenesis of Amyotrophic Lateral Sclerosis
Biology, 2019 Neurons are high-energy consuming cells, heavily dependent on mitochondria for ATP generation and calcium buffering. These mitochondrial functions are particularly critical at specific cellular sites, where ionic currents impose a large energetic burden,
Veronica Granatiero, Giovanni Manfredi
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