Results 51 to 60 of about 7,370 (219)

Alterations in Sub-Axonal Architecture Between Normal Aging and Parkinson’s Diseased Human Brains Using Label-Free Cryogenic X-ray Nanotomography

Frontiers in Neuroscience, 2020
Gaining insight to pathologically relevant processes in continuous volumes of unstained brain tissue is important for a better understanding of neurological diseases.
Hung Tri Tran, Esther H. R. Tsai, Amanda J. Lewis, Tim Moors, J. G. J. M. Bol, Iman Rostami, Ana Diaz, Allert J. Jonker, Manuel Guizar-Sicairos, Joerg Raabe, Henning Stahlberg, Wilma D. J. van de Berg, Mirko Holler, Sarah H. Shahmoradian   +13 more
doaj   +1 more source

A High‐Fidelity RNA‐Targeting Cas13X Downregulates Connexin43 in Macroglia: A Novel Neuroprotective Strategy for Glaucoma

Advanced Science, Volume 12, Issue 33, September 4, 2025.
This study highlights the role of connexin43 (Cx43) in mediating glia activation and neuroinflammation in glaucoma. Using Cx43 knockout mice, it is shown that macroglial cells‐derived Cx43 modulates microglial activation, proliferation, migration, and polarization.
Guoli Zhao, Zhen Li, Ming‐Jie Zhao, Shu‐Ying Li, Qing Xia, Shuoyu Xu, Yu Zhang, Yi Wang, Fang Li, Yu‐Ling Liu, Yun‐Hui Guo, Ruo‐Xi Xu, Han Zhou, Hong Zhou, Wen‐Wen Ding, Yong‐Chen Wang, Yanying Miao, Zhongfeng Wang   +17 more
wiley   +1 more source

Investigating the role of SARM1 in central nervous system

Ibrain, Volume 11, Issue 3, Page 297-305, Fall 2025.
Sterile‐α and Toll/interleukin 1 receptor (TIR) motif‐containing protein 1 (SARM1) is a pivotal molecule that has garnered extensive attention in neuroscience. As an intracellular molecule, SARM1 possesses various crucial biological functions in the nervous system.
Junjie Wang, Yuhang Shi, Jinglei Tian, Liming Tang, Fang Cao   +4 more
wiley   +1 more source

Neurophysiology [PDF]

, 1958
Contains reports on four research projects.Bell Telephone Laboratories, IncorporatedThe Teagle Foundation, IncorporatedNational Science ...
Duchane, E. M., Gesteland, R. C., Johnson, A. R., Lettvin, Jerome Y., McCulloch, Warren S., Pitts, Walter H., Wall, P. D.   +6 more
core   +2 more sources

The Extremely Low Mechanical Force Generated by Nano‐Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons

Small, Volume 21, Issue 38, September 25, 2025.
Nano‐pulling induces stabilization, reorganization, and reorientation of the microtubule network. The nucleus of stretched cells experiences increased lateral tension, becomes more spherical, and develops surface grooves. At the level of gene expression regulation, changes in nuclear morphology induce global chromatin remodeling, leading to reduced ...
Alessandro Falconieri, Lorenzo Da Palmata, Valentina Cappello, Tiziana Julia Nadjeschda Schmidt, Pietro Folino, Barbara Storti, Ranieri Bizzarri, Vittoria Raffa   +7 more
wiley   +1 more source

Late observation of the neuroprotective effect of citicoline in uveitis: an impact on the ultrastructure of the choriocapillaris, retina and optic nerve in rabbits

Journal of Ophthalmology
Purpose: To evaluate the ultrastructure of the choriocapillaris, retina and optic nerve (ON) in citicoline-treated versus non-treated rabbits at the late time point after inducing non-infectious anterior and intermediate uveitis.
V. Ulianov, I. Horianova, N. Molchaniuk
doaj   +1 more source

The unusual microtubule polarity in teleost retinal pigment epithelial cells. [PDF]

, 1988
In cells of the teleost retinal pigment epithelium (RPE), melanin granules disperse into the RPE cells long apical projections in response to light onset, and aggregate toward the base of the RPE cell in response to dark onset.
BURNSIDE, Beth, Troutt, L
core   +1 more source

A Mathematical Model for Neuron Reorientation and Axonal Growth on a Cyclically Stretched Substrate

Studies in Applied Mathematics, Volume 155, Issue 3, September 2025.
ABSTRACT Experiments have shown that mechanical cues play a central role in determining the direction and rate of axonal growth. In particular, neurons seeded on planar substrates undergoing periodic stretching have been shown to reorient and reach a stable equilibrium orientation corresponding to angles within the interval 60∘,90∘$\left[60^{\circ },90^
Annachiara Colombi, Andrea Battaglia, Chiara Giverso   +2 more
wiley   +1 more source

Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features

Biology of Sex Differences, 2018
Background Disruption of axonal transport plays a pivotal role in diabetic neuropathy. A sex-dimorphism exists in the incidence and symptomatology of diabetic neuropathy; however, no studies so far have addressed sex differences in axonal motor proteins ...
Marzia Pesaresi, Silvia Giatti, Roberto Spezzano, Simone Romano, Silvia Diviccaro, Tiziana Borsello, Nico Mitro, Donatella Caruso, Luis Miguel Garcia-Segura, Roberto Cosimo Melcangi   +9 more
doaj   +1 more source

Spatiotemporal microRNA profile in peripheral nerve regeneration: miR-138 targets vimentin and inhibits Schwann cell migration and proliferation

Neural Regeneration Research, 2018
While the peripheral nervous system has regenerative ability, restoration of sufficient function remains a challenge. Vimentin has been shown to be localized in axonal growth fronts and associated with nerve regeneration, including myelination ...
Travis B Sullivan, Litchfield C Robert, Patrick A Teebagy, Shannon E Morgan, Evan W Beatty, Bryan J Cicuto, Peter K Nowd, Kimberly M Rieger-Christ, David J Bryan   +8 more
doaj   +1 more source