Results 51 to 60 of about 7,418 (226)

AXOPLASMIC TRANSPORT IN THE CRAYFISH NERVE CORD [PDF]

Proceedings of the National Academy of Sciences, 1969
Axoplasmic proteins in the crayfish nerve cord were labeled by the incorporation of high specific activity 3 H-leucine that was injected into one of the abdominal ganglia. The labeled proteins moved caudad as a sharply defined peak at 1.1 mm/day.
H. L. Fernandez, P. F. Davison
openaire   +3 more sources

The Extremely Low Mechanical Force Generated by Nano‐Pulling Induces Global Changes in the Microtubule Network, Nuclear Morphology, and Chromatin Transcription in Neurons

Small, EarlyView.
Nano‐pulling induces stabilization, reorganization, and reorientation of the microtubule network. The nucleus of stretched cells experiences increased lateral tension, becomes more spherical, and develops surface grooves. At the level of gene expression regulation, changes in nuclear morphology induce global chromatin remodeling, leading to reduced ...
Alessandro Falconieri, Lorenzo Da Palmata, Valentina Cappello, Tiziana Julia Nadjeschda Schmidt, Pietro Folino, Barbara Storti, Ranieri Bizzarri, Vittoria Raffa   +7 more
wiley   +1 more source

Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition [PDF]

, 2016
© The Author(s), 2016. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Neurobiology of Aging 47 (2016): 113–126, doi:10.1016/j.neurobiolaging.2016.07.015.Misfolded tau ...
Abdelmesih, Brenda, Brady, Scott T., Combs, Benjamin, Cox, Kristine, Kanaan, Nicholas M., Morfini, Gerardo A.   +5 more
core   +1 more source

The evolution of muscle spindles

Experimental Physiology, EarlyView.
Abstract Muscle spindles are stretch‐sensitive mechanoreceptors found in the skeletal muscles of most four‐limbed vertebrates. They are unique amongst sensory receptors in the ability to regulate their sensitivity by contraction of the intrafusal muscle fibres on which the sensory endings lie.
Robert W. Banks, Uwe Proske
wiley   +1 more source

Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features

Biology of Sex Differences, 2018
Background Disruption of axonal transport plays a pivotal role in diabetic neuropathy. A sex-dimorphism exists in the incidence and symptomatology of diabetic neuropathy; however, no studies so far have addressed sex differences in axonal motor proteins ...
Marzia Pesaresi, Silvia Giatti, Roberto Spezzano, Simone Romano, Silvia Diviccaro, Tiziana Borsello, Nico Mitro, Donatella Caruso, Luis Miguel Garcia-Segura, Roberto Cosimo Melcangi   +9 more
doaj   +1 more source

Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport [PDF]

, 2016
In Alzheimer's disease (AD), tau undergoes numerous modifications, including increased phosphorylation at serine-422 (pS422). In the human brain, pS422 tau protein is found in prodromal AD, correlates well with cognitive decline and neuropil thread ...
Brady, Scott T., Combs, Benjamin, Counts, Scott E., Cox, Kristine, Kanaan, Nicholas M., Morfini, Gerardo, Tiernan, Chelsea T.   +6 more
core   +1 more source

A Facile Strategy to Restore the Optic Nerve Functionality Using an Injectable Conducting Hydrogel

Advanced Science, Volume 12, Issue 21, June 5, 2025.
An injectable conductive polymer hydrogel from poly (3,4‐ethylenedioxythiophene) (PEDOT) is developed to facilitate the recovery of electrophysiological function in injured optic nerve. The hydrogel can be injected directly at the injury site and spontaneously gel in place.
Changchun Yu, Yandi Zhou, Shuang Yao, Ziyi Wang, Sihao Ye, Rubing Qi, Hai Hu, Keke Liu, Yabo Wu, Tom Lawson, Lu Yan, Yong Liu, Wencan Wu   +12 more
wiley   +1 more source

Glutamatergic Reinnervation and Assembly of Glutamatergic Synapses in Adult Rat Skeletal Muscle Occurs at Cholinergic Endplates [PDF]

, 2009
After denervation of adult rat abdominal muscles, the postsynaptic apparatus of neuromuscular junctions (NMJs) retains its original architecture and clustering of acetylcholine receptors (AChRs).
A. BARBON, BAIGUERA C, BARLATI S, BORONI F, BRUNELLI G, BUFFELLI M, CAMBIANICA I, CLEMENTI F, ETTORRE M, FRANCOLINI M, GUARNERI B, LA VIA L, LANZILLOTTA A, PIZZI M, SPANO PF   +14 more
core   +1 more source

A computational model coupling mechanics and electrophysiology in spinal cord injury [PDF]

, 2014
Traumatic brain injury and spinal cord injury have recently been put under the spotlight as major causes of death and disability in the developed world.
García Grajales, Julián Andrés, Jérusalem, Antoine, Merchan Perez, Angel, Peña Sanchez, Jose Maria   +3 more
core   +2 more sources

Stabilization of mitochondria‐associated endoplasmic reticulum membranes regulates Aβ generation in a three‐dimensional neural model of Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract INTRODUCTION We previously demonstrated that regulating mitochondria‐associated endoplasmic reticulum (ER) membranes (MAMs) affects axonal Aβ generation in a well‐characterized three‐dimensional (3D) neural Alzheimer's disease (AD) model. MAMs vary in thickness and length, impacting their functions.
Jacob C. Zellmer, Marina B. Tarantino, Michelle Kim, Selene Lomoio, Masato Maesako, György Hajnóczky, Raja Bhattacharyya   +6 more
wiley   +1 more source