Results 41 to 50 of about 6,214 (208)

Endothelin‐Converting Enzyme‐Like 1 Regulated by LIF Contributes to Chronic Constriction Injury‐Induced Neuropathic Pain in Mice

CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.
After chronic constriction injury (CCI), leukemia inhibitory factor (LIF) is transported from the distal injury site to dorsal root ganglion (DRG) neurons and promotes the expression of ECEL1, thereby promoting sympathetic sprouting and causing neuropathic pain. ABSTRACT Aims This study is to investigate the role of Endothelin‐converting enzyme‐like 1 (
Feng Gao, Yuchen Pan, Yong Huang, Chen Gu, Xiaowei Song, Cunjin Wang   +5 more
wiley   +1 more source

Vesicular glutamate release from central axons contributes to myelin damage [PDF]

, 2018
Neuronal activity can lead to vesicular release of glutamate. Here the authors demonstrate that vesicular release of glutamate occurs in axons during ischemic conditions, and that an allosteric modulator of GluN2C/D is protective in models of ischemic ...
A Chamorro, A Momiyama, AJ Mierzwa, AM Arranz, AS Saab, C Akazawa, C Iadecola, CA Mosley, CN Wang, DJ Rossi, E Romanelli, EG Sozmen, G Gido, H Bading, H Monyer, H Yanamoto, I Lundgaard, I Micu, I Micu, I Micu, J Guo, J Moring, JB Bederson, JJ Alix, JJ Naleway, KB Hansen, KM Mohan, L Pantoni, L Zhang, M Kukley, MG Salter, N Lozovaya, NB Hamilton, PC Christensen, PH Chan, R Karadottir, R Macrez, RD Fields, RF Fern, RR Sturrock, S Baltan, S Li, S Spitzer, SC Harney, SG Brickley, Y Wang   +45 more
core   +3 more sources

Curcumin Promotes the Recovery of Motor Function After Brachial Plexus Avulsion Injury in Rats

Brain and Behavior, Volume 15, Issue 8, August 2025.
CUR promotes the recovery of motor function in rats after BPRA by inhibiting inflammation, promoting axonal remyelination, and reducing muscle atrophy, laying a foundation for the treatment of BPRA with CUR. ABSTRACT Background and Purpose Brachial plexus root avulsion (BPRA) often results in the loss of upper limb motor function.
Sijing Li, Bing He, Guijuan Zhou, Lin Wu, Xuanwei Wen, Limin Deng, Shudong Lin, Guozhi Liu, Shuangxi Chen, Zijian Xiao   +9 more
wiley   +1 more source

Localization of axonally transported 125I-wheat germ agglutinin beneath the plasma membrane of chick retinal ganglion cells. [PDF]

, 1983
The distribution of 125I-wheat germ agglutinin (WGA) transported by axons of chick retinal ganglion cells to layer d of the optic tectum was studied by electron microscopic autoradiography.
LaVail, JH, McDonald, DM, Sugino, IK
core  

Correlation of Structure With Function: Future Utilities for Optical Coherence Tomography Angiography in Neuro‐Ophthalmology

Clinical &Experimental Ophthalmology, Volume 53, Issue 6, Page 682-697, August 2025.
ABSTRACT Optical coherence tomography angiography is a burgeoning imaging modality in Ophthalmology. In this review, we outline the breadth of potential utility for optical coherence tomography angiography for diagnosis and prognostication in neuro‐ophthalmology.
Marzieh Tahmasebi Sarvestani, Sudha Cugati, Celia Chen   +2 more
wiley   +1 more source

Pathogenesis of amyotrophic lateral sclerosis [PDF]

, 2016
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) or motor neuron disease is a rapidly progressive neurodegenerative disorder. The primary involvement is of motor neurons in the brain, spinal cord and peripherally. There is secondary weakness of muscles
Morgan, S, Orrell, RW
core   +1 more source

Sustained Enlargement in Vagus and Sural Nerve Cross‐Sectional Areas in Fibromyalgia: A Longitudinal Study

Journal of Neuroimaging, Volume 35, Issue 3, May/June 2025.
ABSTRACT Background and Purpose Fibromyalgia (FM) is a complex condition with unclear pathophysiology. While central sensitization is commonly accepted as the predominant cause of pain symptoms, numerous evidences suggest a role for the peripheral nervous system, particularly small fiber neuropathy.
Benedetta Bianchi, Edoardo Cipolletta, Sonia Farah, Fausto Salaffi, Marco Di Carlo   +4 more
wiley   +1 more source

The unusual microtubule polarity in teleost retinal pigment epithelial cells. [PDF]

, 1988
In cells of the teleost retinal pigment epithelium (RPE), melanin granules disperse into the RPE cells long apical projections in response to light onset, and aggregate toward the base of the RPE cell in response to dark onset.
BURNSIDE, Beth, Troutt, L
core   +1 more source

Imaging of the Lamina Cribrosa using Swept-Source Optical Coherence Tomography. [PDF]

, 2012
The lamina cribrosa (LC) is the presumed site of axonal injury in glaucoma. Its deformation has been suggested to contribute to optic neuropathy by impeding axoplasmic flow within the optic nerve fibers, leading to apoptosis of retinal ganglion cells. To
Mansouri, Kaweh, N Weinreb, Robert, Nuyen, Brenda   +2 more
core   +2 more sources

Quantitative MRI Assessment Using Variable Echo Time Imaging of Peripheral Nerve Injury in ATTRv Amyloidosis Patients

European Journal of Neurology, Volume 32, Issue 4, April 2025.
ABSTRACT Background and Purpose Early detection of peripheral nerve damage in patients with hereditary transthyretin amyloidosis (ATTRv) has become essential for the prompt initiation of effective, recently approved therapies. In our study, we propose a new variable echo time (vTE) MRI sequence as a non‐invasive method to detect nerve injury in ATTRv ...
Carlo Asteggiano, Matteo Paoletti, Elisa Vegezzi, Xeni Deligianni, Francesco Santini, Niels Bergsland, Nico Papinutto, Massimiliano Todisco, Giuseppe Cosentino, Andrea Cortese, Laura Obici, Giovanni Palladini, Anna Pichiecchio   +12 more
wiley   +1 more source