Results 51 to 60 of about 6,214 (208)

Longitudinal Imaging Biomarkers Correlate with Progressive Motor Deficit in the Mouse Model of Charlevoix‐Saguenay Ataxia

Annals of Neurology, Volume 97, Issue 3, Page 425-434, March 2025.
Objective In autosomal recessive spastic ataxia of Charlevoix‐Saguenay (ARSACS) disease, severity and age of onset vary greatly, hindering to objectively measure and predict clinical progression. Thickening of the retinal nerve fiber layer is distinctive of ARSACS patients, as assessed by optical coherence tomography, whereas conventional brain ...
Valentina Gigliucci, Su‐Chun Huang, Giorgio Boschetti, Alessandra Scaravilli, Valerio Castoldi, Paola Podini, Angelo Quattrini, Sirio Cocozza, Letizia Leocani, Francesca Maltecca   +9 more
wiley   +1 more source

Diffuse axonal injury and oxidative stress: A comprehensive review [PDF]

, 2017
Traumatic brain injury (TBI) is one of the worldâ\u80\u99s leading causes of morbidity and mortality among young individuals. TBI applies powerful rotational and translational forces to the brain parenchyma, which results in a traumatic diffuse axonal ...
Cerretani, Daniela, Fiaschi, Anna Ida, Fineschi, Vittorio, Fraschetti, Flavia, Frati, Alessandro, Frati, Paola, Gatto, Vittorio, La Russa, Raffaele, Pesce, Alessandro, Pinchi, Enrica, Santurro, Alessandro   +10 more
core   +4 more sources

Stabilization of mitochondria‐associated endoplasmic reticulum membranes regulates Aβ generation in a three‐dimensional neural model of Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 2, February 2025.
Abstract INTRODUCTION We previously demonstrated that regulating mitochondria‐associated endoplasmic reticulum (ER) membranes (MAMs) affects axonal Aβ generation in a well‐characterized three‐dimensional (3D) neural Alzheimer's disease (AD) model. MAMs vary in thickness and length, impacting their functions.
Jacob C. Zellmer, Marina B. Tarantino, Michelle Kim, Selene Lomoio, Masato Maesako, György Hajnóczky, Raja Bhattacharyya   +6 more
wiley   +1 more source

The autonomous axon: a model based on local synthesis of proteins

Biological Research, 2001
In the current understanding of axons, axoplasmic synthesis of proteins is negated, and it is asserted that proteins are transported from perikarya to axons. This 'transport model' in which axons are fully dependent of perikarya is seriously flawed. The '
JAIME ALVAREZ
doaj  

Self‐Healing COCu‐Tac Hydrogel Enhances iNSCs Transplantation for Spinal Cord Injury by Promoting Mitophagy via the FKBP52/AKT Pathway

Advanced Science, Volume 12, Issue 3, January 20, 2025.
A novel hydrogel‐based transplant system (COCu‐Tac) for induced neural stem cell (iNSCs) therapy in spinal cord injury is introduced. This system offers self‐healing properties, sustained tacrolimus release, and reduces immune rejection without systemic immunosuppression.
Zhenming Tian, Han‐Jian Hu, Chun Cheung Chan, Tian Hu, Chaoyang Cai, Hong Li, Limin Rong, Gang‐Biao Jiang, Bin Liu   +8 more
wiley   +1 more source

Dendritic transport. I. Colchicine stimulates the transport of lysosomal enzymes from cell bodies to dendrites. [PDF]

, 1985
Injection of colchicine into the lateral cerebral ventricle of the rat was found to induce a paradoxical translocation of two lysosomal enzymes, dipeptidyl peptidase II (Dpp II) and acid phosphatase, from the soma of neurons to the dendrites. Following a
Bundman, MC, Gorenstein, C, Lew, PJ, Olds, JL, Ribak, CE   +4 more
core   +1 more source

Exploring Glaucoma: From Pathogenesis to Emerging Diagnostic and Management Strategies

Journal of Ophthalmology, Volume 2025, Issue 1, 2025.
Glaucoma is a leading cause of irreversible blindness globally, affecting millions of individuals. It encompasses a group of progressive optic neuropathies characterized by retinal ganglion cell loss and visual field deterioration, often associated with elevated intraocular pressure.
Rajesh Kumar Goit, Nilufer Yesilirmak
wiley   +1 more source

The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus [PDF]

, 2010
Expansion of a polyglutamine (polyQ) tract in the Huntingtin (Htt) protein causes Huntington's disease (HD), a fatal inherited neurodegenerative disorder.
Baquet, Bates, Bennett, Bhakar, Blahos, Caviston, Chen, Cho, Colin, Colomer, Dragatsis, Dunkley, Edoardo Marcora, Engelender, Fagerlund, Fridmacher, Gauthier, Graham, Gray, Gutekunst, Hanz, Harkiolaki, Hayden, Hering, Hickey, Hunt, Imarisio, Jordan, Joshi, Kaltschmidt, Kaltschmidt, Kaltschmidt, Kennedy, Korkin, Kornau, Leavitt, Leavitt, Li, Li, Li, Lipsky, Ma, Marcora, Marini, Marini, Mary B. Kennedy, Mattson, Meffert, Meffert, Menalled, Mikenberg, Mosammaparast, Otis, Patterson, Perlson, Shimojo, Simmons, Song, Strand, Sun, Suzuki, Takano, The Huntington's Disease Collaborative Research Group, Thompson, Tian, Towbin, Trushina, Velier, Wang, Wellmann, Xie, Zhang, Zuccato, Zuccato, Zuccato   +74 more
core   +4 more sources

Corneal Biomechanical Changes Induced by Chronic Elevated Intraocular Pressure: Implications for Glaucoma Pathogenesis and Management

Journal of Ophthalmology, Volume 2025, Issue 1, 2025.
The significance and contributions of corneal biomechanics in the study of chronic elevated intraocular pressure are multifaceted. Not only does it enhance our understanding of how chronic elevated intraocular pressure affects corneal structure and function, but it also offers new perspectives for the early diagnosis of glaucoma. Analysis of the cornea’
Mengzhen Xie, Zhiyong Huang, Ke Ma, Yingping Deng, Jing Tang, Shweta Negi   +5 more
wiley   +1 more source

AXOPLASMIC TRANSPORT IN THE CRAYFISH NERVE CORD [PDF]

Proceedings of the National Academy of Sciences, 1969
Axoplasmic proteins in the crayfish nerve cord were labeled by the incorporation of high specific activity 3 H-leucine that was injected into one of the abdominal ganglia. The labeled proteins moved caudad as a sharply defined peak at 1.1 mm/day.
H L, Fernandez, P F, Davison
openaire   +2 more sources