Results 51 to 60 of about 2,127,716 (198)

Association of APOE genotype and cerebrospinal fluid Aβ and tau biomarkers with cognitive and motor phenotype in amyotrophic lateral sclerosis

open access: yesEuropean Journal of Neurology, Volume 31, Issue 9, September 2024.
Abstract Objective Little is known about amyotrophic lateral sclerosis (ALS)‐nonspecific cognitive deficits – most notably memory disturbance – and their biological underpinnings. We investigated the associations of the Alzheimer's disease (AD) genetic risk factor APOE and cerebrospinal fluid (CSF) biomarkers Aβ and tau proteins with cognitive and ...
Alessio Maranzano   +22 more
wiley   +1 more source

Cdk5 inhibition in the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis suppresses neurodegeneration and extends survival

open access: yesJournal of Neurochemistry, Volume 168, Issue 9, Page 2908-2925, September 2024.
Some postmortem studies on patients with amyotrophic lateral sclerosis (ALS) disclosed tau pathology in the central nervous system. Since deregulated cyclin‐dependent kinase 5 (Cdk5) activity is closely correlated with tau pathology, Cdk5 inhibition in the ALS mouse model was performed in this study. Intrathecal injection of AAV9‐Cdk5‐shRNA in SOD1G93A
Ahwon Kim   +2 more
wiley   +1 more source

LncRNA H19 knockdown promotes neuropathologic and functional recovery via the Nrf2/HO‐1 axis after traumatic brain injury

open access: yesCNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
Knockdown of the lncRNA H19 significantly promotes recovery from traumatic brain injury (TBI) in mice, as evidenced by reduced neuroinflammation, attenuated tissue damage including gray and white matter, and improved neurological function. This neuroprotective effect was significantly mediated by activation of the Nrf2/HO‐1 signaling pathway, revealing
Qiankang Chen   +10 more
wiley   +1 more source

Sortilin‐Mediated Inhibition of TREK1/2 Channels in Primary Sensory Neurons Promotes Prediabetic Neuropathic Pain

open access: yesAdvanced Science, Volume 11, Issue 23, June 19, 2024.
This study identifies the roles of TREK1 and TREK2 in prediabetic neuropathic pain and investigates the modulation of Sortilin within these channels. It suggests that Sortilin overexpression leads to a decrease in TREK1 and TREK2 expression, which in turn contributes to the modulation of neural hyperexcitability and nociceptive hypersensitivity in rats
Wei Sun   +8 more
wiley   +1 more source

The role of autophagy in odontogenesis, dental implant surgery, periapical and periodontal diseases

open access: yesJournal of Cellular and Molecular Medicine, Volume 28, Issue 8, April 2024.
Abstract Autophagy is a cellular process that is evolutionarily conserved, involving the sequestration of damaged organelles and proteins into autophagic vesicles, which subsequently fuse with lysosomes for degradation. Autophagy controls the development of many diseases by influencing apoptosis, inflammation, the immune response and different cellular
Sevinç İnan, Emre Barış
wiley   +1 more source

Research Progress of Nerve Mobilization in Basic and Clinical Rehabilitation

open access: yes康复学报, 2019
The purpose of this paper is to provide a systematic review of the literature concerning the theoretical basis, research advance and clinical status of nerve mobilization(NM)in various neuro-musculoskeletal conditions, which may provide important ...
Shuo LUAN   +4 more
doaj  

Vibration‐induced disruption of retrograde axoplasmic transport in peripheral nerve [PDF]

open access: bronze, 2005
Ji‐Geng Yan   +4 more
openalex   +1 more source

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