Results 61 to 70 of about 6,214 (208)

Factors Associated with Lamina Cribrosa Displacement After Trabeculectomy Measured by Optical Coherence Tomography in Advanced Primary Open Angle Glaucoma [PDF]

, 2018
Purpose: To investigate the relationship of lamina cribrosa displacement to corneal biomechanical properties and visual function after mitomycin C-augmented trabeculectomy.
Doozandeh, Azadeh, Efatizadeh, Ali, Esfandiari, Hamed, Loewen, Nils A., Yaseri, Mehdi   +4 more
core   +1 more source

Loss of Smek1 Induces Tauopathy and Triggers Neurodegeneration by Regulating Microtubule Stability

Advanced Science, Volume 11, Issue 40, October 28, 2024.
Impairment in microtubule stability and mitochondria transportation is a common pathway in neurodegeneration. The present study elucidates a mechanism by which Smek1 protects against tauopathy by binding to Kif2a in neurons and thereby regulates tau phosphorylation. Smek1 deficiency leads to declined motor and cognition function in mice. Together, they
Ruo‐Nan Duan, Ai Liu, Yue‐Qing Sun, Yun‐Fang Xie, Shi‐Jun Wei, Shang Gao, Yi‐Ming Liu, Xi Li, Wen‐Jie Sun, Jiang‐Xia Li, Chuan‐Zhu Yan, Qi‐Ji Liu   +11 more
wiley   +1 more source

Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells [PDF]

, 2018
Canine respiratory coronavirus (CRCoV), identified in 2003, is a member of the Coronaviridae family. The virus is a betacoronavirus and a close relative of human coronavirus OC43 and bovine coronavirus.
A Milewska, A Pratelli, A Quan, Aleksandra Milewska, AM Zaki, Artur Szczepanski, B Hernaez, B Jancekova, BA Mainou, BJ Dille, C Burkard, C Kooi, C Liu, C Liu, D Dutta, DM Blau, E Dietzel, E Girard, E Hamme Van, EJ Bowman, F Samson, G Preta, GA Wudiri, GM Li, GR Ares, H Imhoff, H Lin, H Wang, IC Huang, IM Mackay, J Li, J Schindelin, J Somsel Rodman, JA Mitchell, JK Millet, JL Wang, JP Lim, JR Henley, Judy A. Mitchell, K Erles, K Erles, K Owczarek, K Shirato, K Shirato, Katarzyna Owczarek, Krzysztof Pyrc, KS Choi, L Kleist von, L Pelkmans, LH Wang, LJ Reed, M Marsh, MG Hemida, MJ Geisow, MJ Vincent, O Achour, O Heikkila, P Duckert, P Eifart, P Oh, Q Xu, R Nomura, S Bertram, S Bolte, S Gierer, S Matsuyama, SL Priestnall, TA Hill, VC Chu, X Ren, Y Inoue, Y Phonphok, Z Qian, Z Qinfen, Zbigniew Baster, Zenon Rajfur   +75 more
core   +8 more sources

Association of APOE genotype and cerebrospinal fluid Aβ and tau biomarkers with cognitive and motor phenotype in amyotrophic lateral sclerosis

European Journal of Neurology, Volume 31, Issue 9, September 2024.
Abstract Objective Little is known about amyotrophic lateral sclerosis (ALS)‐nonspecific cognitive deficits – most notably memory disturbance – and their biological underpinnings. We investigated the associations of the Alzheimer's disease (AD) genetic risk factor APOE and cerebrospinal fluid (CSF) biomarkers Aβ and tau proteins with cognitive and ...
Alessio Maranzano, Federico Verde, Antonella Dubini, Silvia Torre, Eleonora Colombo, Alberto Doretti, Francesco Gentile, Arianna Manini, Ilaria Milone, Alberto Brusati, Silvia Peverelli, Serena Santangelo, Edoardo Gioele Spinelli, Erminio Torresani, Davide Gentilini, Stefano Messina, Claudia Morelli, Barbara Poletti, Federica Agosta, Antonia Ratti, Massimo Filippi, Vincenzo Silani, Nicola Ticozzi   +22 more
wiley   +1 more source

Cdk5 inhibition in the SOD1G93A transgenic mouse model of amyotrophic lateral sclerosis suppresses neurodegeneration and extends survival

Journal of Neurochemistry, Volume 168, Issue 9, Page 2908-2925, September 2024.
Some postmortem studies on patients with amyotrophic lateral sclerosis (ALS) disclosed tau pathology in the central nervous system. Since deregulated cyclin‐dependent kinase 5 (Cdk5) activity is closely correlated with tau pathology, Cdk5 inhibition in the ALS mouse model was performed in this study. Intrathecal injection of AAV9‐Cdk5‐shRNA in SOD1G93A
Ahwon Kim, Do‐Yeon Lee, Jung‐Joon Sung   +2 more
wiley   +1 more source

MSC-derived mitochondria promote axonal regeneration via Atf3 gene up-regulation by ROS induced DNA double strand breaks at transcription initiation region

Cell Communication and Signaling
Background The repair of peripheral nerve injury poses a clinical challenge, necessitating further investigation into novel therapeutic approaches. In recent years, bone marrow mesenchymal stromal cell (MSC)-derived mitochondrial transfer has emerged as ...
Yingchi Zhang, Tao Xu, Jie Xie, Hua Wu, Weihua Hu, Xuefeng Yuan   +5 more
doaj   +1 more source

Comparison of retinal nerve fiber layer thinning and retinal ganglion cell loss after optic nerve transection in adult albino rats [PDF]

, 2015
We compared the time-course and magnitude of retinal nerve fiber layer (RNFL) thinning with that of retinal ganglion cell (RGC) loss after intraorbital optic nerve transection (IONT) in adult ...
Agudo-Barriuso, M, Nadal-Nicolas, FM, Nieto-Lόpez, L, Nucci, C, Rovere, G, Sobrado-Calvo, P, Vidal-Sanz, M, Villegas-Perez, MP   +7 more
core   +1 more source

LncRNA H19 knockdown promotes neuropathologic and functional recovery via the Nrf2/HO‐1 axis after traumatic brain injury

CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
Knockdown of the lncRNA H19 significantly promotes recovery from traumatic brain injury (TBI) in mice, as evidenced by reduced neuroinflammation, attenuated tissue damage including gray and white matter, and improved neurological function. This neuroprotective effect was significantly mediated by activation of the Nrf2/HO‐1 signaling pathway, revealing
Qiankang Chen, Biwu Wu, Ziyu Shi, Yana Wang, Yiwen Yuan, Xingdong Chen, Yuqing Wang, Jin Hu, Leilei Mao, Yanqin Gao, Gang Wu   +10 more
wiley   +1 more source

Sortilin‐Mediated Inhibition of TREK1/2 Channels in Primary Sensory Neurons Promotes Prediabetic Neuropathic Pain

Advanced Science, Volume 11, Issue 23, June 19, 2024.
This study identifies the roles of TREK1 and TREK2 in prediabetic neuropathic pain and investigates the modulation of Sortilin within these channels. It suggests that Sortilin overexpression leads to a decrease in TREK1 and TREK2 expression, which in turn contributes to the modulation of neural hyperexcitability and nociceptive hypersensitivity in rats
Wei Sun, Fan Yang, Yan Wang, Yan Yang, Rui Du, Xiao‐Liang Wang, Zhi‐Xin Luo, Jun‐Jie Wu, Jun Chen   +8 more
wiley   +1 more source

The role of autophagy in odontogenesis, dental implant surgery, periapical and periodontal diseases

Journal of Cellular and Molecular Medicine, Volume 28, Issue 8, April 2024.
Abstract Autophagy is a cellular process that is evolutionarily conserved, involving the sequestration of damaged organelles and proteins into autophagic vesicles, which subsequently fuse with lysosomes for degradation. Autophagy controls the development of many diseases by influencing apoptosis, inflammation, the immune response and different cellular
Sevinç İnan, Emre Barış
wiley   +1 more source