Results 61 to 70 of about 13,775 (242)

Psychedelics Promote Structural and Functional Neural Plasticity. [PDF]

, 2018
Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the fast ...
Barragan, Eden V, Burbach, Kyle F, Cameron, Lindsay P, Dennis, Megan Y, Duim, Whitney C, Gray, John A, Greb, Alexandra C, Ly, Calvin, McAllister, A Kimberley, Olson, David E, Ori-McKenney, Kassandra M, Paddy, Michael R, Soltanzadeh Zarandi, Sina, Sood, Alexander, Wilson, Paige C, Wong, Jonathan M   +15 more
core   +2 more sources

The Australia story: Current status and future challenges for the clinical applications of psychedelics

British Journal of Pharmacology, EarlyView.
Abstract The past decade has seen a huge increase in clinical research with psychedelic drugs and 3,4‐methylenedioxymethamphetamine (MDMA), which have revealed great potential for treating mental health conditions. Given this progress in research, as well as the current unmet clinical need of millions of patients, in 2023, the Australian Therapeutic ...
David J Nutt, Peter Hunt, Anne Katrin Schlag, Paul Fitzgerald   +3 more
wiley   +1 more source

The ‘Edibility Approach’: Using Edibility to Explore Relationships, Plant Agency and the Porosity of Species’ Boundaries [PDF]

, 2017
This paper introduces the Edibility Approach, which proposes that the condi-tion of ‘being edible’ is a mechanism that some plants employ to influence their in-gesters to care for them.
Attala, Luci
core   +1 more source

Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial

Psychological Medicine, 2018
Background Recent open-label trials show that psychedelics, such as ayahuasca, hold promise as fast-onset antidepressants in treatment-resistant depression.
Fernanda Palhano-Fontes, Dayanna Barreto, H. Onias, K. Andrade, Morgana M. Novaes, J. Pessoa, S. Mota-Rolim, F. Osório, R. Sanches, R. G. dos Santos, L. F. Tófoli, Gabriela de Oliveira Silveira, M. Yonamine, J. Riba, F. Santos, Antonio A Silva-Junior, J. Alchieri, N. Galvão-Coelho, B. Lobão-Soares, J. Hallak, Emerson Arcoverde, J. P. Maia-de-Oliveira, D. Araujo   +22 more
semanticscholar   +1 more source

Psilocybin as a novel treatment for chronic pain

British Journal of Pharmacology, EarlyView.
Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey, Reena Lasrado, Maria Maiarú, Gary J. Stephens   +3 more
wiley   +1 more source

Overcoming the clinical challenges of traditional ayahuasca: a first-in-human trial exploring novel routes of administration of N,N-Dimethyltryptamine and harmine

Frontiers in Pharmacology, 2023
Recently, the Amazonian plant medicine “ayahuasca”—containing the psychedelic compound N,N-dimethyltryptamine (DMT) and numerous β-carboline alkaloids, such as harmine—has been suggested to exhibit beneficial effects in patients with affective and other ...
Dario Dornbierer, Laurenz Marten, Jovin Mueller, H. Aicher, Michael J. Mueller, M. Boxler, M. Kometer, Davor Kosanic, R. von Rotz, Maxim Puchkov, Thomas Kraemer, H. Landolt, Erich Seifritz, M. Scheidegger   +13 more
semanticscholar   +1 more source

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

Behavioral Changes Over Time Following Ayahuasca Exposure in Zebrafish

Frontiers in Behavioral Neuroscience, 2017
The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tribes.
Robson Savoldi, Daniel Polari, Jaquelinne Pinheiro-da-Silva, Priscila F. Silva, Bruno Lobao-Soares, Mauricio Yonamine, Fulvio A. M. Freire, Ana C. Luchiari   +7 more
doaj   +1 more source

Comparative oral monotherapy of psilocybin, lysergic acid diethylamide, 3,4-methylenedioxymethamphetamine, ayahuasca, and escitalopram for depressive symptoms: systematic review and Bayesian network meta-analysis

British medical journal
Objective To evaluate the comparative effectiveness and acceptability of oral monotherapy using psychedelics and escitalopram in patients with depressive symptoms, considering the potential for overestimated effectiveness due to unsuccessful blinding ...
Tien-Wei Hsu, Chia-Kuang Tsai, Yu-Chen Kao, Trevor Thompson, André F. Carvalho, Fu-Chi Yang, Ping-Tao Tseng, Chih-Wei Hsu, Chia-Ling Yu, Yu-Kang Tu, Chih-Sung Liang   +10 more
semanticscholar   +1 more source

A Systematic Review on the Therapeutic Effects of Ayahuasca

Plants, 2023
Traditional therapies, resorting to the use of plants, have acquired a great demand over the years, both for economic reasons and the preference for natural treatments.
Joana Gonçalves, Â. Luís, E. Gallardo, A. P. Duarte   +3 more
semanticscholar   +1 more source