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, 2007 Azathioprine is an orally active, immunosuppressive antimetabolite. It used to diminish the activity of the immune system as an antineoplastic agent. The mechanism of action of azathioprine involves inhibition of de novo purine synthesis after conversion
Robert J. Theobald, Theobald, Robert J.
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Journal of the American Academy of Dermatology, 1991
Azathioprine has been available for 30 years and is used in a variety of dermatologic conditions. In common with other systemic immunosuppressant drugs, it has potentially serious side effects in both the short and the long term. It has a favorable therapeutic ratio, however, and most side effects can be avoided by administering low doses for short ...
I R, Younger, D W, Harris, G B, Colver
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Azathioprine has been available for 30 years and is used in a variety of dermatologic conditions. In common with other systemic immunosuppressant drugs, it has potentially serious side effects in both the short and the long term. It has a favorable therapeutic ratio, however, and most side effects can be avoided by administering low doses for short ...
I R, Younger, D W, Harris, G B, Colver
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Azathioprine and the neurologist
Practical Neurology, 2019Neurologists are very familiar with using corticosteroids and are aware of their considerable risk of adverse effects with prolonged use. Thus, we frequently consider alternative immunosuppression or corticosteroid sparing agents. However, unlike other specialties, such as rheumatology, there are few indications for corticosteroid-sparing agents in ...
Matthew, McWilliam, Usman, Khan
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Anesthesiology, 1976
The neuromuscular effects of azathioprine were examined in the in-vivo cat soleus muscle preparation. In concentrations ranging from 10 to 1,000 mug/kg, administered intra-arterially, the agent caused motor axons to fire repetitively and produced a dose-related increase in the force of contraction. The drug reversed neuromuscular blockage produced by d-
K L, Dretchen +3 more
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The neuromuscular effects of azathioprine were examined in the in-vivo cat soleus muscle preparation. In concentrations ranging from 10 to 1,000 mug/kg, administered intra-arterially, the agent caused motor axons to fire repetitively and produced a dose-related increase in the force of contraction. The drug reversed neuromuscular blockage produced by d-
K L, Dretchen +3 more
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Archives of Internal Medicine, 1972
To the Editor. —Several points made by Shelp et al in "Effect of Azathioprine on Renal Histology in Lupus Nephritis in the October issue ( Arch Intern Med 128 :566-573, 1971) warrant comment. First, the authors do not mention their criteria for the diagnosis of systemic lupus erythematosus (SLE) and thus one does not know how the criteria of the ...
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To the Editor. —Several points made by Shelp et al in "Effect of Azathioprine on Renal Histology in Lupus Nephritis in the October issue ( Arch Intern Med 128 :566-573, 1971) warrant comment. First, the authors do not mention their criteria for the diagnosis of systemic lupus erythematosus (SLE) and thus one does not know how the criteria of the ...
openaire +2 more sources