Comprehensive overview of the global pharmacogenetic and functional variability in NUDT15 [PDF]
Human GenomicsThiopurine medications are widely used for the treatment of acute lymphoblastic leukemia and inflammatory bowel disease. However, thiopurine-induced hemotoxicity occurs in up to 30% of patients, which causes substantial morbidity and limits therapeutic ...
Yitian Zhou +2 more
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Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6‐Mercaptopurine Treatment [PDF]
Clinical and Translational ScienceThe nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) has been identified as a key genetic determinant of 6‐mercaptopurine (6‐MP)‐induced hematopoietic toxicity in populations with a high frequency of NUDT15 variants but a low frequency of ...
Kanyarat Khaeso +8 more
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Distribution of NUDT15*4 in Native American populations of the Brazilian Amazon and risk of intolerance to thiopurine drugs [PDF]
Frontiers in PharmacologyIntroductionTolerance to thiopurine drugs is modulated by polymorphisms in the TPMT and NUDT15 pharmacogenes, affecting the activity of the encoded TPMT and NUDT15 enzymes.
Guilherme Suarez-Kurtz +6 more
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Higher prevalence of NUDT15 rs116855232 compared to TPMT rs1142345 in a Chinese cohort and its implications for thiopurine therapy [PDF]
Frontiers in PharmacologyBackgroundThiopurine drugs are widely used as immunosuppressants and chemotherapeutic agents in clinical practice, but their adverse effects significantly limit their clinical application. TPMT c.719A>G (rs1142345) and NUDT15 c.415C>T (rs116855232)
Chenyu Zhao, Chenyu Zhao, Hui Huang
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Validation of diagnostic screening test for pharmacogenomic targets for thiopurine drugs in indian pediatric acute lymphoblastic leukemia patients [PDF]
Frontiers in PharmacologyBackgroundThiopurines such as 6-mercaptopurine (6-MP) are central to maintenance therapy for pediatric acute lymphoblastic leukemia (ALL), yet their narrow therapeutic index frequently causes dose-limiting myelosuppression in genetically susceptible ...
Gratial Theres Joseph +20 more
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NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy [PDF]
Medical SciencesThe management of acute lymphoblastic leukemia (ALL), the most common pediatric malignancy, critically relies on thiopurine therapy, such as 6-mercaptopurine (6-MP), during the maintenance phase. However, significant inter-individual response variety and
Isfahan Shah Lubis +5 more
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Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic RB1–NUDT15 Loss [PDF]
MedCommSomatic retinoblastoma 1 (RB1) loss is prevalent across different cancer types and is enriched in treatment‐refractory tumors, such as castration‐resistant prostate cancer (CRPC) and small‐cell lung cancer, but cannot be considered as a direct druggable ...
Tao Zhou +21 more
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Frontiers in Pharmacology, 2021 Backgound: The high incidence of thiopurine-induced myelosuppression in Asians is known to be attributable to genetic variation in thiopurine metabolism.
Kanyarat Khaeso +13 more
doaj +1 more source
Scientific Reports, 2023 Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, especially in the Asian ...
Chih-Hsiang Yu +17 more
doaj +1 more source
BMC Research Notes, 2022 Objective The nucleoside diphosphate linked moiety X (Nudix)-Type motif 15 (NUDT15) enzyme is involved in thiopurine metabolism. Genetic variants in the NUDT15 gene result in decreased NUDT15 activity, which in addition to decreased thiopurine S ...
Kok-Siong Poon +4 more
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