Results 1 to 10 of about 2,479 (192)

Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6‐Mercaptopurine Treatment [PDF]

Clinical and Translational Science
The nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) has been identified as a key genetic determinant of 6‐mercaptopurine (6‐MP)‐induced hematopoietic toxicity in populations with a high frequency of NUDT15 variants but a low frequency of ...
Kanyarat Khaeso, Su‐on Chainansamit, Pitchayanan Kuwatjanakul, Patcharee Komvilaisak, Nontaya Nakkam, Kunanya Suwannaying, Suda Vannaprasaht, Areerat Dornsena, Wichittra Tassaneeyakul   +8 more
doaj   +3 more sources

Pharmacogenomics of Thiopurine Drugs: A Bench‐To‐Bedside Success Story in Thailand [PDF]

Clinical and Translational Science
Thiopurine drugs are the cornerstone treatment for many diseases such as acute lymphoblastic leukemia (ALL), organ rejection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and other autoimmune diseases ...
Mohitosh Biswas, Shobana John, Murshadul Alam Murad, Chonlaphat Sukasem   +3 more
doaj   +3 more sources

NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir [PDF]

Nature Communications, 2021
Nucleoside analogs (NNA), such as acyclovir (ACV) and ganciclovir (GCV), are widely used as anti-virals to treat herpes virus infection. Here, Nishii et al.
Daniel Rehling, Xujie Zhao, Takaya Moriyama   +2 more
exaly   +4 more sources

Comprehensive overview of the global pharmacogenetic and functional variability in NUDT15 [PDF]

Human Genomics
Thiopurine medications are widely used for the treatment of acute lymphoblastic leukemia and inflammatory bowel disease. However, thiopurine-induced hemotoxicity occurs in up to 30% of patients, which causes substantial morbidity and limits therapeutic ...
Yitian Zhou, Lukas M. Lauschke, Volker M. Lauschke   +2 more
doaj   +2 more sources

Higher prevalence of NUDT15 rs116855232 compared to TPMT rs1142345 in a Chinese cohort and its implications for thiopurine therapy [PDF]

Frontiers in Pharmacology
BackgroundThiopurine drugs are widely used as immunosuppressants and chemotherapeutic agents in clinical practice, but their adverse effects significantly limit their clinical application. TPMT c.719A>G (rs1142345) and NUDT15 c.415C>T (rs116855232)
Chenyu Zhao, Chenyu Zhao, Hui Huang
doaj   +2 more sources

Distribution of NUDT15*4 in Native American populations of the Brazilian Amazon and risk of intolerance to thiopurine drugs [PDF]

Frontiers in Pharmacology
IntroductionTolerance to thiopurine drugs is modulated by polymorphisms in the TPMT and NUDT15 pharmacogenes, affecting the activity of the encoded TPMT and NUDT15 enzymes.
Guilherme Suarez-Kurtz, Anna Beatriz Ribeiro Elias, Marcelo Alex Carvaho, Alessandra Dias, Leonor Gusmão, Paulo Cesar Basta, Jamila Alessandra Perini   +6 more
doaj   +2 more sources

Repurposing Mercaptopurine Through Collateral Lethality to Treat Cancers with Somatic RB1–NUDT15 Loss [PDF]

MedComm
Somatic retinoblastoma 1 (RB1) loss is prevalent across different cancer types and is enriched in treatment‐refractory tumors, such as castration‐resistant prostate cancer (CRPC) and small‐cell lung cancer, but cannot be considered as a direct druggable ...
Tao Zhou, Huayun Yan, Dandan Yin, Yun Deng, Huancheng Fu, Zichen Zhao, Shuang Li, Xiaoxi Lu, Yiqi Deng, Hai‐Ning Chen, Wei‐Han Zhang, Yunying Shi, Yangjuan Bai, Bei Cai, Lanlan Wang, Zhaoqian Liu, Wei Zhang, Lili Jiang, Yang Shu, Bo Liu, Yan Zhang, Heng Xu   +21 more
doaj   +2 more sources

NUDT15 Pharmacogenetics in Acute Lymphoblastic Leukemia: Synthesizing Progress for Personalized Thiopurine Therapy [PDF]

Medical Sciences
The management of acute lymphoblastic leukemia (ALL), the most common pediatric malignancy, critically relies on thiopurine therapy, such as 6-mercaptopurine (6-MP), during the maintenance phase. However, significant inter-individual response variety and
Isfahan Shah Lubis, Kusnandar Anggadiredja, Aluicia Anita Artarini, Nur Melani Sari, Nur Suryawan, Zulfan Zazuli   +5 more
doaj   +2 more sources

Validation of diagnostic screening test for pharmacogenomic targets for thiopurine drugs in indian pediatric acute lymphoblastic leukemia patients [PDF]

Frontiers in Pharmacology
BackgroundThiopurines such as 6-mercaptopurine (6-MP) are central to maintenance therapy for pediatric acute lymphoblastic leukemia (ALL), yet their narrow therapeutic index frequently causes dose-limiting myelosuppression in genetically susceptible ...
Gratial Theres Joseph, Gratial Theres Joseph, Sandeep Kumar Swain, Tejas Somwanshi, Aarishi Singh, Manpreet Kaur, Raj Kamal, Himanshu Dhanda, Himanshu Dhanda, Prashant Kumar, Upasana Kaushik, Baseer Noor, Baseer Noor, Saurabh Sharma, Pranay Tanwar, Sufian Zaheer, Sumita Chaudhry, Prashant Prabhakar, Amitabh Singh, Bhavika Rishi, Aroonima Misra   +20 more
doaj   +2 more sources

Clinical Utility and Cost-Effectiveness of Pretreatment NUDT15 Pharmacogenetic Testing to Prevent Thiopurine-Induced Myelosuppression: A Genotype-First Reverse Phenotyping Cohort Study Within the UK NIHR Inflammatory Bowel Disease Bioresource. [PDF]

Aliment Pharmacol Ther
BackgroundThe clinical utility and cost-effectiveness of pre-thiopurine NUDT15 pharmacogenetic testing in European and admixed populations are unknown.AimsTo report the prevalence, penetrance, expressivity, and pathogenicity of NUDT15 variant allele ...
Roberts C, Peters J, Sazonvos A, Goodman N, Sharip M, Smith R, Bishara M, Bewshea C, Lin S, Chanchlani N, Hodges P, Badrulhisham F, Saifuddin A, Carlson S, Centritto A, Marley A, Saad M, Sethi-Aora K, White L, Abdelmeguid A, Pele L, Sebastian S, Selinger C, Irving P, Fachal L, Walker G, Palmer R, Kennedy N, Houghton J, Doona M, Lamb C, Hyde C, Parkes M, Goodhand J, Ahmad T.   +34 more
europepmc   +3 more sources