Results 1 to 10 of about 88,642,428 (226)

Preparation and characterization of 6-mercaptopurine-coated magnetite nanoparticles as a drug delivery system [PDF]

Drug Design, Development and Therapy, 2013
Dena Dorniani,1 Mohd Zobir bin Hussein,1 Aminu Umar Kura,2 Sharida Fakurazi,2 Abdul Halim Shaari,3 Zalinah Ahmad4 1Materials Synthesis and Characterization Laboratory, Institute of Advanced Technology, 2Vaccines and Immunotherapeutics Laboratory ...
Dorniani D, Hussein MZ, Kura AU, Fakurazi S, Shaari AH, Ahmad Z   +5 more
doaj   +2 more sources

Toxicity of azathioprine: why and when? analysis of the prevalence of polymorphism in Joinville, SC, Brazil

Arquivos de Gastroenterologia, 2012
CONTEXT: The use of thiopurine drugs such as azathioprine and 6-mercaptopurine has become quite common in the treatment of inflammatory bowel disease, transplantation and acute leukemias.
Gabriela Roncone Gastal, Simone Moreira, Caroline Furtado Noble, Leslie Ecker Ferreira, Paulo Henrique Condeixa de França, Mauro Pinho   +5 more
doaj   +1 more source

Effect of Smart Pill Box on Improving Adherence to 6-Mercaptopurine Maintenance Therapy in Pediatric ALL

Indian Journal of Medical and Paediatric Oncology
Introduction 6-Mercaptopurine (6-MP) forms the backbone of maintenance chemotherapy for acute lymphoblastic leukemia (ALL). A Children's Oncology Group study found 3.9-fold increased risk of relapse in children with 6-MP adherence less than 90%
S. Abhilasha, Apoorva Bagalkotkar
doaj   +1 more source

Simultaneous Analysis of 6-Mercaptopurine, 6-Methylmercaptopurine, and 6-Thioguanosine-5’-monophosphate in Dried Blood Spot Using Ultra Performance Liquid Chromatography Tandem Mass Spectrometry

Indonesian Journal of Chemistry, 2018
6-Mercaptopurine is a chemotherapeutic agent of the antimetabolite class. This study aims to analyze simultaneous validation of 6-mercaptopurine (6-MP), 6-methylmercaptopurine (6-MMP), and 6-thioguanosine-5’-monophosphate (6-TGMP) in dried blood spot ...
Supandi Supandi, Yahdiana Harahap, Harmita Harmita, Rizka Andalusia   +3 more
doaj   +1 more source

The frequency of NUDT15 rs116855232 and its impact on mercaptopurine-induced toxicity in Syrian children with acute lymphoblastic leukemia

Frontiers in Oncology
IntroductionPolymorphisms in NUDT15 may result in differences in mercaptopurine-induced toxicity. This study aimed to identify the frequency of the NUDT15 (c.415C>T; rs116855232) polymorphism and investigate the effect of this polymorphism on ...
Muhammad Muhammad, Muhammad Muhammad, Maher Saifo, Maher Saifo, Majd Aljamali, Majd Aljamali, Mousa Alali, Khaled M. Ghanem   +7 more
doaj   +1 more source

Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia [version 1; referees: 2 approved]

F1000Research, 2019
Fasting hypoglycemia is a known complication of mercaptopurine (6MP) maintenance therapy for acute lymphoblastic leukemia (ALL). It is associated with high levels of the methylated metabolite 6-methyl-mercaptopurine (6MMP).
Melissa Zhang, Bruce Bostrom
doaj   +1 more source

Optimizing therapy in pediatric acute lymphoblastic leukemia (ALL ): the crucial role of monitoring 6-mercaptopurine metabolites

Medicina Universitaria
Acute lymphoblastic leukemia (ALL) is the most prevalent form of cancer in children, and maintenance therapy with 6-mercaptopurine (6-MP) is crucial for treating these patients.
Ana L. Valdez-Arellanes, Lourdes Garza-Ocañas, Christian T. Badillo-Castañeda   +2 more
doaj   +1 more source

Does CytoSorb Interfere with Immunosuppression? A Pharmacokinetic and Functional Evaluation

Pharmaceutics
Background/Objectives: Cytokine release during organ transplantation contributes to primary graft dysfunction and requires careful immunomodulation. CytoSorb, a hemoadsorption device developed to reduce circulating cytokine levels, is increasingly used ...
Stephan Harm, Claudia Schildböck, Denisa Cont, Viktoria Weber, Jens Hartmann   +4 more
doaj   +1 more source

An improved HPLC method for the quantitation of 6-mercaptopurine and its metabolites in red blood cells

Brazilian Journal of Medical and Biological Research, 2004
A procedure is described for the rapid determination of the intra-erythrocyte concentration of 6-mercaptopurine (6-MP) and its metabolites, 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP).
B.M. Oliveira, A.J. Romanha, T.M.A. Alves, M.B. Viana, C.L. Zani   +4 more
doaj   +1 more source

Allopurinol reverses mercaptopurine-induced hypoglycemia in patients with acute lymphoblastic leukemia [version 2; peer review: 2 approved]

F1000Research, 2019
Fasting hypoglycemia is a known complication of mercaptopurine (6MP) maintenance therapy for acute lymphoblastic leukemia (ALL). It is associated with high levels of the methylated metabolite 6-methyl-mercaptopurine (6MMP).
Melissa Zhang, Bruce Bostrom
doaj   +1 more source