Toxicity evaluation of 6-mercaptopurine-Chitosan nanoparticles in rats [PDF]
Saudi Pharmaceutical Journal, 2020 Background: The 6-mercaptopurine (6-MP) is an effective immunosuppressant and anti-cancer drug. However, the usage of 6-MP is limited due to its well-known side effects, such as myelotoxicity and hepato-renal toxicity.
Prem Kumar Govindappa +4 more
doaj +3 more sources
Electrochemical sensing platform for simultaneous detection of 6-mercaptopurine and 6-thioguanine using RGO-Cu2O/Fe2O3 modified screen-printed graphite electrode [PDF]
Journal of Electrochemical Science and Engineering, 2021 A sensitive electrochemical sensor was developed using reduced graphene oxide RGO-Cu2O/Fe2O3 nanocomposite for 6-mercaptopurine detection based on a facile fabrication method.
Fatemeh Irannezhad +2 more
doaj +2 more sources
Antiviral Potential of Azathioprine and Its Derivative 6- Mercaptopurine: A Narrative Literature Review [PDF]
PharmaceuticalsThe use of azathioprine (AZA) in human medicine dates back to research conducted in 1975 that led to the development of several drugs, including 6-mercaptopurine.
Carolina Rios-Usuga +2 more
doaj +2 more sources
Effects of allopurinol on 6-mercaptopurine metabolism in unselected patients with pediatric acute lymphoblastic leukemia: a prospective phase II study [PDF]
HaematologicaAllopurinol can be used in maintenance therapy (MT) for pediatric acute lymphoblastic leukemia (ALL) to mitigate hepatic toxicity in patients with skewed 6- mercaptopurine metabolism.
Jonatan Källström +10 more
doaj +2 more sources
gene variants and thiopurine-induced leukopenia in patients with inflammatory bowel disease [PDF]
Intestinal Research, 2020 Thiopurine has been used to maintain remission and to reduce antidrug antibody formation in monoclonal antibody therapy in patients with inflammatory bowel disease (IBD). The use of thiopurine is limited by side effects such as leukopenia.
Katsuyoshi Matsuoka
doaj +1 more source
Effects of 6– Mercaptopurine on Salivary Glands in Rabbit [PDF]
Al-Rafidain Dental Journal, 2012 To study the effect of 6 – Mercaptopurine on salivary glands of rabbits. Materials and Methods: This study was carried out on 6 young rabbits of both sexes, aged 2 – 3 months, and weighing 1.250-1.350 Kg.
Alhan D Al–Moula +2 more
doaj +1 more source
Pharmaceuticals, 2021 In this work, a systematical compatibility investigation of 6-mercaptopurine and folic acid, two commonly used medications in the treatment of inflammatory bowel disease, for the needs of a fixed-dose combination development strategy is shown.
Edvin Brusač +5 more
doaj +1 more source
Scientific Reports, 2023 Mercaptopurine intolerance is an adverse effect of mercaptopurine administration in pediatric patients with acute lymphoblastic leukemia (ALL). NUDT15 variants have emerged as major determinants of mercaptopurine intolerance, especially in the Asian ...
Chih-Hsiang Yu +17 more
doaj +1 more source
Ars Pharmaceutica, 2023 A 6-year-old girl diagnosed with intermediate-risk acute lymphoblastic leukemia (ALL) presented with severe myelotoxicity and multiple infections during phase IB induction treatment with 6-mercaptopurine (6-MP).
Laura Elena Pineda-Lancheros +5 more
doaj +1 more source
Pharmacogenetic Testing for the Pediatric Gastroenterologist: Actionable Drug–Gene Pairs to Know
Pharmaceuticals, 2023 Gastroenterologists represent some of the earlier adopters of precision medicine through pharmacogenetic testing by embracing upfront genotyping for thiopurine S-methyltransferase nucleotide diphosphatase (TPMT) before prescribing 6-mercaptopurine or ...
Tracy Sandritter +3 more
doaj +1 more source