Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase-catalyzed xanthine and 6-mercaptopurine oxidation. [PDF]
J Sci Food AgricAbstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Bencsik T +6 more
europepmc +2 more sources
6-Mercaptopurine teratogenicity [PDF]
Postgraduate Medical Journal, 2002 We read with interest the review article on inflammatory bowel disease (IBD) in pregnancy.1 The author mentions that there has never been any demonstration of teratogenicity of 6-mercaptopurine (or azathioprine) in humans. We would like to report a case, which we encountered, of an infant with multiple congenital abnormalities whose mother received 6 ...
D H Tegay, R Tepper, J P Willner
openaire +1 more source
6-Mercaptopurine, Monocytes, and Atherosclerosis [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2010 Atherosclerosis, the underlying cause of heart attack and stroke, appears to be an inflammatory disease driven by retention of modified lipoproteins in the artery wall.1 Markers of inflammation, such as high sensitivity C-reactive protein, are independent predictors of cardiovascular (CV) events.2 If atherosclerosis truly is an inflammatory disease ...
Macrae F, Linton, Sergio, Fazio
openaire +2 more sources
Pharmacogenetic Testing for the Pediatric Gastroenterologist: Actionable Drug–Gene Pairs to Know
Pharmaceuticals, 2023 Gastroenterologists represent some of the earlier adopters of precision medicine through pharmacogenetic testing by embracing upfront genotyping for thiopurine S-methyltransferase nucleotide diphosphatase (TPMT) before prescribing 6-mercaptopurine or ...
Tracy Sandritter +3 more
doaj +1 more source
Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn’s disease [PDF]
, 2014 Background Crohn’s disease (CD) is a chronic relapsing inflammatory condition. Many patients fail to achieve remission with medical management and require surgical interventions.
Angelberger +41 more
core +1 more source
AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury
, 2022 Hepatology, EarlyView.
Robert J. Fontana +6 more
wiley +1 more source
Safety aspects of infliximab in inflammatory bowel disease patients - A retrospective cohort study in 100 patients of a German University Hospital [PDF]
, 2004 Background: Infliximab, a chimeric anti-tumour necrosis factor monoclonal antibody with potent anti-inflammatory effects, represents an effective treatment option in patients with severe inflammatory bowel disease (IBD).
Ali Y +11 more
core +1 more source
CAQ Corner: Basic concepts of transplant immunology
, 2022 Liver Transplantation, EarlyView.
Amanda Cheung, Josh Levitsky
wiley +1 more source
Effects of 6-mercaptopurine in pressure overload induced right heart failure.
PLoS ONE, 2019 BackgroundSeveral antineoplastic drugs have been proposed as new compounds for pulmonary arterial hypertension treatment but many have cardiotoxic side effects.
Julie Birkmose Axelsen +10 more
doaj +1 more source
Biosensors, 2021 Hypoxanthine (hpx) is an important molecule for both biochemistry research and biomedical applications. It is involved in several biological processes associated to energy and purine metabolism and has been proposed as a biomarker for a variety of ...
Marta Orts-Arroyo +2 more
doaj +1 more source