Results 31 to 40 of about 9,465,904 (238)

In vitro Anti-inflammatory Evaluation of 6-Thioguanine and 6-Hydroxy-2-Mercaptopurine as A Potential Treatment for Rheumatoid Arthritis

Indonesian Biomedical Journal, 2021
BACKGROUND: Eventhough 6-Mercaptopurine act as a major drug for rheumatoid arthritis (RA) treatment, however, its toxicity become a limitation. Therefore, this current study investigated whether 6-hydroxy-2-mercaptopurine (6H2MP) and 6-thioguanine (6TG ...
Nurul Syuhada Nordin, Yong Yoke Keong, Siti Farah Md Tohid, Zetty Nadia Md Zain, Muhammad Nazrul Hakim   +4 more
doaj   +1 more source

Theoretical EPR study of 6-Mercaptopurine

, 2017
32nd International Physics Congress of Turkish-Physical-Society (TPS) -- SEP 06-09, 2016 -- Bodrum, TURKEY6-Mercaptopurine is important antineoplastics agent and it is used for immuno suppressive and anti inflammatory.
Ercan Türkkan, Tasdemir, Halil Ugur, Turkkan, Ercan, Halil Ugur Tasdemir   +3 more
core   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen, Fariha Balouch, Claire Reilly, Christopher Burgess, Peter Lewindon   +4 more
wiley   +1 more source

Potentiometric and volumetric determination of 6-mercaptopurine

, 1990
Three methods for the determination of 6-mercaptopurine in the pure state and in tablets are described. One method is based on the reaction of this compound with silver ions, whereby an equivalent amount of nitric acid is liberated, the latter being ...
Nikolić, Kosta, Velašević, Ksenija
core   +1 more source

Intramolecular Charge Transfer in the Azathioprine Prodrug Quenches Intersystem Crossing to the Reactive Triplet State in 6-Mercaptopurine [PDF]

, 2021
The thiopurine prodrugs 6-mercaptopurine and azathioprine are among the world’s essential medications for acute lymphoblastic leukemia, immunosuppression, and several autoimmune conditions.
Sean J., Hoehn, Luis A., Ortiz-Rodríguez, Glesmarie, Ortiz-Zayas, Marvin, Pollum, Steffen, Jockusch, Carlos, Crespo-Hernández   +5 more
core   +1 more source

Polymer-Based Nanoparticles as Drug Delivery Systems for Purines of Established Importance in Medicine

Nanomaterials, 2023
Many purine derivatives are active pharmaceutical ingredients of significant importance in the therapy of autoimmune diseases, cancers, and viral infections.
Piotr Szyk, Beata Czarczynska-Goslinska, Dariusz T. Mlynarczyk, Barbara Ślusarska, Tomasz Kocki, Marta Ziegler-Borowska, Tomasz Goslinski   +6 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

RESISTANCE TO 6-MERCAPTOPURINE: II THE SYNTHESIS OF THIOINOSINATE IN A 6-MERCAPTOPURINE-RESISTANT SUBLINE OF THE EHRLICH ASCITES CARCINOMA

, 1962
An assay for the synthesis of thioinosinate by the nucleotide pyrophosphorylase reaction in tissue extracts has been developed and has been applied in a comparison of the Ehrlich ascites carcinoma and a 6-mercaptopurine-resistant subline.
A. R. P. Paterson
core   +1 more source

A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation

Journal of Analytical Methods in Chemistry, 2019
The development of a reliable electrochemical sensor using a hybrid nanocomposite consisting of ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) functionalized graphene oxide (GrO-IL) and gold nanoparticles (AuNPs) stabilized by chitosan ...
Liliya K. Shpigun, Elena Yu. Andryukhina
doaj   +1 more source

Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol

BMC Cancer, 2022
Background A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse.
Linea Natalie Toksvang, Bodil Als-Nielsen, Christopher Bacon, Ruta Bertasiute, Ximo Duarte, Gabriele Escherich, Elín Anna Helgadottir, Inga Rinvoll Johannsdottir, Ólafur G. Jónsson, Piotr Kozlowski, Cecilia Langenskjöld, Kristi Lepik, Riitta Niinimäki, Ulrik Malthe Overgaard, Mari Punab, Riikka Räty, Heidi Segers, Inge van der Sluis, Owen Patrick Smith, Marion Strullu, Goda Vaitkevičienė, Hilde Skuterud Wik, Mats Heyman, Kjeld Schmiegelow   +23 more
doaj   +1 more source