Results 31 to 40 of about 88,642,428 (226)

The effect of 6-mercaptopurine on natural killer-cell activities in Crohn's disease [PDF]

, 1985
Crohn's disease patients on long-term 6-mercaptopurine therapy (more than 4 months) were evaluated for activity of peripheral blood natural killer cells. Natural killer-cell cytolytic activity against K-562 tumor-cell targets was examined, as was natural
R. Stevens, B. Korelitz, Stevens, R., M. Oliver, S. Targan, Targan, S., M. Brogan, Oliver, M., Hiserodt, J. C., J. Hiserodt, Korelitz, B., Brogan, M.   +11 more
core   +1 more source

Detection of Hypoxanthine from Inosine and Unusual Hydrolysis of Immunosuppressive Drug Azathioprine through the Formation of a Diruthenium(III) System

Biosensors, 2021
Hypoxanthine (hpx) is an important molecule for both biochemistry research and biomedical applications. It is involved in several biological processes associated to energy and purine metabolism and has been proposed as a biomarker for a variety of ...
Marta Orts-Arroyo, Isabel Castro, José Martínez-Lillo   +2 more
doaj   +1 more source

Chromatographic Method for Determining 6‑Mercaptopurine in Skin Permeation Assays for Assessing Cutaneous Exposure Risk [PDF]

ACS Omega
Gabriel S. Oliveira, Ana Luiza Lima, Idejan P. Gross, Livia Sa-Barreto, Patrícia Medeiros-Souza, Tais Gratieri, Guilherme M. Gelfuso, Marcilio Cunha-Filho   +7 more
doaj   +2 more sources

Impact of 6-Mercaptopurine on Enteric Gliosis [PDF]

, 2023
Inflammatory diseases of the gut, such as ulcerative colitis and Crohn’s disease, are a persistent burden for many patients all over the world. Interestingly, a growing body of evidence indicates that the enteric nervous system and especially enteric ...
Kneusels, Jan Friedel
core   +1 more source

Cyclophosphamide: An Alternative Treatment in Crohn’s Disease

Canadian Journal of Gastroenterology, 1989
lmmunosuppressive therapy in the form of 6-mercaptopurine has shown a 66% efficacy in severe, debilitating, highly corticosteroid dependent Crohn’s disease. Nevertheless this medication has some important side effects such as nausea, vomiting, leukopenia
Gilles Lapointe, Aubin Charbonneau
doaj   +1 more source

Physiologically based pharmacokinetic modelling of methotrexate and 6-mercaptopurine in adults and children

, 2022
This project\u27s goal is to observe how the leukemia drug 6-mercaptopurine (6-MP) interacts with the ...
Hunt, Arabella
core   +2 more sources

Variants in TPMT, ITPA, ABCC4 and ABCB1 genes as predictors of 6-mercaptopurine induced toxicity in children with acute lymphoblastic leukemia [PDF]

Journal of Medical Biochemistry, 2018
Background: Acute lymphoblastic leukemia is the most common childhood malignancy. Optimal use of anti leukemic drugs has led to less toxicity and adverse reactions, and a higher survival rate. Thiopurine drugs, including 6-mercaptopurine, are mostly used
Milošević Goran, Kotur Nikola, Krstovski Nada, Lazić Jelena, Zukić Branka, Stanković Biljana, Janić Dragana, Katsila Theodora, Patrinos George P., Pavlović Sonja, Dokmanović Lidija   +10 more
doaj  

Crystal structures of five 6-mercaptopurine derivatives

Acta Crystallographica Section E: Crystallographic Communications, 2016
The crystal structures of five 6-mercaptopurine derivatives, viz. 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(3-methoxyphenyl)ethan-1-one (1), C16H14N4O3S, 2-[(9-acetyl-9H-purin-6-yl)sulfanyl]-1-(4-methoxyphenyl)ethan-1-one (2), C16H14N4O3S, 2-[(9-acetyl-9H ...
Lígia R. Gomes, John Nicolson Low, Diogo Magalhães e Silva, Fernando Cagide, Fernanda Borges   +4 more
doaj   +1 more source

Thiopurine S-Methyltransferase Polymorphism in Iraqi Paediatric Patients with Acute Lymphoblastic Leukaemia [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Acute Lymphoblastic Leukaemia (ALL) treatment protocols widely used thiopurine drugs as an anti-cancer agent, which over the course of time results in drug toxicity.
NAWARS MOHAMMED, MANALK RASHEED, HASANEIN H GHALI   +2 more
doaj   +1 more source

Impact of 6-mercaptopurine and 6-mercaptopurine riboside on pro-inflammatory cytokines and oxidative stress in blood plasma of rats with complete Freund’s adjuvant (CFA) arthritis

Life Sciences, Medicine and Biomedicine
Inflammatory arthritis is a chronic autoimmune disorder characterized by joint inflammation and pain, often requiring effective immunosuppressive treatment. In a rat model of inflammatory arthritis, the anti-immunosuppressive effects of 6-mercaptopurine
Che Ku Dahlan-Daud, Zetty Nadia Zain, Chau Ling Tham, Yoke Keong Yong , Muhammad Nazrul Hakim   +4 more
doaj   +1 more source