Results 1 to 10 of about 76,298 (277)
A Case of Azathioprine Induced Severe Myelosuppression and Alopecia Totalis in IgA Nephropathy [PDF]
Childhood Kidney Diseases, 2017 Azathioprine is commonly used as immunosuppressive therapy for various inflammatory diseases including chronic glomerulonephritis. Myelosuppression is a common side effect of azathioprine, resulting in the need for dose reduction.
Jae Choon Kim +6 more
doaj +1 more source
Sensing Methods of Immunosuppressant Drugs: Calcineurin Inhibitors and Purine Synthesis Inhibitor Agents [PDF]
ImmunoAnalysis, 2021 Today, immunosuppression is associated as a necessary protocol in renal posttransplantation follow-up to improve both patient and graft survival rates.
Zahra Golsanamlou +2 more
doaj +1 more source
Azathioprine versus beta interferons for relapsing-remitting multiple sclerosis: a multicentre randomized non-inferiority trial. [PDF]
PLoS ONE, 2014 For almost three decades in many countries azathioprine has been used to treat relapsing-remitting multiple sclerosis. However its efficacy was usually considered marginal and following approval of β interferons for this indication it was no longer ...
Luca Massacesi +10 more
doaj +1 more source
Journal of Nepal Medical Association, 2016 Introduction: Immune thrombocytopenic purpura remains common blood disease in Nepal. Azathioprine is an oral immunosupressive medicine which has been used widely in various autoimmune disease and solid organ transplant patients. It is inexpensive, easily
Bishesh Sharma Poudyal +5 more
doaj +3 more sources
Clinical and Translational Science, 2022 TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also contribute to azathioprine myelotoxicity.
Laura L. Daniel +17 more
doaj +1 more source
IMMUNOTOXICITY EFFECT OF LAVENDER (Lavendula Spica) FLOWERS POWDER AND OIL ON AZATHIOPRINE INDUCED TOXICITY IN EXPERIMENTAL RATS [PDF]
مجلة دراسات و بحوث التربیة النوعیة, 2016 Objective: The present study aims to investigate the possible protective effects of lavender flowers powder and oil alone to healthy rats and against azathioprine induced toxicity of immune in rats.
لبنى احمد شلباية +1 more
doaj +1 more source
Taiwanese Journal of Obstetrics & Gynecology, 2023 Objective: Azathioprine, a prodrug of 6-mercaptopurine (6-MP), is used in the treatment of inflammatory bowel disease and may be continued during pregnancy. Acute cholestatic liver injury has been reported to occur with azathioprine.
Maya Frank Wolf +6 more
doaj +1 more source
Prevention of thiopurine-induced early leukopenia in a Korean pediatric patient with Crohn’s disease who turned out to possess homozygous mutations in R139C [PDF]
Yeungnam University Journal of Medicine, 2020 Homozygous mutations in NUDT15 R139C are known as the major factor associated with thiopurine-induced early leukopenia, particularly in Asian patients. Therefore, NUDT15 genotyping is currently recommended before thiopurine treatment to identify patients
Jaewoan Bae, Byung-Ho Choe, Ben Kang
doaj +1 more source
Azathioprine antagonizes aberrantly elevated lipid metabolism and induces apoptosis in glioblastoma
iScience, 2021 Summary: Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor with poor survival rate. Temozolomide (TMZ) is used as standard chemotherapy to treat GBM, but a large number of patients either respond poorly and/or develop resistance ...
Hye Jin Nam +8 more
doaj +1 more source
Journal of Kerbala for Agricultural Sciences, 2023 The present study aimed to reveal the biological vitality of the immune suppressant medicine azathioprine (AZA), which has been used to treat immunological illnesses like acute lymphoblastic leukemia (ALL), inflammatory bowel disease, and organ ...
Ahmed Al-Hasnawi, Wafaa Kadhim Jasim
doaj +1 more source