IMMUNOTOXICITY EFFECT OF LAVENDER (Lavendula Spica) FLOWERS POWDER AND OIL ON AZATHIOPRINE INDUCED TOXICITY IN EXPERIMENTAL RATS [PDF]
مجلة دراسات و بحوث التربیة النوعیة, 2016 Objective: The present study aims to investigate the possible protective effects of lavender flowers powder and oil alone to healthy rats and against azathioprine induced toxicity of immune in rats.
لبنى احمد شلباية +1 more
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Azathioprine antagonizes aberrantly elevated lipid metabolism and induces apoptosis in glioblastoma
iScience, 2021 Summary: Glioblastoma multiforme (GBM) is the most aggressive type of brain tumor with poor survival rate. Temozolomide (TMZ) is used as standard chemotherapy to treat GBM, but a large number of patients either respond poorly and/or develop resistance ...
Hye Jin Nam +8 more
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Prevention of thiopurine-induced early leukopenia in a Korean pediatric patient with Crohn’s disease who turned out to possess homozygous mutations in R139C [PDF]
Yeungnam University Journal of Medicine, 2020 Homozygous mutations in NUDT15 R139C are known as the major factor associated with thiopurine-induced early leukopenia, particularly in Asian patients. Therefore, NUDT15 genotyping is currently recommended before thiopurine treatment to identify patients
Jaewoan Bae, Byung-Ho Choe, Ben Kang
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Case Reports in Pulmonology, 2020 Azathioprine is used to treat anti-neutrophil cytoplasmic antibody- (ANCA-) associated vasculitis. Azathioprine hypersensitivity syndrome is often missed.
Eri Nakano +5 more
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Change in hematologic indices over time in pediatric inflammatory bowel disease treated with azathioprine [PDF]
, 2010 Azathioprine leads to changes in mean corpuscular volume (MCV) and white blood cell (WBC) indices reflecting efficacy or toxicity. Understanding the interactions between bone marrow stem cells and azathioprine could highlight abnormal response patterns ...
Cordell, Samantha J. +11 more
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Bioscience Journal, 2021 This study was performed to evaluate the effectiveness of Echinacea purpurea (E.P.) on azathioprine (AZA)-induced immune deficiency in albino rats. Thirty six male albino rats were divided into six equal groups.
Emad Mohamed El-Sherbiny +2 more
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Azathioprine-induced accelerated cutaneous and pulmonary nodulosis in a patient with rheumatoid arthritis [PDF]
Anais Brasileiros de Dermatologia, 2015 We report the case of a 42-year-old female with a 5-year history of rheumatoid arthritis treated with Rituximab and Azathioprine. Three months after the initiation of Azathioprine, the patient started with dry cough and noted the rapid development of ...
Cristian Vera Kellet +3 more
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6-thioguanine treatment in inflammatory bowel disease: A critical appraisal by a European 6-TG working party [PDF]
, 2006 Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004,
Seiderer, J. +34 more
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Biosensors, 2021 Hypoxanthine (hpx) is an important molecule for both biochemistry research and biomedical applications. It is involved in several biological processes associated to energy and purine metabolism and has been proposed as a biomarker for a variety of ...
Marta Orts-Arroyo +2 more
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Thiopurine methyltransferase genotype and activity cannot predict outcomes of azathioprine maintenance therapy for antineutrophil cytoplasmic antibody associated vasculitis: A retrospective cohort study. [PDF]
PLoS ONE, 2018 Azathioprine is a widely used immunosuppressive drug. Genetic polymorphisms and activity of the enzyme thiopurine methyltransferase (TPMT) have been associated with azathioprine efficacy and toxicity in several populations.
Arno C Hessels +3 more
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