Results 21 to 30 of about 63,234 (249)

Association Between Genetic Polymorphisms of Metabolic Enzymes and Azathioprine-Induced Myelosuppression in 1,419 Chinese Patients: A Retrospective Study

Frontiers in Pharmacology, 2021
The aim of this study was to investigate the correlation between genetic polymorphisms of azathioprine-metabolizing enzymes and adverse reactions of myelosuppression. To this end, a retrospective analysis was performed on 1,419 Chinese patients involving
Zhao-Yang Chen, Yang-Hui Zhu, Ling-Yan Zhou, Wei-Qiao Shi, Zhou Qin, Bin Wu, Yu Yan, Yu-Wen Pei, Ning-Ning Chao, Rui Zhang, Mi-Ye Wang, Ze-Hao Su, Xiao-Jun Lu, Zhi-Yao He, Zhi-Yao He, Ting Xu, Ting Xu   +16 more
doaj   +1 more source

Azathioprine favourably influences the course of malaria

Malaria Journal, 2009
Background Azathioprine triggers suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and exposure of phosphatidylserine at the erythrocyte surface. Eryptosis may accelerate the clearance of Plasmodium-infected erythrocytes.
Huber Stephan M, Föller Michael, Geiger Corinna, Koka Saisudha, Bobbala Diwakar, Lang Florian   +5 more
doaj   +1 more source

Optical Coherence Tomography Reveals Longitudinal Changes in Retinal Damage Under Different Treatments for Neuromyelitis Optica Spectrum Disorder

Frontiers in Neurology, 2021
Background: Progressive retinal neuroaxonal damage after acute optic neuritis may occur in neuromyelitis optica spectrum disorder (NMOSD). However, it is unclear if treatments used to prevent attacks influence neurodegeneration.Objectives: We aimed to ...
Pei Zeng, Chen Du, Rui Zhang, Dongmei Jia, Feng Jiang, Moli Fan, Chao Zhang   +6 more
doaj   +1 more source

Increased Risk of Liver Cirrhosis during Azathioprine Therapy for Crohn’s Disease

Case Reports in Gastrointestinal Medicine, 2020
Azathioprine is a cornerstone of the therapy of Crohn’s disease. Unfortunately, infections and malignancies are relatively common adverse effects related to this drug; however, cirrhosis is exceptionally reported as a side effect. We report the case of a
Jenny Roselli, Tommaso Innocenti, Erica Nicola Lynch, Laura Parisio, Giuseppe Macrì, Monica Milla, Tommaso Mello, Andrea Galli, Stefano Milani, Mirko Tarocchi   +9 more
doaj   +1 more source

Immunoglobulin G4-Hepatopathy with Acute Hepatitis-Like Onset and Marked Centrilobular Necrosis: Clinicopathologically Unique Pattern of Hepatic Injury Related to Immunoglobulin G4-Related Disease

Case Reports in Gastroenterology, 2021
A 69-year-old man presented with jaundice and appetite loss. Blood analyses showed elevated aminotransferase levels, hyperbilirubinemia, positivity for antinuclear antibody, elevated immunoglobulin (Ig) G4 levels, and negativity for hepatitis virus ...
Kaori Mukai, Tsutomu Nishida, Shiro Adachi, Kengo Matsumoto, Naoto Osugi, Aya Sugimoto, Dai Nakamatsu, Masashi Yamamoto, Koji Fukui, Hiromi Tamura, Masami Inada   +10 more
doaj   +1 more source

Azathioprine-Induced Acute Submandibular Sialadenitis in a Crohn’s Disease Patient

GE: Portuguese Journal of Gastroenterology, 2020
Introduction: Azathioprine (AZA) is a widely used immunosuppressive drug in inflammatory bowel disease (IBD). The occurrence of adverse effects (AEs) is a major downside in the use of this drug, leading to treatment withdrawal in a variable proportion of
Joana Inês Alves da Silva, Cidalina Caetano, Isabel Pedroto   +2 more
doaj   +1 more source

Hard-To-Treat Idiopathic Refractory Autoimmune Haemolytic Anaemia with Reticulocytopenia

European Journal of Case Reports in Internal Medicine, 2020
Autoimmune haemolytic anaemia (AIHA) is an uncommon condition characterized by increased destruction of erythrocytes associated with reticulocytosis in the great majority of cases.
Marcelo Aveiro, Gisela Ferreira, Carla Matias, Ana Oliveira, Tatiana Rodrigues   +4 more
doaj   +1 more source

A Real-World Experience of Azathioprine Versus First-Line Disease-Modifying Therapy in Relapsing-Remitting Multiple Sclerosis—A Prospective Cohort Study

Brain Sciences, 2023
Azathioprine (AZA) has demonstrated efficacy in multiple randomized control trials (RCTs) for Relapsing-Remitting Multiple Sclerosis (RRMS). However, we still need comparative real-world data with other first-line disease-modifying therapies (DMTs).
Arpit Agrawal, M. V. Padma Srivastava, Rohit Bhatia, Vinay Goyal, Mamta Bhushan Singh, Venugopalan Y. Vishnu, Anuj Prabhakar   +6 more
doaj   +1 more source

Influence of probiotics and deoxycholate on azathioprine transport in the PAMPA model: insights into pharmacomicrobiomics and interindividual variability in drug response

Frontiers in Pharmacology
IntroductionInterindividual variability in drug response presents a major clinical challenge, necessitating a deeper understanding of contributing factors.
Maja Đanić, Nebojša Pavlović, Natalija Dedić, Dragana Zaklan, Slavica Lazarević, Bojan Stanimirov, Momir Mikov   +6 more
doaj   +1 more source

Acute pancreatitis in a kidney transplant recipient and proposal of a step-wise diagnostic algorithm - A case report

Indian Journal of Transplantation, 2021
Acute pancreatitis (AP) is a rarely encountered complication in patients following kidney transplantation and is associated with significant morbidity and mortality.
Praveen Kumar Etta, Thatipamula Madhavi, Namrata Parikh   +2 more
doaj   +1 more source