Results 31 to 40 of about 71,298 (290)

Acute-onset Alopecia in a Child: A Surrogate Marker of Azathioprine-induced Myelotoxicity

Indian Journal of Paediatric Dermatology, 2023
Azathioprine (AZA) is a widely used immunosuppressive which when not monitored cautiously can lead to life-threatening complications like myelotoxicity. In resource-limited countries, acute hair loss starting as early as 2 weeks after drug initiation can
Vibhu Mendiratta, Akanksha Agarwal, Smita Singh   +2 more
doaj   +1 more source

Efficacy and Safety of Rituximab in Immunobullous Diseases: A Retrospective Study from a Tertiary Care Centre of Nepal [PDF]

Journal of Clinical and Diagnostic Research, 2020
Introduction: Rituximab is effective and safe treatment of immunobullous disorders. There are variations in doses of drugs used in different studies and uncertainties on when to use it along with use of adjuvant therapies. Efficacy and safety of this
Sudip Parajuli, Jyoti Vidhan, Dinesh Binod Pokhrel, Upama Paudel   +3 more
doaj   +1 more source

Azathioprine shock [PDF]

Postgraduate Medical Journal, 1986
Summary Azathioprine has been used as an immunosuppressant for over 20 years in cancer chemotherapy, organ transplantation and diseases with confirmed or suspected immune mechanisms. A hypersensitivity reaction manifesting as fever, rash, myalgia and a neutrophil leucocytosis occurring about 2 weeks after exposure is well documented and ...
openaire   +2 more sources

Use of thiopurines in inflammatory bowel disease: an update [PDF]

Intestinal Research, 2022
Inflammatory bowel disease (IBD), once considered a disease of the Western hemisphere, has emerged as a global disease. As the disease prevalence is on a steady rise, management of IBD has come under the spotlight.
Arshdeep Singh, Ramit Mahajan, Saurabh Kedia, Amit Kumar Dutta, Abhinav Anand, Charles N. Bernstein, Devendra Desai, C. Ganesh Pai, Govind Makharia, Harsh Vardhan Tevethia, Joyce WY Mak, Kirandeep Kaur, Kiran Peddi, Mukesh Kumar Ranjan, Perttu Arkkila, Rakesh Kochhar, Rupa Banerjee, Saroj Kant Sinha, Siew Chien Ng, Stephen Hanauer, Suhang Verma, Usha Dutta, Vandana Midha, Varun Mehta, Vineet Ahuja, Ajit Sood   +25 more
doaj   +1 more source

Association Between Genetic Polymorphisms of Metabolic Enzymes and Azathioprine-Induced Myelosuppression in 1,419 Chinese Patients: A Retrospective Study

Frontiers in Pharmacology, 2021
The aim of this study was to investigate the correlation between genetic polymorphisms of azathioprine-metabolizing enzymes and adverse reactions of myelosuppression. To this end, a retrospective analysis was performed on 1,419 Chinese patients involving
Zhao-Yang Chen, Yang-Hui Zhu, Ling-Yan Zhou, Wei-Qiao Shi, Zhou Qin, Bin Wu, Yu Yan, Yu-Wen Pei, Ning-Ning Chao, Rui Zhang, Mi-Ye Wang, Ze-Hao Su, Xiao-Jun Lu, Zhi-Yao He, Zhi-Yao He, Ting Xu, Ting Xu   +16 more
doaj   +1 more source

Increased Risk of Liver Cirrhosis during Azathioprine Therapy for Crohn’s Disease

Case Reports in Gastrointestinal Medicine, 2020
Azathioprine is a cornerstone of the therapy of Crohn’s disease. Unfortunately, infections and malignancies are relatively common adverse effects related to this drug; however, cirrhosis is exceptionally reported as a side effect. We report the case of a
Jenny Roselli, Tommaso Innocenti, Erica Nicola Lynch, Laura Parisio, Giuseppe Macrì, Monica Milla, Tommaso Mello, Andrea Galli, Stefano Milani, Mirko Tarocchi   +9 more
doaj   +1 more source

Optical Coherence Tomography Reveals Longitudinal Changes in Retinal Damage Under Different Treatments for Neuromyelitis Optica Spectrum Disorder

Frontiers in Neurology, 2021
Background: Progressive retinal neuroaxonal damage after acute optic neuritis may occur in neuromyelitis optica spectrum disorder (NMOSD). However, it is unclear if treatments used to prevent attacks influence neurodegeneration.Objectives: We aimed to ...
Pei Zeng, Chen Du, Rui Zhang, Dongmei Jia, Feng Jiang, Moli Fan, Chao Zhang   +6 more
doaj   +1 more source

Immunoglobulin G4-Hepatopathy with Acute Hepatitis-Like Onset and Marked Centrilobular Necrosis: Clinicopathologically Unique Pattern of Hepatic Injury Related to Immunoglobulin G4-Related Disease

Case Reports in Gastroenterology, 2021
A 69-year-old man presented with jaundice and appetite loss. Blood analyses showed elevated aminotransferase levels, hyperbilirubinemia, positivity for antinuclear antibody, elevated immunoglobulin (Ig) G4 levels, and negativity for hepatitis virus ...
Kaori Mukai, Tsutomu Nishida, Shiro Adachi, Kengo Matsumoto, Naoto Osugi, Aya Sugimoto, Dai Nakamatsu, Masashi Yamamoto, Koji Fukui, Hiromi Tamura, Masami Inada   +10 more
doaj   +1 more source

Efficacy of 6-mercaptopurine treatment after azathioprine hypersensitivity in inflammatory bowel disease

, 2008
AIM:To investigate the efficacy of 6-mercaptopurine (6-MP) in cases of azathioprine (AZA) hypersensitivity in patients with inflammatory bowel disease. METHODS: Twenty nine previously confirmed Crohn’s disease (CD) (n = 14) and ulcerative colitis (UC)
Nagy, Ferenc, Lonovics, János, Farkas, Kaludia, Molnár, Tamás, Szepes, Zoltán, Nyári, Tibor András   +5 more
core   +1 more source

Intramolecular Charge Transfer in the Azathioprine Prodrug Quenches Intersystem Crossing to the Reactive Triplet State in 6-Mercaptopurine

, 2021
The thiopurine prodrugs 6-mercaptopurine and azathioprine are among the world’s essential medications for acute lymphoblastic leukemia, immunosuppression, and several autoimmune conditions.
Sean J., Hoehn, Luis A., Ortiz-Rodríguez, Glesmarie, Ortiz-Zayas, Marvin, Pollum, Steffen, Jockusch, Carlos, Crespo-Hernández   +5 more
core   +1 more source