Results 41 to 50 of about 88,642,428 (226)

The العلاقة بين التعدد الشكلي لجينة NUDT15 ذات الرقم ( rs116855232 ) والسمية النقوية المحرضة بمركبات البورين Mercaptopurine عند المرضى السوريين المشخص لديهم ابيضاض لمفاوي حاد

مجلة جامعة دمشق للعلوم الطبية, 2021
Background and Aims: NUDT15 genetic polymorphism is known to be associated with frequent hematopoietic toxicities during acute lymphoblastic leukemia (ALL) mercaptopurine therapy.
محمد ماجد محمد
doaj  

RESISTANCE TO 6-MERCAPTOPURINE: II THE SYNTHESIS OF THIOINOSINATE IN A 6-MERCAPTOPURINE-RESISTANT SUBLINE OF THE EHRLICH ASCITES CARCINOMA

, 1962
An assay for the synthesis of thioinosinate by the nucleotide pyrophosphorylase reaction in tissue extracts has been developed and has been applied in a comparison of the Ehrlich ascites carcinoma and a 6-mercaptopurine-resistant subline.
A. R. P. Paterson
core   +1 more source

Oral vancomycin solution is superior to capsule in inducing clinical biomarker and endoscopic remission in children with atypical ulcerative colitis

British Journal of Clinical Pharmacology, EarlyView.
Aims Atypical colitis (presenting reverse gradient colitis, backwash ileitis or rectal sparing) is associated with primary sclerosing cholangitis–ulcerative colitis (PSC). Oral vancomycin has been used to manage paediatric atypical colitis with/without confirmed PSC. Different preparations had shown different efficacy.
Laura Räisänen, Fariha Balouch, Claire Reilly, Christopher Burgess, Peter Lewindon   +4 more
wiley   +1 more source

Polymer-Based Nanoparticles as Drug Delivery Systems for Purines of Established Importance in Medicine

Nanomaterials, 2023
Many purine derivatives are active pharmaceutical ingredients of significant importance in the therapy of autoimmune diseases, cancers, and viral infections.
Piotr Szyk, Beata Czarczynska-Goslinska, Dariusz T. Mlynarczyk, Barbara Ślusarska, Tomasz Kocki, Marta Ziegler-Borowska, Tomasz Goslinski   +6 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Synthesis of 9-Aikyl-6-Mercaptopurine Analogues

, 1982
Department of chemotherapy Chittaranjan National Cancer Research Centre Calcntta-700 026 Manuscript received 13 November 1980, revised 18 November.
S. K. CHAKRABORTI, SADHANA BANERJEE, SUSHANTA DUTTA   +2 more
core   +1 more source

Thiopurine Enhanced ALL Maintenance (TEAM): study protocol for a randomized study to evaluate the improvement in disease-free survival by adding very low dose 6-thioguanine to 6-mercaptopurine/methotrexate-based maintenance therapy in pediatric and adult patients (0–45 years) with newly diagnosed B-cell precursor or T-cell acute lymphoblastic leukemia treated according to the intermediate risk-high group of the ALLTogether1 protocol

BMC Cancer, 2022
Background A critical challenge in current acute lymphoblastic leukemia (ALL) therapy is treatment intensification in order to reduce the relapse rate in the subset of patients at the highest risk of relapse.
Linea Natalie Toksvang, Bodil Als-Nielsen, Christopher Bacon, Ruta Bertasiute, Ximo Duarte, Gabriele Escherich, Elín Anna Helgadottir, Inga Rinvoll Johannsdottir, Ólafur G. Jónsson, Piotr Kozlowski, Cecilia Langenskjöld, Kristi Lepik, Riitta Niinimäki, Ulrik Malthe Overgaard, Mari Punab, Riikka Räty, Heidi Segers, Inge van der Sluis, Owen Patrick Smith, Marion Strullu, Goda Vaitkevičienė, Hilde Skuterud Wik, Mats Heyman, Kjeld Schmiegelow   +23 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

CRANIAL IRRADIATION AND CEREBROSPINAL-FLUID LEVELS OF 6-MERCAPTOPURINE IN CHILDREN WITH ACUTE LEUKEMIA

, 1991
We measured 6-mercaptopurine levels in the cerebrospinal fluid and plasma of 15 children undergoing treatment for acute leukemia. Plasma and cerebrospinal fluid samples obtained by lumbar puncture were collected before, during, and after cranial ...
Servidei, Tiziana, Riccardi, Riccardo, Riccardi, Anna Shirley, Riccardo Riccardi, Anna Riccardi, Tiziana Servidei, Rosa Laura Tartaglia, Anna Lasorella, Renato Mastrangelo   +8 more
core   +1 more source

A New Electrochemical Sensor for Direct Detection of Purine Antimetabolites and DNA Degradation

Journal of Analytical Methods in Chemistry, 2019
The development of a reliable electrochemical sensor using a hybrid nanocomposite consisting of ionic liquid (1-butyl-3-methylimidazolium hexafluorophosphate) functionalized graphene oxide (GrO-IL) and gold nanoparticles (AuNPs) stabilized by chitosan ...
Liliya K. Shpigun, Elena Yu. Andryukhina
doaj   +1 more source