Results 61 to 70 of about 88,642,428 (226)
THE FORMATION OF 6-MERCAPTOPURINE RIBOSIDE PHOSPHATE IN ASCITES TUMOR CELLS
, 1959 A nucleotide metabolite of 6-mercaptopurine has been isolated from Erhlich ascites carcinoma cells exposed to this compound under in vivo and in vitro conditions.
A. R. P. Paterson
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Sensing and Bio-Sensing Research, 2017 In this work the electrochemical behavior of 6-mercaptopurine (6-MP) on MWCNT-CTAB modified glassy carbon electrode (GCE) is reported in a phosphate buffer solution, pH 3.0. Cyclic voltammetric studies indicated that the oxidation process is irreversible
Jayant I. Gowda +2 more
doaj +1 more source
6-Mercaptopurine teratogenicity [PDF]
Postgraduate Medical Journal, 2002 We read with interest the review article on inflammatory bowel disease (IBD) in pregnancy.1 The author mentions that there has never been any demonstration of teratogenicity of 6-mercaptopurine (or azathioprine) in humans. We would like to report a case, which we encountered, of an infant with multiple congenital abnormalities whose mother received 6 ...
D H Tegay, R Tepper, J P Willner
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Journal of Pediatric Gastroenterology and Nutrition, EarlyView.Abstract Objectives To estimate the effect of attention deficit hyperactivity disorder (ADHD) and autism on the disease activity of inflammatory bowel disease (IBD) in pediatric and young patients. Methods Patients diagnosed with IBD between the ages of 6 and 24 years were identified in Danish nationwide registries 1996–2022.
Sabine Jansson +7 more
wiley +1 more source
, 1963 Nuclei prepared from cells of a 6-mercaptopurine-resistant subline of the Ehrlich ascites carcinoma differed from nuclei isolated from the parent line of cells in being markedly deficient in an enzymatic activity, 5′-nucleotidase.The nucleotidase ...
A. Hori, A. R. P. Paterson
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Canadian Journal of Gastroenterology, 2008 BACKGROUND: At least one-third of patients with inflammatory bowel disease do not respond or are intolerant to therapy with 6-mercaptopurine (6-MP). A subgroup fails to attain optimal levels of 6-thioguanine nucleotide (6-TGN) and instead shunts to 6 ...
Todd N Witte, Allen L Ginsberg
doaj +1 more source
Phytocorrection of Gastrointestinal Tract Structural Changes Caused by the Use of 6-Mercaptopurine
Антибиотики и Химиотерапия, 2020 It was shown that the course use of Ventrofit, a complex plant remedy, normalized the structural and functional integrity of the stomach and thin intestine mucous membranes damaged by the use of 6-mercaptopurine.
YA. G. Razuvaeva +4 more
doaj
Interaction of 6 mercaptopurine with calf thymus DNA--deciphering the binding mode and photoinduced DNA damage. [PDF]
PLoS ONE, 2014 DNA is one of the major intracellular targets for a wide range of anticancer and antibiotic drugs. Elucidating the binding between small molecules and DNA provides great help in understanding drug-DNA interactions and in designing of new and promising ...
Sayeed Ur Rehman +5 more
doaj +1 more source
JPGN Reports, EarlyView.Abstract Objectives Adalimumab biosimilars are as safe and effective compared to the originator. Adult patients with inflammatory bowel disease (IBD) who switched to a biosimilar have comparable outcomes, but pediatric data are limited. This study evaluates clinical outcomes of children and young adults with IBD following a nonmedical, insurance‐driven
Daniel Himelstein +5 more
wiley +1 more source
Improving the Solubility of 6‑Mercaptopurine via Cocrystals and Salts
, 2016 An antitumor drug, 6-mercaptopurine monohydrate, has a low oral bioavailability (about 16%) due to its poor aqueous solubility. To improve its solubility, two cocrystals of 6-mercaptopurine with 4-hydroxybenzoic acid (1) and 2,4-dihydroxybenzoic acid (2),
Tong-Bu Lu (1516030) +3 more
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