Results 61 to 70 of about 9,465,904 (238)
Differential toxic effects of azathioprine, 6-mercaptopurine and 6-thioguanine on human hepatocytes.
, 2008 International audienceThiopurines (azathioprine, 6-mercaptopurine and 6-thioguanine) are therapeutic compounds widely administered in the clinic for their multiple uses (autoimmune diseases, post-transplant immunosuppression and cancer).
Morel, Fabrice +5 more
core +1 more source
Arquivos de Gastroenterologia, 2012 CONTEXT: The use of thiopurine drugs such as azathioprine and 6-mercaptopurine has become quite common in the treatment of inflammatory bowel disease, transplantation and acute leukemias.
Gabriela Roncone Gastal +5 more
doaj +1 more source
Interaction of 6 mercaptopurine with calf thymus DNA--deciphering the binding mode and photoinduced DNA damage. [PDF]
PLoS ONE, 2014 DNA is one of the major intracellular targets for a wide range of anticancer and antibiotic drugs. Elucidating the binding between small molecules and DNA provides great help in understanding drug-DNA interactions and in designing of new and promising ...
Sayeed Ur Rehman +5 more
doaj +1 more source
6-Mercaptopurine teratogenicity [PDF]
Postgraduate Medical Journal, 2002 We read with interest the review article on inflammatory bowel disease (IBD) in pregnancy.1 The author mentions that there has never been any demonstration of teratogenicity of 6-mercaptopurine (or azathioprine) in humans. We would like to report a case, which we encountered, of an infant with multiple congenital abnormalities whose mother received 6 ...
D H Tegay, R Tepper, J P Willner
openaire +1 more source
JPGN Reports, EarlyView.Abstract Objectives Adalimumab biosimilars are as safe and effective compared to the originator. Adult patients with inflammatory bowel disease (IBD) who switched to a biosimilar have comparable outcomes, but pediatric data are limited. This study evaluates clinical outcomes of children and young adults with IBD following a nonmedical, insurance‐driven
Daniel Himelstein +5 more
wiley +1 more source
Indian Journal of Medical and Paediatric OncologyIntroduction 6-Mercaptopurine (6-MP) forms the backbone of maintenance chemotherapy for acute lymphoblastic leukemia (ALL). A Children's Oncology Group study found 3.9-fold increased risk of relapse in children with 6-MP adherence less than 90%
S. Abhilasha, Apoorva Bagalkotkar
doaj +1 more source
, 1983 An assay for 6-thioguanine (6-TG) nucleotide, a major metabolite of the cytotoxic drugs azathioprine, 6-mercaptopurine and 6-thioguanine in human red blood cells (RBCs) has been developed.
J L Maddocks, L Lennard
core +1 more source
Imaging of Abdominal Complications in Children With Acute Lymphoblastic Leukaemia
Journal of Medical Imaging and Radiation Oncology, EarlyView.ABSTRACT Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy and remains one of the most common causes of cancer‐related death in children and adolescents. Five‐year overall survival rates now exceed 90% with current multidrug chemotherapeutic regimens. This improvement, coupled with the toxicity of chemotherapy, has led to the
Luke R. Holmes +2 more
wiley +1 more source
Polarographic and voltammetric determination of 6-mercaptopurine and 6-thioguanine
, 1986 Conditions were found for the determination of 6-mercaptopurine (I) and 6-thioguanine (II) by TAST polarography, differential pulse polarography and fast-scan differential pulse voltammetry at a hanging mercury drop electrode.
Ludmila Dempírová +3 more
core +1 more source
, 2022 This project\u27s goal is to observe how the leukemia drug 6-mercaptopurine (6-MP) interacts with the ...
Hunt, Arabella
core +2 more sources