Results 81 to 90 of about 24,703 (234)
Does CytoSorb Interfere with Immunosuppression? A Pharmacokinetic and Functional Evaluation
PharmaceuticsBackground/Objectives: Cytokine release during organ transplantation contributes to primary graft dysfunction and requires careful immunomodulation. CytoSorb, a hemoadsorption device developed to reduce circulating cytokine levels, is increasingly used ...
Stephan Harm +4 more
doaj +1 more source
F1000Research, 2019 Fasting hypoglycemia is a known complication of mercaptopurine (6MP) maintenance therapy for acute lymphoblastic leukemia (ALL). It is associated with high levels of the methylated metabolite 6-methyl-mercaptopurine (6MMP).
Melissa Zhang, Bruce Bostrom
doaj +1 more source
A phase II clinical trial of 6-mercaptopurine (6MP) and methotrexate in patients with BRCA defective tumours: a study protocol [PDF]
, 2014 BACKGROUND: BRCA1 and BRCA2 genes are critical in homologous recombination DNA repair and have been implicated in familial breast and ovarian cancer tumorigenesis. Tumour cells with these mutations demonstrate increased sensitivity to cisplatin and poly (
+11 more
core +2 more sources
Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1382-1390, May 2026.Genetic variation has a significant impact on patients' response to medicines. Variations in important pharmacogenes have been evaluated in several studies and consequently led to international guidelines from clinical pharmacogenomics consortia. However, there are limited examples of these being implemented across the African continent despite the ...
Janine Scholefield +5 more
wiley +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2014 A reverse phase HPLC method is described for the determination of 6-mercaptopurine in bulk and tablets. Chromatography was carried on a C18 column using a mixture of acetonitrile and 0.05 mol/L sodium acetate buffer (10:90 v/v) as the mobile phase at a ...
Vanita Somasekhar
doaj +1 more source
Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients [PDF]
, 2016 Purpose: Methotrexate administration is associated with frequent adverse neurological events during treatment for childhood acute lymphoblastic leukemia.
Baird, Susan F. +5 more
core +2 more sources
Food Frontiers, Volume 7, Issue 3, May 2026.Rosa roxburghii‐derived exosome‐like nanovesicles target the intestine, repairing barriers, regulating gut microbiota, balancing Th17/Treg, and combating oxidative stress/inflammation to alleviate colitis, a promising UC therapy. ABSTRACT Plant‐derived nanovesicles (PDVs), an innovative and bioactive form of natural products, are key mediators of ...
Yuanyuan Wang +8 more
wiley +1 more source
Growth in Paediatric Inflammatory Bowel Disease
JCC Plus, Volume 1, Issue 3, May 2026.ABSTRACT Impaired linear growth is a common, clinically meaningful complication of paediatric inflammatory bowel disease (IBD), particularly Crohn's disease, arising from the combination of chronic intestinal inflammation, undernutrition, dysfunction of the growth hormone–insulin‐like growth factor‐1 axis, and iatrogenic effects such as glucocorticoid ...
Firas Rinawi +4 more
wiley +1 more source
BioImpacts, 2011 Introduction: 6-Mercaptopurine (6MP) is an important chemotherapeutic drug in the conventional treatment of childhood acute lymphoblastic leukemia (ALL).
Mohammad-Reza Rashidi +5 more
doaj +1 more source
Brazilian Journal of Medical and Biological Research, 2004 A procedure is described for the rapid determination of the intra-erythrocyte concentration of 6-mercaptopurine (6-MP) and its metabolites, 6-thioguanine nucleotides (6-TGN) and 6-methylmercaptopurine (6-MMP).
B.M. Oliveira +4 more
doaj +1 more source