Results 101 to 110 of about 88,642,428 (226)

Label-Free Surface-Enhanced Raman Scattering Imaging to Monitor the Metabolism of Antitumor Drug 6‑Mercaptopurine in Living Cells

, 2016
The molecular processes of drugs from cellular uptake to intracellular distribution as well as the intracellular interaction with the target molecule are critically important for the development of new antitumor drugs.
Shuhu Du (1472980), Renyong Liu (1712104), Jianping Wang (215292), Zhongping Zhang (1472983), Guangmei Han (1712101), Changlong Jiang (1712098), Bianhua Liu (1617766), Ming-Yong Han (1488601)   +7 more
core   +1 more source

Assay of 6-thioguanine nucleotide, a major metabolite of azathioprine, 6-mercaptopurine and 6-thioguanine, in human red blood cells

, 1983
An assay for 6-thioguanine (6-TG) nucleotide, a major metabolite of the cytotoxic drugs azathioprine, 6-mercaptopurine and 6-thioguanine in human red blood cells (RBCs) has been developed.
J L Maddocks, L Lennard
core   +1 more source

Effects of 6-mercaptopurine and its derivatives on human hepatocellular carcinoma and mammary adenocarcinoma cell lines [PDF]

Background and Objective: The 6-Mercaptopurine (6-MP) is used to treat autoimmune diseases and inflammation such as rheumatoid arthritis, Crohnʼs disease and ulcerative colitis. It is also very useful for acute leukemia in children.
Hakim, Muhammad Nazrul, Hong, Mak Jun, Ahmad, Zuraini, Keong, Yong Yoke   +3 more
core   +1 more source

Mixed Ligand Complexes of Some Bipositive Cations with 6-Mercaptopurine and Thioguanine in Solution

, 1980
Chemical Laboratories, University of Allahabad, Allahabad-211 002 Manuscript received 28 January 1976, revised 7 May 1979 accepted 9 July 1980 Mixed Ligand Complexes of Some Bipositive Cations with 6-Mercaptopurine and Thioguanine in ...
ARUN K. DEY, (Mrs.) RANJANA GHOSE, ANIMESH K. GHOSE   +2 more
core   +1 more source

Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response

Pharmacogenomics and Personalized Medicine, 2017
Rachid Abaji,1 Maja Krajinovic2 1Department of Pharmacology, 2Departments of Pediatrics and Pharmacology, CHU Sainte-Justine Research Center, University of Montreal, Montreal, QC, Canada Abstract: The thiopurine S-methyltransferase (TPMT) gene encodes ...
Abaji R, Krajinovic M
doaj  

Dexamethasone/vincristine pulses significantly reduce administered doses of 6MP/MTX during maintenance therapy in childhood acute lymphoblastic leukemia

EJC Paediatric Oncology
Background: Maintenance therapy with 6-Mercaptopurine (6MP) and Methotrexate (MTX) with or without dexamethasone (DEX) and vincristine (VCR) pulses, is crucial in childhood acute lymphoblastic leukaemia (ALL).
Valérie de Haas, Esmee Slot, Laura van den Berg, Rana Dandis, Hester de Groot-Kruseman, Rob Pieters   +5 more
doaj   +1 more source

Double Hydroxyl Salt as Smart Biocompatible pH-Responsive Carrier for 6-Mercaptopurine. [PDF]

Cancers (Basel), 2023
Sandomierski M, Jakubowski M, Ratajczak M, Patalas A, Gaweł-Bęben K, Lechwar P, Voelkel A.   +6 more
europepmc   +1 more source

The genetic toxicology of 6-mercaptopurine

Mutation Research/Reviews in Genetic Toxicology, 1993
Mosesso, Pasquale, Palitti, F.
openaire   +3 more sources

6-mercaptopurine Metabolites as Predictors of Neutropenia and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia [PDF]

Journal of Pediatrics Review
Background: 6-Mercaptopurine (6-MP) is used to treat childhood acute lymphoblastic leukemia (ALL). The concentrations of 6-MP metabolites in red blood cells (RBCs), specifically 6-thioguanine (6-TG) and 6-methyl mercaptopurine nucleotides (6-MMP), are ...
Ebrahim Salehifar, Omid Abed Khojasteh, Seyed Jalal Hosseinimehr, Hossein Karami, Mohammad Naderi Sorki, Hadi Darvish-Khezri, Kimia Karami   +6 more
doaj  

Immunomodulatory therapy in paediatric inflammatory bowel disease

Zdravniški Vestnik, 2013
Immunomodulatory drugs are indispensable in the treatment of children with both Crohn’s disease and ulcerative colitis, especially in maintaining remission.
András Arató
doaj