Results 101 to 110 of about 24,703 (234)

Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response

Pharmacogenomics and Personalized Medicine, 2017
Rachid Abaji,1 Maja Krajinovic2 1Department of Pharmacology, 2Departments of Pediatrics and Pharmacology, CHU Sainte-Justine Research Center, University of Montreal, Montreal, QC, Canada Abstract: The thiopurine S-methyltransferase (TPMT) gene encodes ...
Abaji R, Krajinovic M
doaj  

Azathioprine and 6-Mercaptopurine use in the Swiss IBD cohort : adverse effects, causes of discontinuation and risk of "flares" according to 6-TG levels [PDF]

, 2015
Background: To characterize and analyze in the Swiss IBD Cohort: a) reported Azathioprine (AZA) and 6-Mercaptopurine (6-MP) adverse effects (AE), b) causes of discontinuation and c) response to therapy according to gastroenterologists' clinical judgment,
Fournier, N., Lavrek, D., Mottet, C., Muller, D., Pittet, V.   +4 more
core  

6-mercaptopurine Metabolites as Predictors of Neutropenia and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia [PDF]

Journal of Pediatrics Review
Background: 6-Mercaptopurine (6-MP) is used to treat childhood acute lymphoblastic leukemia (ALL). The concentrations of 6-MP metabolites in red blood cells (RBCs), specifically 6-thioguanine (6-TG) and 6-methyl mercaptopurine nucleotides (6-MMP), are ...
Ebrahim Salehifar, Omid Abed Khojasteh, Seyed Jalal Hosseinimehr, Hossein Karami, Mohammad Naderi Sorki, Hadi Darvish-Khezri, Kimia Karami   +6 more
doaj  

Pharmacogenetics of 6-mercaptopurine in a black Zimbabwean cohort treated for acute lymphoblastic leukaemia. [PDF]

Pharmacogenomics, 2023
Chikondowa P, Munkombwe D, Chikwambi Z, Kuona P, Masimirembwa C.   +4 more
europepmc   +1 more source

Dexamethasone/vincristine pulses significantly reduce administered doses of 6MP/MTX during maintenance therapy in childhood acute lymphoblastic leukemia

EJC Paediatric Oncology
Background: Maintenance therapy with 6-Mercaptopurine (6MP) and Methotrexate (MTX) with or without dexamethasone (DEX) and vincristine (VCR) pulses, is crucial in childhood acute lymphoblastic leukaemia (ALL).
Valérie de Haas, Esmee Slot, Laura van den Berg, Rana Dandis, Hester de Groot-Kruseman, Rob Pieters   +5 more
doaj   +1 more source

Immunomodulatory therapy in paediatric inflammatory bowel disease

Zdravniški Vestnik, 2013
Immunomodulatory drugs are indispensable in the treatment of children with both Crohn’s disease and ulcerative colitis, especially in maintaining remission.
András Arató
doaj  

Tumor Microenvironment-Responsive 6-Mercaptopurine-Releasing Injectable Hydrogel for Colon Cancer Treatment. [PDF]

Gels, 2023
Kim S, Lee W, Park H, Kim K.
europepmc   +1 more source

Exploring the Enhanced Antiproliferative Activity of Turmeric Oil and 6-Mercaptopurine in a Combined Nano-Particulate System Formulation. [PDF]

Pharmaceutics, 2023
Ahmed TA, Ali EMM, Kalantan AA, Almehmady AM, El-Say KM.   +4 more
europepmc   +1 more source

Cephalothin as a Carrier of 6-Mercaptopurine for Targeting Cancer Tissues

Iraqi Journal of Pharmaceutical Sciences, 2017
A lower extracellular pH is one of the few well-documented physiological differences between tumour and normal tissues. On the other hand, elevated glutathione (GSH) level has been detected in many tumours compared with healthy surrounding tissues.
Mohammad H. Mohammad, Haider J.Al-Karagully   +1 more
doaj  

Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial. [PDF]

Clin Transl Gastroenterol, 2023
Swanson GR, Biglin M, Raff H, Chouhan V, Jochum S, Shaikh M, Francey L, Bishehsari F, Hogenesch J, Keshavarzian A.   +9 more
europepmc   +1 more source