Immunomodulatory therapy in paediatric inflammatory bowel disease
Zdravniški Vestnik, 2013 Immunomodulatory drugs are indispensable in the treatment of children with both Crohn’s disease and ulcerative colitis, especially in maintaining remission.
András Arató
doaj
The effect of 6-mercaptopurine and its derivatives on mammalian RNA-dependent RNA synthesis
, 1974 The effect of 6-mercaptopurine (6-MP) and its nucleoside and nucleotide derivatives on the rate of RNA synthesis with reticulocyte RNA-dependent RNA polymerase has been examined. Of the 6-MP derivatives tested only 6-mercaptopurine ribo-5′-monophosphate (
Downey, Kathleen M +3 more
core +1 more source
Tumor Microenvironment-Responsive 6-Mercaptopurine-Releasing Injectable Hydrogel for Colon Cancer Treatment. [PDF]
Gels, 2023 Kim S, Lee W, Park H, Kim K.
europepmc +1 more source
Cephalothin as a Carrier of 6-Mercaptopurine for Targeting Cancer Tissues
Iraqi Journal of Pharmaceutical Sciences, 2017 A lower extracellular pH is one of the few well-documented physiological differences between tumour and normal tissues. On the other hand, elevated glutathione (GSH) level has been detected in many tumours compared with healthy surrounding tissues.
Mohammad H. Mohammad +1 more
doaj
Impact of Chronotherapy on 6-Mercaptopurine Metabolites in Inflammatory Bowel Disease: A Pilot Crossover Trial. [PDF]
Clin Transl Gastroenterol, 2023 Swanson GR +9 more
europepmc +1 more source
Gold Nanoparticles Enhance the Anti-Leukemia Action of a 6-Mercaptopurine Chemotherapeutic Agent
, 2016 6-Mercaptopurine and its riboside derivatives are some of the most widely utilized anti-leukemic and anti-inflammatory drugs. Their short biological half-life and severe side effects limit their use.
Paul Podsiadlo (1990147) +5 more
core +1 more source
Exploring the Enhanced Antiproliferative Activity of Turmeric Oil and 6-Mercaptopurine in a Combined Nano-Particulate System Formulation. [PDF]
Pharmaceutics, 2023 Ahmed TA +4 more
europepmc +1 more source
The influence of NUDT15 variants on 6-mercaptopurine-induced neutropenia in Vietnamese pediatric acute lymphoblastic leukemia. [PDF]
HGG Adv, 2023 Nguyen ML +3 more
europepmc +1 more source
Early Initiation of Adalimumab Significantly Diminishes Postoperative Crohn's Disease Endoscopic Recurrence and Is Superior to 6-Mercaptopurine Therapy: An Open-Label, Randomized Controlled Study. [PDF]
J Clin Med, 2023 Hirsch A +13 more
europepmc +1 more source
Cellular Uptake and Transport Mechanism of 6-Mercaptopurine Nanomedicines for Enhanced Oral Bioavailability. [PDF]
Int J Nanomedicine, 2023 Zou Y +7 more
europepmc +1 more source