Results 91 to 100 of about 9,465,904 (238)
BioImpacts, 2011 Introduction: 6-Mercaptopurine (6MP) is an important chemotherapeutic drug in the conventional treatment of childhood acute lymphoblastic leukemia (ALL).
Mohammad-Reza Rashidi +5 more
doaj +1 more source
F1000Research, 2019 Fasting hypoglycemia is a known complication of mercaptopurine (6MP) maintenance therapy for acute lymphoblastic leukemia (ALL). It is associated with high levels of the methylated metabolite 6-methyl-mercaptopurine (6MMP).
Melissa Zhang, Bruce Bostrom
doaj +1 more source
Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1686-1701, October 2026.ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva +10 more
wiley +1 more source
The treatment of inflammatory bowel disease with 6‐mercaptopurine or azathioprine
, 2001 The thioguanine derivative, azathioprine, is a prodrug of 6-mercaptopurine that is further metabolized by various enzymes present in the liver and gut. Azathioprine and 6-mercaptopurine have been used in the treatment of inflammatory bowel disease, i.e ...
Nielsen, O. H. +5 more
core +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2014 A reverse phase HPLC method is described for the determination of 6-mercaptopurine in bulk and tablets. Chromatography was carried on a C18 column using a mixture of acetonitrile and 0.05 mol/L sodium acetate buffer (10:90 v/v) as the mobile phase at a ...
Vanita Somasekhar
doaj +1 more source
Exploring the Anticancer Potential of Schiff Base Complexes: A Mini‐Review
ChemMedChem, Volume 21, Issue 17, 14 September 2026.Schiff base metal complexes as promising anticancer agents: highlighting DNA interactions, cytotoxicity, molecular targets, and mechanisms of cancer cell death. Schiff bases are well known for their ability to form stable coordination compounds with several transition metals, making them valuable for medicinal chemistry purposes.
Atif Ahmad +4 more
wiley +1 more source
, 1963 Nuclei prepared from cells of a 6-mercaptopurine-resistant subline of the Ehrlich ascites carcinoma differed from nuclei isolated from the parent line of cells in being markedly deficient in an enzymatic activity, 5′-nucleotidase.The nucleotidase ...
A. Hori, A. R. P. Paterson
core +1 more source
Scientia Pharmaceutica, 2018 This research aimed to quantitatively bioanalyze 6-mercaptopurine (6-MP), 6-methylmercaptopurine (6-MMP), and 6-thioguanosine-5′-monophosphate (6-TGMP) in dried blood spots (DBS) prepared from a small volume of acute lymphoblastic leukemia (ALL ...
Supandi Supandi +3 more
doaj +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 9, September 2026.ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot +6 more
wiley +1 more source
Pancréatite aiguë médicamenteuse secondaire à la 6-mercaptopurine : à propos d’un cas [PDF]
, 2016 Introduction : Les patients porteurs de maladies inflammatoires chroniques de l’intestin semblent être à risque élevé de pancréatite aiguë ou chronique.
Samlani, Zohour +3 more
core +1 more source