Results 91 to 100 of about 88,642,428 (226)
, 2007 Xanthine oxidase-catalyzed hydroxylation reactions of the anticancer drug 6-mercaptopurine (6-MP) and its analog 2-mercaptopurine (2-MP) as well as 6-thioxanthine (6-TX) and 2-thioxanthine (2-TX) have been studied using UV-spectroscopy, high pressure ...
Thilagavathi, Ramasamy +4 more
core +1 more source
Preparation, Characterization and In Vitro Drug Release Studies of 6-mercaptopurine Thin Film [PDF]
, 2014 Oral thin films of 6-mercaptopurine were fabricated from mucoadhesive polymer, chitosan and polyvinylpyrrolidone for the purpose of prolonging drug release and improving its bioavailability.
Jagadeesh, S S +8 more
core +1 more source
BioImpacts, 2011 Introduction: 6-Mercaptopurine (6MP) is an important chemotherapeutic drug in the conventional treatment of childhood acute lymphoblastic leukemia (ALL).
Mohammad-Reza Rashidi +5 more
doaj +1 more source
Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins
ChemMedChem, Volume 21, Issue 19, 14 October 2026.Viral proteins represent key vulnerabilities in human coronaviruses (HCoVs). This review outlines inhibitors targeting spike (S), main protease (Mpro), papain‐like protease (PLpro), and RNA‐dependent RNA polymerase (RdRp), mapping chemically diverse strategies that disrupt entry and replication, and provides an integrated view of current candidates ...
Álvaro de la Cruz‐Potenciano +3 more
wiley +1 more source
Brazilian Journal of Pharmaceutical Sciences, 2014 A reverse phase HPLC method is described for the determination of 6-mercaptopurine in bulk and tablets. Chromatography was carried on a C18 column using a mixture of acetonitrile and 0.05 mol/L sodium acetate buffer (10:90 v/v) as the mobile phase at a ...
Vanita Somasekhar
doaj +1 more source
Control of Gemcitabine Activity With Blue and Red Light
Chemistry – A European Journal, Volume 32, Issue 38, 13 October 2026.Treating cancer with chemotherapy is generally associated with many side effects, which can be addressed by selectively releasing the desired drugs with visible light. Sixteen new blue light‐activatable cytostatics were introduced, with the gemcitabine derivative exhibiting ideal properties.
Nils F. Kersten +6 more
wiley +1 more source
Demonstration of enzymatic activity converting azathioprine to 6-mercaptopurine [PDF]
, 1978 The enzymatic conversion of azathioprine to 6-mercaptopurine was detected at pH 6.5 with rat liver supernatants, although the non-enzymatic reaction predominated at pH 7.0 and 7.5. Glutathione S-transferase may catalize this conversion. Activities of the
Hobara, Norio +2 more
core +1 more source
Scientia Pharmaceutica, 2018 This research aimed to quantitatively bioanalyze 6-mercaptopurine (6-MP), 6-methylmercaptopurine (6-MMP), and 6-thioguanosine-5′-monophosphate (6-TGMP) in dried blood spots (DBS) prepared from a small volume of acute lymphoblastic leukemia (ALL ...
Supandi Supandi +3 more
doaj +1 more source
Experimental Biology and Medicine, 1969 SummaryArabinosyl-6-mercaptopurine (Ara-6-MP), an effective inhibitor of the growth of the mouse tumors Ca755, Ehrlich and L1210, was incubated in fortified cellfree extracts of these tumor cells under conditions where 6-methylmercaptopurine riboside and inosine were converted to nucleotide. No nucleotide formation could be detected.
Le page, G A, Bell, J P, Wilson, M J
openaire +2 more sources
Genetic Polymorphism of Thiopurine S-Methyltransferase in Children with Acute Lymphoblastic Leukemia
Pakistan Journal of Medicine and DentistryBackground: 6-Mercaptopurine (6-MP), a widely used anti-metabolite for the maintenance phase of childhood acute lymphoblastic leukemia (ALL), has been observed to cause myelotoxicity due to genetic polymorphism of thiopurine methyl transferase (TPMT ...
Afrina Raza +3 more
doaj +1 more source