Results 71 to 80 of about 24,703 (234)
Frontiers in OncologyIntroductionPolymorphisms in NUDT15 may result in differences in mercaptopurine-induced toxicity. This study aimed to identify the frequency of the NUDT15 (c.415C>T; rs116855232) polymorphism and investigate the effect of this polymorphism on ...
Muhammad Muhammad +7 more
doaj +1 more source
Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes [PDF]
, 2014 Aim: We investigated candidate genes associated with thiopurine metabolism and clinical response in childhood acute lymphoblastic leukemia. Materials & methods: We performed genome-wide SNP association studies of 6-thioguanine and 6-mercaptopurine ...
Batzler, A. +10 more
core +1 more source
Severe acute axonal neuropathy following treatment with arsenic trioxide for acute promyelocytic leukemia: a case report [PDF]
, 2016 Peripheral neuropathy is a common complication of arsenic toxicity. Symptoms are usually mild and reversible following discontinuation of treatment. A more severe chronic sensorimotor polyneuropathy characterized by distal axonal-loss neuropathy can be ...
Kuhn, Marcus +3 more
core +3 more sources
Hemagglutination Induced by Aabinosyl-6-Mercaptopurine.
Experimental Biology and Medicine, 1966 SummaryArabinosyl-6-mercaptopurine, a nucleoside that prolonged the survival of skin homografts, induced non-specific agglutination of either sheep or human red blood cells. The drug was bound to red blood cell stroma and the number of sites occupied on the stroma was determined as approximately 1.2 × 105 per red blool cell for tanned sheep cells and 6.
, Kimball, S J, Herriot, G A, LePage
openaire +2 more sources
Direct evidence of singlet molecular oxygen [O2 (1Δg)] production from UVA excited 6‐thioguanine
Photochemistry and Photobiology, EarlyView.6‐Thioguanine (6‐TGua) is incorporated into DNA as a purine analogue, inhibiting cell replication. Patients treated with 6‐TGua are more prone to developing skin cancer due to the photoexcitation of 6‐TGua by UVA radiation (as illustrated in the Jablonski diagram). Upon exposure to UVA, the excited 6‐TGua generates 1O2.
André L. Lopes +6 more
wiley +1 more source
Medicina UniversitariaAcute lymphoblastic leukemia (ALL) is the most prevalent form of cancer in children, and maintenance therapy with 6-mercaptopurine (6-MP) is crucial for treating these patients.
Ana L. Valdez-Arellanes +2 more
doaj +1 more source
Indonesian Journal of Chemistry, 2018 6-Mercaptopurine is a chemotherapeutic agent of the antimetabolite class. This study aims to analyze simultaneous validation of 6-mercaptopurine (6-MP), 6-methylmercaptopurine (6-MMP), and 6-thioguanosine-5’-monophosphate (6-TGMP) in dried blood spot ...
Supandi Supandi +3 more
doaj +1 more source
Escherichia coli EHEC Germany outbreak preliminary functional annotation using BG7 system [PDF]
, 2011 We have annotated the European outbreak E. coli EHEC genome sequenced by BGI (6-2-2011) and assembled with MIRA by Nick Loman (6-2-2011 ). Our system BG7, Bacterial Genome annotation of Era7 Bioinformatics, predicts ORFs and annotates them based on ...
Eduardo Pareja +4 more
core +2 more sources
Spondyloarthritis Associated With Collagenous Colitis—Case Report and Literature Review
Clinical Case Reports, Volume 14, Issue 5, May 2026.ABSTRACT Collagenous colitis (CC) is a subtype of microscopic colitis characterized by chronic watery diarrhea with normal endoscopic findings. Although often linked to autoimmune diseases, its association with spondyloarthropathy (SpA) is rare and poorly documented.
Charlotte Bouvy +4 more
wiley +1 more source
Clinical Pharmacology &Therapeutics, Volume 119, Issue 5, Page 1371-1381, May 2026.The World Health Organization Model Essential Medicines List and African national essential medicines lists (EMLs) detail drugs intended to be consistently available within national health systems, thereby supporting clinicians and pharmacists in making evidence‐based treatment decisions.
Tinashe A. Mazhindu +5 more
wiley +1 more source