Results 1 to 10 of about 7,935 (218)

Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era? [PDF]

Frontiers in Medicine, 2021
Thiopurines have been a cornerstone in the treatment of inflammatory bowel disease (IBD). Although they have been used for more than 50 years, there are still some unsolved issues about their efficacy and, also, some safety concerns, mainly the risk of ...
Viviana Laredo, Fernando Gomollón
exaly   +9 more sources

Clinical Functional Assignment of TPMT and NUDT15 Alleles by the Clinical Pharmacogenetics Implementation Consortium Pharmacogene Curation Expert Panel. [PDF]

Clin Pharmacol Ther
The Clinical Pharmacogenetics Implementation Consortium (CPIC) TPMT/NUDT15 Pharmacogene Curation Expert Panel (PCEP) conducted a comprehensive review of clinical, laboratory, and computational evidence to determine the clinical function assignments for TPMT and NUDT15 star alleles.
Tibben BM, Maillard M, Pratt VM, Moyer AM, Figueroa DM, Whirl-Carrillo M, Gaedigk A, Stocco G, Schwab M, Caudle KE, Yang JJ.   +10 more
europepmc   +2 more sources

Systematic review and network meta-analysis comparing the efficacy of conventional therapy and biologics to prevent endoscopic postoperative recurrence in patients with Crohn’s disease [PDF]

Therapeutic Advances in Gastroenterology
Background: As no direct comparison is available between drugs to prevent endoscopic postoperative recurrence (POR) in Crohn’s disease (CD), hierarchizing these therapeutic options remains challenging. Objectives: We aimed to compare the effectiveness of
Marianne Hupé, Bruno Pereira, Anthony Buisson   +2 more
doaj   +2 more sources

Tricyclic Analogs of Thioguanine as Photosensitizers of Reactive Oxygen Species-Induced DNA and RNA Damage [PDF]

Biomolecules
Analogs of tricyclic thiopurine nucleosides combine structural features of endogenous DNA adducts with efficient photosensitizing chromophores, making them valuable models for studying nucleic acid damage induced by reactive oxygen species (ROS). In this
Katarzyna Taras-Goslinska, Katarzyna Krancewicz, Bronislaw Marciniak   +2 more
doaj   +2 more sources

Cytotoxicity of Thiopurine Drugs in Patients with Inflammatory Bowel Disease

Toxics, 2022
The effectiveness of thiopurine drugs in inflammatory bowel disease (IBD) was confirmed more than a half-century ago. It was proven that these can be essential immunomodulatory medications.
Oliwia Zakerska-Banaszak, Liliana Łykowska-Szuber, Michał Walczak, Joanna Żuraszek, Aleksandra Zielińska, Marzena Skrzypczak-Zielińska   +5 more
doaj   +1 more source

Pharmacogenomic tests in Oncology - finding the right dose

Brazilian Journal of Oncology, 2021
A pharmacogenetics/genomics (PGx) anticancer drug testing program is being developed by Kurtz and his group at the Brazilian National Cancer Institute (INCA).
Jeziel Basso, Gilberto Schwartsmann
doaj   +1 more source

Pregnancy outcome in women with inflammatory bowel disease treated with anti-tumor necrosis factor and/or thiopurine therapy: a multicenter study from Japan [PDF]

Intestinal Research, 2016
Background/AimsAnti-tumor necrosis factor drugs (anti-TNF) and thiopurines are important treatment options in patients with inflammatory bowel disease (IBD), including during pregnancy.
Shunsuke Komoto, Satoshi Motoya, Yuji Nishiwaki, Toshiyuki Matsui, Reiko Kunisaki, Katsuyoshi Matsuoka, Naoki Yoshimura, Takashi Kagaya, Makoto Naganuma, Nobuyuki Hida, Mamoru Watanabe, Toshifumi Hibi, Yasuo Suzuki, Soichiro Miura, Ryota Hokari,   +15 more
doaj   +1 more source

Plasma lipidomic profiling of thiopurine-induced leukopenia after NUDT15 genotype-guided dosing in Chinese IBD patients

Frontiers in Nutrition, 2023
IntroductionThiopurines, azathiopurine (AZA) and mercaptopurine (6-MP) have been regularly used in the treatment of inflammatory bowel disease (IBD). Despite optimized dosage adjustment based on the NUDT15 genotypes, some patients still discontinue or ...
Pan Li, Kang Chao, Kang Chao, Zhanhua Hu, Lulu Qin, Ting Yang, Jing Mao, Xia Zhu, Xia Zhu, Xia Zhu, Pinjin Hu, Pinjin Hu, Xueding Wang, Xiang Gao, Xiang Gao, Min Huang   +15 more
doaj   +1 more source

Pharmacotherapy of inflammatory bowel diseases: efficacy performance and safety management

Терапевтический архив, 2021
Treatment of inflammatory bowel diseases IBD (Crohns disease, ulcerative colitis) is aimed at achieving clinical, endoscopic and histological remission, minimizing surgical complications, and ensuring a normal quality of life.
Igor G. Bakulin, Maria I. Skalinskaya, Igor V. Maev, Ekaterina V. Skazyvaeva, Mariia S. Zhuravleva, Larisa B. Gaikovaya, Natalia V. Bakulina, Aleksei I. Ermakov, Ekaterina S. Alekseenko, Kristina N. Ivanova, Mikhail V. Solovev   +10 more
doaj   +1 more source

Risk of malignancies in patients with inflammatory bowel disease who used thiopurines as compared with other indications: a territory-wide study

Therapeutic Advances in Gastroenterology, 2020
Aims: Thiopurines are believed to increase cancer risks, but data from Asian patients are sparse. We determined the risks of malignancies in thiopurine users with inflammatory bowel disease (IBD) or other indications from Hong Kong. Methods: All patients
Kelvin Y. C. Zheng, Chuan-Guo Guo, Irene O. L. Wong, Lijia Chen, Ho Yin Chung, Ka Shing Cheung, Wai K. Leung   +6 more
doaj   +1 more source