Results 41 to 50 of about 7,935 (218)

Characterisation of autophagy induction by the thiopurine drugs azathioprine, mercaptopurine and thioguanine in THP-1 macrophages [PDF]

Activating autophagy may be therapeutically beneficial, and we have previously shown that azathioprine (AZA), an immunomodulatory drug, induces autophagy.
Barlow, Peter, Masson, Connan D., Masson, Connan, Barlow, Peter G., Fraser, Jenny; id_orcid, Stevens, Craig, Findlay-Greene, Fern, Sousa, Filipa Henderson, Henderson, Paul, Fraser, Jennifer A, Henderson Sousa, Filipa   +10 more
core   +1 more source

Therapeutic role of methotrexate in pediatric Crohn’s disease

Biomolecules & Biomedicine, 2018
The main role of therapy in Crohn’s disease (CD) is to achieve long-term clinical remission, and to allow for normal growth and development of children.
Zlatko Djurić, Ljiljana Šaranac, Ivana Budić, Voja Pavlović, Jelena Djordjević   +4 more
doaj   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases

Frontiers in Pharmacology, 2021
Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) of unknown etiology, characterized by repeated relapse and remission. The efficacy of thiopurine in IBD was first reported in the late 1960s.
Keiichi Tominaga, Takeshi Sugaya, Takanao Tanaka, Mimari Kanazawa, Makoto Iijima, Atsushi Irisawa   +5 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

How I treat my inflammatory bowel disease-patients with thiopurines?

, 2016
Thiopurines are essential drugs to maintain remission in patients with inflammatory bowel disease (IBD). Thiopurines used in IBD are azathioprine (2.0-2.5 mg/kg), mercaptopurine (1.0-1.5 mg/kg) and thioguanine (0.2-0.3 mg/kg).
Meijer, Berrie, Mulder, Chris Jj, de Boer, Nanne K H, van Bodegraven, Adriaan A   +3 more
core   +1 more source

PACSIN2 regulates mercaptopurine cytotoxicity and cellular biomechanics through Rac1 modulation in intestinal epithelial cells

Frontiers in Pharmacology
IntroductionMercaptopurine (MP) is used to treat pediatric acute lymphoblastic leukemia and inflammatory bowel disease (IBD). The Protein Kinase C and Casein Kinase Substrate in Neurons 2 (PACSIN2) rs2413739 polymorphism is an expression-quantitative ...
Alessia Norbedo, Giulia Zudeh, Donatella Fiducioso, Beatrice Senigagliesi, Pietro Parisse, Loredana Casalis, Giuliana Decorti, Marianna Lucafò, Gabriele Stocco, Gabriele Stocco   +9 more
doaj   +1 more source

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

British Journal of Clinical Pharmacology, EarlyView.
Aims Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, comparable markers of hepatic drug‐metabolizing capacity are not routinely ...
Louise Westberg Strejby Christensen, Anne Kirstine Boas, Emilie Clausen, Nicoline Elers Koch, Anne Byriel Walls, Lotte Stig Nørgaard, Michael Asger Andersen, Anissa Aharaz, Rikke Lundsgaard Nielsen, Olivia Bornæs, Juliette Tavenier, Baker Nawfal Jawad, Helle Gybel Juul‐Larsen, Esben Iversen, Ove Andersen, Lona Louring Christrup, Kim Peder Dalhoff, Morten Baltzer Houlind   +17 more
wiley   +1 more source

Are we using and monitoring thiopurines and biologics optimally?

, 2014
The use of biologics and thiopurines in patients with inflammatory bowel disease has increased rapidly over the last 2 decades with both classes of drugs being used more frequently and earlier in the disease course.
Irving, Peter M.; id_orcid
core   +1 more source

Characterisation of autophagy modulation by thiopurines in inflammatory bowel disease [PDF]

Background Inflammatory bowel disease (IBD), which includes Crohn’s disease (CD) and ulcerative colitis, are chronic diseases of the gastrointestinal tract. Genetic studies have identified strong association between genes involved in autophagy, ER-stress/
Masson, Connan Dayton
core   +1 more source