Results 51 to 60 of about 7,935 (218)

How to diagnose and treat patients with inflammatory bowel disease [PDF]

Arhiv za farmaciju, 2017
Inflammatory bowel diseases (IBD) are idiopathic, chronic intestinal inflammatory diseases. IBD pathogenesis is related to altered immune response and its complex interaction with gut microbiota, genetic and environmental factors.
Sokić-Milutinović Aleksandra
doaj   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, EarlyView.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Excess risk of urinary tract cancers in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study

, 2016
IF 6.32International audienceBackgroundThe risk of urinary tract cancers, including kidney and bladder cancers, was increased in transplant recipients receiving thiopurines.AimTo assess the risk of urinary tract cancers in patients with inflammatory ...
Novacek, Gottfried, Coulibaly, Baya, Allez, Mathieu, Beaugerie, L., Seksik, Philippe, Bourrier, A., Bouvier, A., Brillaut, Gaëlle, Reinisch, Walter, Bossa, Fabrizio, Colombel, F., Cosnes, J., Michetti, Pierre, Katsanos, Konstantinos, Filippi, Jérôme, Carbonnel, Franck, Colombel, Jean Frédéric, Laharie, David, Brixi, Hedia, Fumery, Mathurin, Deplanque, Dominique, Abitbol, Vered, Bourreille, Arnaud, Détré, Patricia, Louis, Edouard, Färkkilä, Martti, Danese, Silvio, Moreau, Jacques, Marteau, P., Dewit, Olivier, Demolin, Julie, Roblin, Xavier, Bouhnik, Yoram, Sarter, Hélène, Nachury, Maria, Simon, T., Carrat, F., Peyrin-Biroulet, Laurent, Bommelaer, Gilles, Malamut, Georgia   +39 more
core   +1 more source

Thiopurines related malignancies in inflammatory bowel disease: Local experience in Granada, Spain.

, 2013
Journal Article;AIM To investigate the incidence of neoplasms in inflammatory bowel disease (IBD) patients and the potential causative role of thiopurines. METHODS We performed an observational descriptive study comparing the incidence of malignancies
Redondo-Cerezo, Eduardo, Gómez-García, María, Sánchez-Capilla, Antonio Damián, Teresa-Galván, Javier De, Cabello-Tapia, Maria José   +4 more
core   +1 more source

Análisis de la determinación de niveles de tiopurínicos en pacientes pediátricos con enfermedad inflamatoria intestinal

Anales de Pediatría, 2020
Resumen: Introducción y objetivos: Las tiopurinas son fármacos muy empleados para el mantenimiento de la remisión en pacientes con enfermedad inflamatoria intestinal. Se conocen cuáles son los niveles plasmáticos óptimos, y existe controversia acerca de
Rafael Martín-Masot, María Pilar Ortiz Pérez, Natalia Ramos Rueda, Juliana Serrano Nieto, Javier Blasco-Alonso, Víctor Manuel Navas-López   +5 more
doaj   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

The effects of aminosalicylates or thiopurines on the risk of colorectal cancer in inflammatory bowel disease

, 2017
International audienceBACKGROUND:Whether aminosalicylates or thiopurines reduce the risk of colorectal cancer (CRC) in inflammatory bowel (IBD) disease is controversial.AIM:To assess simultaneously the chemopreventive effect of aminosalicylates or ...
Seksik, P., Beaugerie, L., Colombel, J.-F., Carrat, F., Peyrin-Biroulet, L.   +4 more
core   +1 more source

Real-World Experience with AGA Guidelines in the Management of Crohn’s Disease following Ileocolonic Resection: A Retrospective Cohort Study

Gastroenterology Research and Practice, 2020
Background. Postoperative endoscopic recurrence (PER) is common in patients with Crohn’s disease (CD) after surgery. The impact of the American Gastroenterological Association (AGA) guideline adherence on PER in real life remains unclear. Methods.
Shasha Tang, Wei Liu, Weilin Qi, Tunan Yu, Qian Cao, Xiaolong Ge, Wei Zhou   +6 more
doaj   +1 more source

Inflammatory Bowel Disease Is Associated With an Increased Risk of End‐Stage Renal Disease: A Population‐Based Cohort Study

Alimentary Pharmacology &Therapeutics, EarlyView.
In a retrospective population‐based cohort study using the University of Manitoba IBD Epidemiology Database, persons with IBD have an increased risk of ESRD by nearly 50%, with CD showing greater risk than UC. Bowel surgery, allopurinol use and oral steroid therapy are important predictors, emphasising the necessity of careful renal monitoring in IBD ...
Onuma Sattayalertyanyong, Zoann Nugent, Bryce Barr, Keevin N. Bernstein, Charles N. Bernstein   +4 more
wiley   +1 more source

Personalization of thiopurine therapy: Current recommendations and future perspectives

Acta Pharmaceutica
Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel disease ...
Urbančič Dunja, Pasha Flaka, Šmid Alenka, Mlinarič-Raščan Irena   +3 more
doaj   +1 more source