Results 61 to 70 of about 7,935 (218)
Gastroenterology Research and Practice, 2018 Background and Aims. Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited.
Daniela Pugliese +8 more
doaj +1 more source
PLoS ONE, 2016 BackgroundThiopurines are known to cause lymphopenia (
Marius Vögelin +9 more
doaj +1 more source
Therapeutic Advances in Gastroenterology, 2020 The therapeutic management of patients with severe steroid-refractory ulcerative colitis still represents a critical clinical challenge. In this setting, cyclosporin is an effective and rapidly acting induction treatment that is applied in combination ...
Ingo Ganzleben +10 more
doaj +1 more source
Internal Medicine Journal, EarlyView.Abstract Background Pharmacogenomic‐guided medication management optimises drug therapy to enhance patient outcomes. Despite clinical utility, implementation in Australia remains limited, partly due to the lack of clear and consistent guidance. Aim This study evaluated the presence and consistency of pharmacogenomic testing indication categories and ...
Ruby Soueid +4 more
wiley +1 more source
Inflammatory Bowel Diseases, 2018 Thiopurine metabolite monitoring to proactively dose optimize to achieve therapeutic levels has not been used consistently, and it is unclear if this would lead to better outcomes. We aimed to compare 6-month outcomes between standard and optimized dosing strategies and define long-term predictors of thiopurine durability.Two hundred sixteen pediatric ...
Elizabeth, Spencer +3 more
openaire +2 more sources
The use of thiopurines for the treatment of inflammatory bowel disesases in clinical practice
, 2008 Background: Thiopurines are the most commonly used immunomodulatory drugs in inflammatory bowel diseases. Aim: To evaluate the use, the therapeutic and safety profiles of thiopurines in a large sample of IBD patients.
G. Casella +15 more
core +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 10, October 2026.ABSTRACT Background Neurotoxicity is a rare, often dose‐limiting adverse effect of methotrexate (MTX) therapy that disproportionally affects Latino children. Factors contributing to the observed disparity are not well understood. This study leveraged admixture mapping to identify genetic regions associated with MTX‐related neurotoxicity susceptibility ...
Rachel D. Harris +24 more
wiley +1 more source
Thiopurine Metabolism in the Era of Combotherapy [PDF]
Inflammatory Bowel Diseases, 2016 6-thioguanine nucleotides levels are associated with clinical remission in patients with inflammatory bowel disease (IBD) on thiopurine monotherapy. Recently, few studies investigated the interaction between thiopurine metabolism and anti-tumor necrosis factor therapy among patients with IBD on combotherapy.
Roblin, Xavier +2 more
openaire +3 more sources
Postoperative Effects of Thiopurines in Patients with Intestinal Behçet's Disease
, 2015 BACKGROUND: No studies have heretofore specifically focused on the efficacy of postoperative thiopurine therapy in intestinal Behçet's disease (BD). We conducted this study to assess the clinical effects of postoperative thiopurines in patients with ...
이현정 +6 more
core +1 more source