Clinical Pharmacogenetics Implementation Consortium Guidelines for Thiopurine Methyltransferase Genotype and Thiopurine Dosing [PDF]
Clinical Pharmacology & Therapeutics, 2011 Thiopurine methyltransferase (TPMT) activity exhibits monogenic co-dominant inheritance, with ethnic differences in the frequency of occurrence of variant alleles. With conventional thiopurine doses, homozygous TPMT-deficient patients (~1 in 178 to 1 in 3,736 individuals with two nonfunctional TPMT alleles) experience severe myelosuppression, 30-60% of
Relling, M V +9 more
openaire +3 more sources
Azathioprine-Induced Peripheral T Cell Apoptosis And Drug Response In Patients With Crohn’s Disease [PDF]
, 2011 Background and Aim: the long time interval for a trial of thioupurine therapy and the potential side effects in spite of the proven efficacy, do not encourage their use as early therapeutic option in Crohn’s Disease (CD).
Cossu, Andrea
core
Thiopurines: Recent Topics and Their Role in the Treatment of Inflammatory Bowel Diseases
Frontiers in Pharmacology, 2021 Ulcerative colitis (UC) and Crohn's disease (CD) are chronic inflammatory bowel diseases (IBD) of unknown etiology, characterized by repeated relapse and remission. The efficacy of thiopurine in IBD was first reported in the late 1960s.
Keiichi Tominaga +5 more
doaj +1 more source
Multi-site investigation of strategies for the clinical implementation of CYP2D6 genotyping to guide drug prescribing [PDF]
, 2019 PURPOSE: A number of institutions have clinically implemented CYP2D6 genotyping to guide drug prescribing. We compared implementation strategies of early adopters of CYP2D6 testing, barriers faced by both early adopters and institutions in the process
Beitelshees, Amber L. +26 more
core +1 more source
Therapeutic role of methotrexate in pediatric Crohn’s disease
Biomolecules & Biomedicine, 2018 The main role of therapy in Crohn’s disease (CD) is to achieve long-term clinical remission, and to allow for normal growth and development of children.
Zlatko Djurić +4 more
doaj +1 more source
Liver dysfunction in patients with IBD under immunosuppressive treatment: do we need to fear? [PDF]
, 2010 International ...
Beaugerie, Laurent, Gerbes, Alexander L.
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Consensus definitions of 14 severe acute toxic effects for childhood lymphoblastic leukaemia treatment: a Delphi consensus [PDF]
, 2016 Although there are high survival rates for children with acute lymphoblastic leukaemia, their outcome is often counterbalanced by the burden of toxic effects.
Attarbaschi, Andishe +20 more
core +2 more sources
How to diagnose and treat patients with inflammatory bowel disease [PDF]
Arhiv za farmaciju, 2017 Inflammatory bowel diseases (IBD) are idiopathic, chronic intestinal inflammatory diseases. IBD pathogenesis is related to altered immune response and its complex interaction with gut microbiota, genetic and environmental factors.
Sokić-Milutinović Aleksandra
doaj +1 more source
Anales de Pediatría, 2020 Resumen: Introducción y objetivos: Las tiopurinas son fármacos muy empleados para el mantenimiento de la remisión en pacientes con enfermedad inflamatoria intestinal. Se conocen cuáles son los niveles plasmáticos óptimos, y existe controversia acerca de
Rafael Martín-Masot +5 more
doaj +1 more source
TCD4pos lymphocytosis in rheumatoid and psoriatic arthritis patients following TNFα blocking agents [PDF]
, 2017 BACKGROUND: Lymphocyte expansion and true lymphocytosis are commonly observed in the everyday clinical practice. The meaning of such phenomenon is often poorly understood so that discrimination between benign and malignant lymphocytosis remains ...
Amodeo, Rachele +11 more
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