Results 71 to 80 of about 7,935 (218)

Impact of thiopurines and tumour necrosis factor antagonists on primary sclerosing cholangitis outcomes in patients with inflammatory bowel disease

, 2022
International audienceBackground: Patients with primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) are at risk of biliary tract cancer and liver damage (possibly leading to liver transplantation), and are often treated for IBD with
Beaugerie, Laurent, Olivier Chazouillères, Biron, Amélie, Amélie Biron, Julien Kirchgesner, Chazouillères, Olivier, Kirchgesner, Julien, Laurent Beaugerie   +7 more
core   +1 more source

What Happens to Patients with Inflammatory Bowel Disease Who Are Intolerant to Thiopurines?

Inflammatory Intestinal Diseases
Introduction: The clinical consequences for patients with inflammatory bowel disease (IBD) who stop treatment owing to side effects have not been fully investigated.
Helena Gensmyr-Singer, Pontus Karling
doaj   +1 more source

Operationalizing Precision Medicine in Drug Development: Predictive Biomarkers, Companion Diagnostics, and Regulatory Pathways

Clinical Pharmacology &Therapeutics, Volume 120, Issue 4, Page 914-929, October 2026.
Precision medicine offers the opportunity to improve the benefit–risk profile of new therapies by prospectively identifying patients most likely to respond or least likely to experience harm; however, its systematic integration into drug development remains inconsistent outside oncology.
Ingrid Holst‐Laubjerg, José M.A. Moreira   +1 more
wiley   +1 more source

Thiopurines in Inflammatory Bowel Diseases : New perspectives to optimise safety and efficacy [PDF]

, 2015
Patients with Crohn's disease and ulcerative colitis are frequently prescribed thiopurines as a maintenance treatment (azathioprine and 6-mercaptopurine).
Wong, D.R.
core   +5 more sources

Acute thiopurine overdose: analysis of reports to a National Poison Centre 1995-2013.

PLoS ONE, 2014
Literature regarding acute human toxicity of thiopurines is limited to a handful of case reports. Our objectives were to describe all cases of overdose with thiopurines reported to the Swiss Toxicological Information Centre between 1995-2013.
Claudia Gregoriano, Alessandro Ceschi, Christine Rauber-Lüthy, Hugo Kupferschmidt, Nicholas R Banner, Stephan Krähenbühl, Anne B Taegtmeyer   +6 more
doaj   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, Volume 16, Issue 9, Page 1825-1839, September 2026.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Impaired Long-Term Quantitative Cellular Response to SARS-CoV-2 Vaccine in Thiopurine-Treated IBD Patients

Cells
Background: Studies investigating the long-term cellular immune response to SARS-CoV-2 mRNA vaccines in patients with inflammatory bowel disease (IBD) remain limited, particularly among those receiving immunosuppressive therapy. Methods: We prospectively
Luis Mayorga Ayala, Claudia Herrera-deGuise, Juliana Esperalba, Xavier Martinez-Gomez, Elena Céspedes Martinez, Xavier Serra Ruiz, Virginia Robles, Ernesto Lastiri, Zahira Perez, Elena Oller, Candela Fernandez-Naval, Mónica Martinez-Gallo, Francesc Casellas, Natalia Borruel   +13 more
doaj   +1 more source

Single‐Incision Laparoscopy‐First Strategy in Crohn's Disease: Risk Factors for Conversion and Surgical Outcomes

Annals of Gastroenterological Surgery, Volume 10, Issue 5, Page 1602-1611, September 2026.
In this retrospective study of 289 patients with Crohn's disease undergoing a single‐incision laparoscopy‐first (SILS‐first) strategy, conversion to open surgery was required in only 11.8% of cases. Fistula formation, colon resection, and smoking history were identified as independent risk factors for conversion, while postoperative complications and ...
Yuki Horio, Motoi Uchino, Yusuke Tomoo, Kentaro Nagano, Kurando Kusunoki, Ryuichi Kuwahara, Kei Kimura, Kozo Kataoka, Masataka Ikeda, Hiroki Ikeuchi   +9 more
wiley   +1 more source

Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose

Oncotarget, 2017
Thiopurines are widely used as anticancer and immunosuppressive agents. However, life-threatening myelotoxicity has been noticed and largely explained by genetic variations, including NUDT15 polymorphisms (e.g., rs116855232). In this study, we conduct a meta-analysis to investigate the impact of rs116855232 on thiopurines-induced myelotoxicity ...
Yin, Dandan, Xia, Xuyang, Zhang, Junlong, Zhang, Shouyue, Liao, Fei, Zhang, Ge, Zhang, Yan, Hou, Qianqian, Yang, Xue, Wang, Hong, Ma, Zhigui, Wang, Heyao, Zhu, Yiping, Zhang, Wei, Wang, Yuelan, Liu, Bo, Wang, Lanlan, Xu, Heng, Shu, Yang   +18 more
openaire   +3 more sources

Population Pharmacokinetics and Dose De‐Escalation Regimens of Subcutaneous Vedolizumab in Inflammatory Bowel Disease

JCC Plus, Volume 1, Issue 5, September 2026.
ABSTRACT Background Vedolizumab is a therapeutic antibody approved for the treatment of Crohn's disease and ulcerative colitis. The population pharmacokinetics (popPK) of intravenous (IV) administered vedolizumab have been described, but remain to be defined for subcutaneous (SC) administration.
S. I. Anjie, N. Vreman, K. B. Gecse, M. Löwenberg, G. R. D'Haens, R. A. A. Mathôt   +5 more
wiley   +1 more source