Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2019 Introduction Ras‐related C3 botulinum toxin substrate 1 (Rac1), a member of the Rho‐GTPase family of proteins, could be an Alzheimer's disease (AD) triggering co‐factor due to its effect on both amyloid precursor protein (APP) and tau.
S.Scott Sutton +3 more
doaj +1 more source
JGH Open, Volume 10, Issue 4, April 2026.ABSTRACT Crohn's disease (CD) is a chronic inflammatory condition of the bowel with a rising global incidence. Its complex etiology involves genetic susceptibility, environmental factors, and alterations in the gut microbiota, leading to dysregulated immune responses.
Yoon‐Kyo An +3 more
wiley +1 more source
Acetarsol Suppositories: Effective Treatment for Refractory Proctitis in a Cohort of Patients with Inflammatory Bowel Disease. [PDF]
, 2018 BACKGROUND: Management of proctitis refractory to conventional therapies presents a common clinical problem. The use of acetarsol suppositories, which are derived from organic arsenic, was first described in 1965.
Bhattacharyya, Joya +5 more
core +1 more source
Real-Life Anti-Tumour Necrosis Factor Experience in > 500 Paediatric United Kingdom Inflammatory Bowel Disease Patients. [PDF]
, 2017 OBJECTIVES: To measure the effectiveness, safety and use of anti-Tumour necrosis Factor (TNF) therapy in paediatric inflammatory bowel disease (PIBD) in the United Kingdom (UK).
Akobeng, A +23 more
core +1 more source
Systematic review: macrophage activation syndrome in inflammatory bowel disease [PDF]
, 2013 BACKGROUND: Recently, there have been increasingly frequent reports on the occurrence of macrophage activation syndrome (MAS) in patients with inflammatory bowel disease (IBD).
CASCIO, ANTONIO, COTTONE, Mario, Fries W
core +1 more source
Impact of NUDT15 polymorphisms on thiopurines-induced myelotoxicity and thiopurines tolerance dose
Oncotarget, 2017 Thiopurines are widely used as anticancer and immunosuppressive agents. However, life-threatening myelotoxicity has been noticed and largely explained by genetic variations, including NUDT15 polymorphisms (e.g., rs116855232). In this study, we conduct a meta-analysis to investigate the impact of rs116855232 on thiopurines-induced myelotoxicity ...
Yin, Dandan +18 more
openaire +3 more sources
Frontiers in OncologyAcute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, with relapse being a major obstacle to successful treatment. Our understanding of the mechanisms driving chemotherapy resistance and ultimately relapse in leukemia remains ...
Xiaohong Wang +13 more
doaj +1 more source
Pharmacological studies on uptake, metabolism, and resistance to anti-cancer drugs : insights into the treatment of leukemia [PDF]
, 2013 Leukemia is blood cancer that begins in the bone marrow and characterized by abnormal production of white blood cells. Due to advances in treatment, there has been a dramatic increase in survival rate for patients with different types of leukemia.
Karim, Hazhar
core +1 more source
Immunosuppressants in modern approaches to treatment of inflammatory bowel diseases
Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2013 Aim of investigation. To characterize frequency of TPMT gene mutations in patients with inflammatory bowel diseases (IBD) with myelosuppression and to estimate value of these mutations in prognosis of myelosuppression development in patients receiving ...
O. B. Schukina +6 more
doaj
Prédicteurs de première lésion néoplasique colique chez les patients surveillés par coloscopies itératives pour maladie inflammatoire chronique intestinale [PDF]
, 2015 Introduction: Little is known about risk factors of first colorectal neoplasia (CRN) in inflammatory bowel diseases (IBD) patients after a surveillance colonoscopy without dysplasia.
Kirchgesner, Julien
core +1 more source