Results 101 to 110 of about 7,935 (218)

Thiopurines in the Management of Crohn’s Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study

Canadian Journal of Gastroenterology and Hepatology, 2016
Background and Aims. Thiopurines are used in the treatment of Crohn’s disease (CD) and thiopurine S-methyltransferase (TPMT) activity can guide thiopurine dosing to avoid adverse events.
Amine Benmassaoud, Xuanqian Xie, Motaz AlYafi, Yves Theoret, Alain Bitton, Waqqas Afif, Talat Bessissow   +6 more
doaj   +1 more source

Impaired transport as a mechanism of resistance to thiopurines in human T-lymphoblastic leukemia cells

, 2006
In order to better understand the mechanisms of resistance to thiopurines, we studied two sublines of the MOLT4 T-lymphoblastic leukemia cell line, resistant to 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG).
Peterson, Curt,, Fotoohi, Alan Kambiz,, Lindqvist Appell, Malin,, Albertioni, Freidoun,   +3 more
core   +1 more source

Optimisation de la réponse aux thiopurines par la pharmacogénétique : approches in vitro et cliniques [PDF]

, 2014
Thiopurines are cytotoxic and immunosuppressive drugs widely prescribed, mainly in inflammatory bowel disease (IBD). They constitute one of the best success story of pharmacogenetic implementation into clinical practice based on the screening of ...
Chouchana, Laurent
core  

Different profile of efficacy of thiopurines in ulcerative colitis and Crohn's disease

, 2015
Background: Thiopurines are effective drugs in treating ulcerative colitis (UC) and Crohn's disease (CD) even if studies that specifically investigate these drugs' profile of efficacy in UC compared with CD are scarce.
Musto, Dario, Diaferia, Maria, Castiglione, Fabiana, Rispo, Antonio, De Palma, Giovanni Domenico, Maione, Francesco, Caporaso, Nicola, Testa, Anna, Donetto, Sara, Nardone, Olga   +9 more
core   +1 more source

TPMT genotype and the use of thiopurines in pediatric inflammatory bowel disease.

, 2005
Background Thiopurines are used in the treatment of inflammatory bowel disease. They are metabolised via methylation by thiopurine-S-methyltransferase (TPMT), which displays a genetically determined polymorphic activity.
VENTURA, ALESSANDRO, GIRALDI, TULLIO, BARTOLI, FIORA, FONTANA M., STOCCO, GABRIELE, BARABINO A., LIONETTI P., DECORTI, GIULIANA, FEZZI M., MALUSA' N., MARTELOSSI S.   +10 more
core  

Managing Ulcerative Colitis – The Guidelines and Beyond [PDF]

European Medical Journal Gastroenterology, 2013
Management guidelines offer clinicians clear, evidence-based and often succinct treatment advice. For ulcerative colitis these guidelines describe the use of 5-ASA, corticosteroids, thiopurines, cyclosporine, and anti-TNFα therapies.
Mitchell RKL Lie, C Janneke van der Woude   +1 more
doaj  

Impact of thiopurines on the natural history and surgical outcome of ulcerative colitis: a cohort study

, 2018
ObjectiveThiopurines are used as maintenance therapy in ulcerative colitis (UC), but whether these drugs influence the natural history of the disease is unknown.
Yang Cao, Jonas Halfvarson, Scott Montgomery, Carl Eriksson, Sara Rundquist   +4 more
core   +1 more source

Thiopurines in inflammatory bowel disease: pharmacogenetics, therapeutic drug monitoring and clinical recommendations

, 2005
There is a growing interest in the use of thiopurines (azathioprine, 6-mercaptopurine and 6-thioguanine) for the management of inflammatory bowel disease. The genetically controlled thiopurine (S)-methyltransferase enzyme is involved in the metabolism of
Derijks, L. J.J., Drs Al Hadithy, Asmar Faris Yassin, Brouwers, J.R.B.J., de Boer, N. K.H., Escher, J.C., Mulder, CJJ, Al Hadithy, Asmar, Brouwers, JRBJ, Derijks, L.J.J., Escher, Hankje, Escher, J. C., de Boer, NKH, de Boer, N.K.H., Mulder, C.J.J., Al Hadithy, A. F.Y., Mulder, C. J.J., Brouwers, J. R.B.J., Derijks, LJJ   +17 more
core   +1 more source

Pharmacogenetic studies of thiopurines [Elektronisk resurs] : focus on thiopurine methyltransferase

, 2005
Pharmacogenetics represents the study ofvariability in drug response due to genetic variations. The thiopurines (6-mercaptopurine, 6-thioguanine and azathioprine) are prodrugs which require metabolic transformation to exert effect.
Lindqvist Appell, Malin,, Eichelbaum, Michel,   +1 more
core  

Thiopurine S-methyltransferase – An important intersection of drug-drug interactions in thiopurine treatment

Biomedicine & Pharmacotherapy
Understanding the molecular mechanisms of medicines is crucial for developing novel drugs, for repurposing existing medicines, and for predicting toxicities. Thiopurine S-methyltransferase (TPMT) serves as an exemplary case in personalized medicine, as its activity is influenced by genetic variants, co-factors, substrates, and inhibitors, which lead to
Dunja Urbančič, Marko Jukič, Alenka Šmid, Stanislav Gobec, Janez Jazbec, Irena Mlinarič-Raščan   +5 more
openaire   +3 more sources