Results 101 to 110 of about 10,789 (224)

6-methylmercaptopurine-induced leukocytopenia during thiopurine therapy in inflammatory bowel disease patients [PDF]

, 2017
Background and Aim: Thiopurines have a favorable benefit–risk ratio in the treatment of inflammatory bowel disease. A feared adverse event of thiopurine therapy is myelotoxicity, mostly occurring due to toxic concentrations of the pharmacologically ...
Bodegraven, A.A. (Ad) van, Boer, K.H.N. (Nanne) de, Bouma, G. (Gerd), Derijks, L.J.J., Kreijne, J.E. (Joany), Meijer, B. (Berrie), Mulder, C.J.J. (Chris), van Moorsel, S.A.W. (Sofia A W), Wong, D.R. (Dennis R), Woude, C.J. (Janneke) van der   +9 more
core   +3 more sources

Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach

Mediators of Inflammation, 2015
Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model
Misbah Misdaq, Sonia Ziegler, Nicolas von Ahsen, Michael Oellerich, Abdul R. Asif   +4 more
doaj   +1 more source

The drug-survival of low-dose thioguanine in patients with inflammatory bowel disease: a retrospective observational study

Therapeutic Advances in Gastroenterology
Background: Thiopurines are commonly used to treat inflammatory bowel disease but withdrawal due to side effects are common. Thioguanine has been suggested to be better tolerated than conventional thiopurines.
Helena Gensmyr-Singer, Mårten Werner, Pontus Karling   +2 more
doaj   +1 more source

Histological remission of autoimmune hepatitis after the addition of allopurinol and azathioprine dose reduction

Autopsy and Case Reports, 2017
The standard therapy for some autoimmune diseases consists of a combination of corticosteroids and thiopurines. In non-responders to thiopurine drugs, the measurement of the metabolites of azathioprine, 6-thioguanine, and 6-methylmercaptopurine, can be a
Ana Luiza Vilar Guedes, Adriana Ribas Andrade, Vinicius Santos Nunes, Fabiana Roberto Lima, Evandro Sobroza de Mello, Suzane Kioko Ono, Débora Raquel Benedita Terrabuio, Eduardo Luiz Rachid Cançado   +7 more
doaj   +1 more source

Thiopurines inhibit bovine viral diarrhea virus production in a thiopurine methyltransferase-dependent manner

Journal of General Virology, 2008
The family Flaviviridae comprises positive-strand RNA viral pathogens of humans and livestock with few treatment options. We have previously shown that azathioprine (AZA) has in vitro activity against bovine viral diarrhea virus (BVDV). While the mechanism of inhibition is unknown, AZA and related thiopurine nucleoside analogues have been used as ...
Spencer, Hoover, Rob, Striker
openaire   +2 more sources

Switching from reference infliximab to CT-P13 in patients with inflammatory bowel disease: 12 months results [PDF]

, 2017
Background: Biological agents, such as infliximab, have transformed the outcomes of patients with immune-mediated inflammatory diseases. The advent of biosimilar treatment options such as CT-P13 promises to improve the availability of biological therapy,
Argüelles Arias, Federico, Castro Laria, Luisa, Guerra Veloz, María Fernanda, Maldonado Pérez, Belén, Merino Bohórquez, Vicente, Perea Amarillo, Raúl, Romero Gómez, Manuel, Vilches Arenas, Ángel   +7 more
core  

Thiopurines in the Management of Crohn’s Disease: Safety and Efficacy Profile in Patients with Normal TPMT Activity—A Retrospective Study

Canadian Journal of Gastroenterology and Hepatology, 2016
Background and Aims. Thiopurines are used in the treatment of Crohn’s disease (CD) and thiopurine S-methyltransferase (TPMT) activity can guide thiopurine dosing to avoid adverse events.
Amine Benmassaoud, Xuanqian Xie, Motaz AlYafi, Yves Theoret, Alain Bitton, Waqqas Afif, Talat Bessissow   +6 more
doaj   +1 more source

Liver transplantation [PDF]

, 2014
Purpose of review: Long-term survival of liver transplant recipients is threatened by increased rates of de-novo malignancy and recurrence of hepatocellular carcinoma (HCC), both events tightly related to immunosuppression.
Burroughs, AK, De la Mata, M, Rodríguez-Perálvarez, M   +2 more
core  

Managing Ulcerative Colitis – The Guidelines and Beyond [PDF]

European Medical Journal Gastroenterology, 2013
Management guidelines offer clinicians clear, evidence-based and often succinct treatment advice. For ulcerative colitis these guidelines describe the use of 5-ASA, corticosteroids, thiopurines, cyclosporine, and anti-TNFα therapies.
Mitchell RKL Lie, C Janneke van der Woude   +1 more
doaj  

Prevalence of past or current Hepatitis B infection and factors for non-vaccination in Chinese patients with inflammatory bowel diseases [PDF]

, 2013
The Conference program's website is located at http://jsibd.jp/1staocc/program.htmlPoster Oral: PO-46Information on the prevalence and natural history of chronic hepatitis B (HBV) among Asian IBD patients are scarce.
Chan, KH, Hung, IFN, Leung, WK, Liu, KSH, Seto, WKW, Tong, TSM   +5 more
core